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  • 1
    Electronic Resource
    Electronic Resource
    Basic fibroblast growth factor-heparan sulphate complex in the human dialysis-related amyloidosis (1995)
    Springer
    Virchows Archiv 427 (1995), S. 395-400 
    Details
    ISSN: 1432-2307
    Keywords: Basic fibroblast growth factor ; Heparan sulphate ; Beta-2-microglobulin ; Amyloidosis ; Haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A major constituent of the amyloid fibrils in dialysis-related amyloidosis is β2-microglobulin (β2-MG). Heparan sulphates (HS) co-localize with the amyloid fibrils and monocytes/macrophages are commonly found around amyloid deposits, but the role of HS in amyloidogenesis is not yet defined. HS have variable saccharide sequences and can interact specifically with basic fibroblast growth factor (bFGF), a potent chemotactic factor for the monocyte/macrophage. The present investigation was undertaken to look for a functional link between co-localized HS and the pathogenesis of dialysis-related amyloidosis. Using amyloid-enriched ligament, immunohistochemical localization was tested for β2-MG, endogenous bFGF, and bFGF-binding portions of HS. For the detection of bFGF-binding portions of HS, the ligament sections were incubated with exogenous bFGF and then with anti-bFGF antibody. The specificity of the interaction between bFGF and HS was established by confirming a concomitant loss of immunoreactivity during selective removal of HS with heparitinase. β2-MG, endogenous bFGF, and bFGF-binding portions of HS were detected between bundles of collagen. Endogenous bFGF and bFGF-binding portions of HS were not detected in more advanced amyloid lesions, whereas β2-MG and other portions of HS were detected. We propose that β2-MG, endogenous bFGF, and bFGF-binding portions of HS form a complex and localize in the early amyloid lesions of dialysis-related amyloidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199388
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  • 2
    Electronic Resource
    Electronic Resource
    Hypercalcemia associated with parathyroid hormone-related protein produced by B-cell type primary malignant lymphoma of the kidney (1998)
    Springer
    Annals of hematology 76 (1998), S. 221-224 
    Details
    ISSN: 1432-0584
    Keywords: Key words Hypercalcemia ; PTHrP ; B-cell lymphoma ; Bisphosphonate ; Kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A patient with primary non-Hodgkin's (B-cell type) lymphoma of the kidney developed hypercalcemia at the terminal stage of the disease. Although the plasma parathyroid hormone level was low, urinary cyclic AMP excretion was elevated. Serum osteocalcin (BGP) was suppressed and the plasma level of 1,25(OH)2D was within the normal range. Serum concentrations of PTH-related protein (PTHrP)-like immunoreactivity (PRP-LI) were elevated, and the tissue concentration of PRP-LI in the postmortem lymph node showed high level along with elevated serum PRP-LI, furthermore the production of PTHrP by the tumor was demonstrated by immunohistochemistry and Northern blotting analysis. These findings indicate that the hypercalcemia of the patient was caused by the PTHrP-producing B-cell lymphoma. Hypercalcemia was restored to normocalcemia by bisphosphonate treatment. Our case will add further information on humoral hypercalcemia in B-cell lymphoma, which rarely has been demonstrated to produce PTHrP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050393
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A Comparison of Photosynthetic Capacity between Myrica Gale var. Tomentosa a Nitrogen-Fixing Shrub, and Co-Occurring Species in an Oligotrophic Moor (1999)
    Springer
    Photosynthetica 36 (1999), S. 11-20 
    Details
    ISSN: 1573-9058
    Keywords: areal leaf mass ; Betula platyphylla var. japonica ; irradiance ; diurnal course ; intercellular CO2 concentration ; leaf nitrogen content ; net photosynthetic rate ; Rhododendron japonicum ; stomatal conductance ; transpiration rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Photosynthetic and transpiration (E) rates, stomatal conductance, and leaf nitrogen content were surveyed for Myrica gale var. tomentosa, a N2-fixing wetland shrub, Betula platyphylla var. japonica, and Rhododendron japonicum in Ozegahara moor, an oligotrophic moor in Central Japan. Net photosynthetic rate saturated with irradiance (Pmax) of M. gale was 15.2-16.5 μmol(CO2) m-2 s-1, higher than those of the other species throughout the growing season. Pmax was positively correlated with leaf N content among the three species. The large leaf N content in M. gale was due to N2-fixation in root nodules. In a comparison of M. gale in two habitats, Pmax, leaf N content, and root nodule development were larger in the wetter habitat. M. gale showed high E and no midday depression of Pmax even under high irradiance and large vapour pressure deficit between leaves and ambient air on a midsummer day. These traits of photosynthesis and water relations were associated with the dominance of this shrub in wetter sites such as stream sides and hollows.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007054317290
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    Paper (German National Licenses)
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