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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Stochastic environmental research and risk assessment 1 (1987), S. 37-52 
    ISSN: 1436-3259
    Keywords: Cyclonic precipitation ; mathematical modeling ; simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract A stochastic description is developed for extratropical cyclonic precipitation fields at synoptic and meso scales as they are typically observed by radars over the Earth. This description attempts to account I) for the synoptic scale behavior of a cyclonic storm (its birth, its synoptic scale motion trajectory, and its dissipation) II) for the synoptic-scale organizational structure of subsynoptic precipitation areas (rainbands, precipitation cores and raincells) within a cyclonic storm; and III) for the behavior of subsynoptic precipitation areas, in terms of their births, their spatial configuration evolutions, their motions, and their deaths (dissipation). The precipitation cores and the raincells are taken as the building blocks of the subsynoptic precipitation, areas within a cyclonic rainfield.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Stochastic environmental research and risk assessment 2 (1988), S. 263-279 
    ISSN: 1436-3259
    Keywords: Cyclonic rain fields ; cyclone center behavior ; stochastic model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract Earlier the authors have developed a stochastic geometric model for extratropical cyclonic precipitation fields at synoptic and meso scales as they are typically observed by weather radars over the mainland U S A (see Kavvas and Puri 1983; Kavvas et al. 1987). Here the earlier mathematical development of the model is further extended by incorporating the stochastic description of cyclone center births and their evolutions over U S A into the model.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Stochastic environmental research and risk assessment 2 (1988), S. 281-294 
    ISSN: 1436-3259
    Keywords: precipitation field ; stochastic time-space evolution ; simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract The time-space evolution of an extratropical cyclonic precipitation field over U S A is simulated in a stochastic setting as outlined in Kavvas et al. (1988). The birth of a cyclonic storm is characterized by the simultaneous birth of a cyclone center and births of subsynoptic precipitation areas (SPA) at preferred locations around the cyclone center. The precipitation cores and cells which are used as the fundamental building blocks of the SPAs are approximated by circular precipitation areas (CPA) of different sizes. The time space evolution of the precipitation field after the birth is governed by (1) the movement of the synoptic cyclone described by the cyclone center trajectory, (2) independent nonidentically distributed random velocities of the individual CPAs relative to the cyclone center, (3) the births of new CPAs in time and space relative to the cyclone center, (4) the independent evolution in time of the individual spatially uniform intensities of the existing CPAs, (5) the expansion and shrinkage of the existing CPAs in the course of movement and (6) the dissipation (death) of a random number of existing CPAs within the cyclonic system. The computer simulation, the results of which are presented in this paper, successfully reproduced the general mesoscale and synoptic scale features of the radar detected cyclonic rain fields as observed by Austin and Houze (1972), Houze et al. (1976), Hobbs (1978), Hobbs and Locatelli (1978), Houze (1981), Houze and Hobbs (1982) and others.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Astrophysics and space science 135 (1987), S. 219-228 
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Unsteady free-convection flows near an infinite vertical plate in a rotating medium in the presence of a constant transverse magnetic field are investigated under an arbitrary time-dependent heating of the plate. By using the Laplace transform technique, the Green's function of the problem is determined and exact solutions are obtained for special cases of the time-dependent heating effect. The thermal influence on skin friction at the plate and the displacement thickness of the boundary layer are determined, and the structure of the thermal wave trains is discussed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für angewandte Mathematik und Physik 39 (1988), S. 150-156 
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract An algorithm for finding inverse Laplace transforms of exponential form for two classes of functions is established and used to derive a set of new formulas which are presented as a table of Laplace transform pairs. These formulas are useful in problems in fluid mechanics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 12 (1996), S. 19-23 
    ISSN: 1437-9813
    Keywords: Key words Hirschsprung’s disease ; Endothelin-B receptor gene ; Endothelin-3 gene ; Mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The endothelin-B receptor gene (EDNRB) and the endothelin-3 gene (EDN3) have recently been recognized as susceptibility genes for Hirschsprung’s disease (HD). Novel EDNRB mutations have been detected in non-syndromic HD patients with heterozygous forms, and homozygous mutations of the EDNRB or the EDN3 genes have been reported in HD patients associated with type 2 Waardenburg syndrome. These observations confirm that impaired function of the endothelin-B receptor or endothelin-3 is involved in the aetiology of some human HD cases. EDNRB mutations appear to be associated with short-segment HD, in contrast to RET mutations, which are found mainly in long-segment aganglionosis.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1437-9813
    Keywords: Congenital diaphragmatic hernia ; Newborn ; Pulmonary hypertension ; Calcitonin gene-related peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A congenital diaphragmatic hernia (CDH) model was induced in pregnant rats following administration of 100 mg nitrofen. The fetuses were stored and fixed in Bouin's solution for 24 h after caesarean section at term. After fixation, the lungs were dissected out. Immunostaining of the CDH lungs and controls with rabbit anti-rat calcitonin gene-related peptide (CGRP) antibody at “optimal” and “supraoptimal” dilution levels was obtained by examining the intensity of staining with a series of dilutions of the antisera from 1: 1,000 to 1: 20,000. Supraoptimal dilution detects variations in antigen concentration that may be masked if the routine optimal dilution is used. Immunostaining of the lung by antisera to platelet-derived growth factor (PDGF) and alpha-smooth-muscle actin (ASMA) was performed to examine vascular remodelling. The number of CGRP-immunoreactive cells was significantly (P 〈0.001) greater in the lungs of CDH rats (n = 26) (0.74 +-0.19 NEB [neuroepithelial bodies]/mm2; mean +- SEM) compared with controls (n = 21) (0.30+-0.16 NEB/mm2) seen at supraoptimal dilution (1:20,000). Since CGRP is a vasodilator, this could have important implications in the development of pulmonary hypertension. The pattern of ASMA and PDGF immunostaining was similar in CDH lungs and controls, and therefore, vascular remodelling is not a feature of CDH lungs in fetuses delivered by caesarean section and not exposed to hypoxia.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 12 (1996), S. 19-23 
    ISSN: 1437-9813
    Keywords: Hirschsprung's disease ; Endothelin-B receptor gene ; Endothelin-3 gene ; Mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The endothelin-B receptor gene (EDNRB) and the endothelin-3 gene (EDN3) have recently been recognized as susceptibility genes for Hirschsprung's disease (HD). Novel EDNRB mutations have been detected in non-syndrommc HD patients with heterozygous forms, and homozygous mutations of the EDNRB or the EDN3 genes have been reported in HD patients associated with type 2 Waardenburg syndrome. These observations confirm that impaired function of the endothelin-B receptor or endothelin-3 is involved in the aetiology of some human HD cases. EDNRB mutations appear to be associated with shortsegment HD, in contrast to RET mutations, which are found mainly in long-segment aganglionosis.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 12 (1996), S. 11-18 
    ISSN: 1437-9813
    Keywords: Key words RET ; RET proto-oncogene ; Hirschsprung’s disease ; Multiple endocrine neoplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  RET gene alterations as disease-causative mutations have been demonstrated in five different disease entities: Hirschsprung’s disease (HD); papillary thyroid carcinoma; and three types of inherited cancer syndromes: multiple endocrine neoplasia (MEN) 2A, MEN 2B, and familial medullary thyroid carcinoma. RET is expressed during embryogenesis in a temporally and spatially regulated manner, and plays an important role in the normal development of a variety of cell lineages, particularly in the establishment of the enteric nervous system. RET mutations observed in patients with HD are scattered along the gene without any hot spots, and possess a loss-of-function effect. RET mutations are detected with a higher incidence among familial cases (50%) than sporadic cases (15% – 20%), and are more closely associated with long-segment HD than short-segment disease. In contrast to HD mutations, missense mutations observed in MEN 2 syndromes occur at specific codons, and gene rearrangements are characteristic in papillary thyroid carcinoma. Both missense mutations and gene rearrangements act in a dominant fashion, and cause constitutive phosphorylation on the tyrosine of RET and highly enhance RET kinase activity, leading to transforming or oncogenic activity.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 12 (1997), S. 576-579 
    ISSN: 1437-9813
    Keywords: Infantile hypertrophic pyloric stenosis ; Neuronal nitric oxide synthase ; messenger RNA ; Reverse transcription-polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nitric oxide (NO) has been described as a mediator of smooth muscle relaxation in the mammalian gastrointestinal tract. The enzyme neuronal nitric oxide synthase (NOS) catalyzes the formation of NO. We examined the expression of the neuronal NOS gene at the messenger RNA (mRNA) level in pyloric smooth-muscle biopsy specimens from six patients with infantile hypertrophic pyloric stenosis (IHPS) using a reverse transcription-polymerase chain reaction (RT-PCR) technique. For controls, smooth-muscle layer specimens of pylorus (n = 3), ileum (n = 2), and colon (n = 2) were used. With 31 cycles of PCR reaction, control specimens revealed detectable signals for neuronal NOS mRNA. In contrast, signals of IHPS specimens were undetectable in five cases and very weak in one. By increasing the PCR to 37 cycles, detectable signals for neuronal NOS mRNA were observed in all IHPS specimens, but they were significantly weaker than those of controls. Since a low level of neuronal NOS mRNA may lead to impaired production of NO, our observations indicate that the excessively contracted, hypertrophied pyloric muscle in IHPS is a result of reduced expression of the neuronal NOS gene at the mRNA level.
    Type of Medium: Electronic Resource
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