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  • 1
    Electronic Resource
    Electronic Resource
    Replication intermediates formed during initiation of DNA synthesis in methotrexate-resistant CHOC 400 cells are enriched for sequences derived from a specific, amplified restriction fragment (1986)
    s.l. : American Chemical Society
    Biochemistry 25 (1986), S. 441-449 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00350a025
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  • 2
    Electronic Resource
    Electronic Resource
    Excess volumes of binary 1-alkanol/nonane mixtures at temperatures between 293.15 and 333.15 K (1986)
    s.l. : American Chemical Society
    Journal of chemical & engineering data 31 (1986), S. 483-487 
    Details
    ISSN: 1520-5134
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/je00046a029
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  • 3
    Electronic Resource
    Electronic Resource
    Excess volumes of binary 1-alkanol/hexane mixtures at temperatures between 283.15 and 323.15 K (1986)
    s.l. : American Chemical Society
    Journal of chemical & engineering data 31 (1986), S. 487-492 
    Details
    ISSN: 1520-5134
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/je00046a030
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  • 4
    Electronic Resource
    Electronic Resource
    Expression pattern of the bullous pemphigoid-180 antigen in normal and neoplastic epithelia (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: BP180 is a 180kDa hemidesmosomal protein recognized by bullous pemphigoid (BP) and pemphigoid gestationis (PG) autoantibodies. Recent cloning and sequence analysis performed by our laboratory have revealed that BP180 is a transmembrane protein with a long extracellular collagen-like region. A rabbit polyclonal antibody has been generated against a recombinant protein, designated GST-NΔ1. containing a segment of the BP180 ectodomain. The resulting antiserum. RNΔ1 A, was shown to specifically react with BP180 on immunoblot, and labelled the extracellular region of the epidermal hemidesmosome on immunoelectron microscopy. A panel of normal and neoplastic human tissues were analysed by indirect immunofluorescence (IF) and RNΔ1A, to determine the distribution of BP180. A total of nine basal cell carcinomas (BCCs) and four squamous cell carcinomas (SCCs) of the skin were also studied. Intense IF staining was seen along the basement membrane zone (BMZ) of the epidermis, hair follicles, and the periphery of sebaceous gland lobules. The sebaceous lobules showed more intense staining in areas close to the duct, The epithelial BMZ of the following tissues also reacted with RNΔ1A: cornea, ocular conjunctiva, buccal mucosa. upper oesophagus, placenta (amnion placentum). umbilical cord and transitional epithelium of the bladder, The epithelium of the jejunum and ovary tailed to react with RNΔ1A, Staining of the BCCs and SCCs was variable. Five of six nodular BCCs showed some anti-BP180 staining at the tumour-stromal interface, although the level of staining was less intense than that observed in the overlying normal epidermis. All three morphoeic BCCs analysed in this investigation did not show any staining with RNΔ1A. Three of four SCCs showed weak staining at the tumour-stromal interface. Thus, the tissue distribution of BP180 paralleled that of hemidesmosomes, and expression of this protein was found to be decreased or absent in cutaneous neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02665.x
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  • 5
    Electronic Resource
    Electronic Resource
    Mechanisms of Neural Patterning and Specification in the Development Cerebellum (1995)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 18 (1995), S. 385-408 
    Details
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ne.18.030195.002125
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  • 6
    Electronic Resource
    Electronic Resource
    Deprotonation of bis(dimethylphosphino)ethane ligand of a cationic chromium alkyl (1989)
    s.l. : American Chemical Society
    Organometallics 8 (1989), S. 2071-2073 
    Details
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/om00110a043
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  • 7
    Electronic Resource
    Electronic Resource
    Selective metal-catalyzed autoxidation of 2-arylpropionaldehydes. An improved synthesis of ibuprofen (1987)
    s.l. : American Chemical Society
    The @journal of organic chemistry 52 (1987), S. 287-290 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00378a027
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  • 8
    Electronic Resource
    Electronic Resource
    An education programme promoting organ donation for 13–14 year old schoolchildren (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 1 (1995), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: Many programmes have attempted community education in organ donation. Too often these ‘preach to the converted’ or concentrate on special interest groups, thus failing to widely influence community perceptions of transplantation and organ donation.As 13–14 year old children appear sufficiently mature to be receptive to challenging ideas yet may not yet have developed fixed biases or opinions to impair concept assimilation, an educational package dealing with dialysis/transplantation and organ donation was tested in two evenly aged, socio-economic and sex matched student groups at this age level in a single co-educational school. One group only was exposed to a 3 h comprehensive course in renal structure and function, dialysis and transplantation. the two groups were assessed 1 year later by questionnaire to test the retention of information and, more importantly, to compare attitudes to organ donation.Statistically significant differences characterized the knowledge of and attitudes towards dialysis and transplantation between the two groups. In particular, the tutored group was much more likely to agree to organ donation by self (P〈0.009) or by relatives (P〈0.03) when compared to the untutored group.This study demonstrates that a short, simple education course for 13–14 year old students can favourably change their perceptions and attitudes towards organ donation. the wider application of similar courses may have a positive impact upon dialysis and transplantation awareness and, ultimately, on national donor rates, becoming a useful addition to national strategies to increase organ donation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.1995.tb00022.x
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  • 9
    Electronic Resource
    Electronic Resource
    Euthanasia: a personal experience in gynecologic oncology (1995)
    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 5 (1995), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Euthanasia means the active causation of death by a life-shortening medical act performed on a seriously ill patient who has a concrete expectation to die. The request for euthanasia has always existed. In medical ethics the value of the protection of human life and the value of respect for the desire to die in dignity are both standards of equal order. In the process of euthanasia the wish of the patient is the most important. It is the responsibility of the doctor in attendance to keep all the personnel involved very well informed about the wishes of the patient, to prevent difficulties in the process of decision making. One has to realize that the emotional burden assumed by the doctor and nurses is very important. They become involved in the process of taking leave but have to give priority to their task as caregivers. Euthanasia can take place only as a part of terminal care which is given with much effort and personal concern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1995.05010071.x
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  • 10
    Electronic Resource
    Electronic Resource
    Pargyline reduces/prevents neuroleptic-induced acute dystonia in monkeys (1987)
    Springer
    Psychopharmacology 93 (1987), S. 207-213 
    Details
    ISSN: 1432-2072
    Keywords: Extrapyramidal syndromes ; Dystonia ; Neuroleptics ; Pargyline ; Monoamine oxidase ; Primates ; Cebus albifrons monkeys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The neuropharmacologic mechanisms underlying neuroleptic-induced extrapyramidal syndromes (EPS) were studied using a nonhuman primate model. Twenty-six Cebus albifrons monkeys were given weekly challenges of haloperidol (0.025 mg/kg IM), and half of the animals received the monoamine oxidase (MAO) inhibitor pargyline (5 mg/kg PO) daily for 17 consecutive days during the protocol. Pargyline caused no changes in baseline behaviors, but significantly reduced haloperidol-induced acute dystonia (AD) (-67%, P〈0.002) and parkinsonism (-56%, P〈0.005). The majority (8 of 13) of the experimental group had complete prevention of neuroleptic-induced EPS during cotreatment with pargyline. Behavioral scores returned to baseline levels after stopping pargyline, and did not show the further sensitization to haloperidol-induced AD that occurred in the control group. The possible mechanisms by which an MAO inhibitor might influence neuroleptic-induced AD were considered. The most likely explanation would appear to involve facilitation of striatal dopamine (DA) neurotransmission by inhibition of intra- and extraneuronal MAO, thus supporting the hypothesis that AD is due to decreased striatal DA function with secondary cholinergic hyperfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179935
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