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  • 1
    Electronic Resource
    Electronic Resource
    Cure of Helicobacter pylori infection in the elderly: effects of eradication on gastritis and serological markers (1996)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Specific data on anti-H. pylori treatments in elderly people are very scarce. The aim of the study was to evaluate in the elderly the efficacy of different anti-H. pylori therapies and the behaviour of serum anti-H. pylori antibodies, pepsinogen A and C, and PGA/PGC ratio induced by the anti-H. pylori treatment. Methods: One hundred and twenty-one dyspeptic patients aged 〉60 years (mean age, 73 years; range, 61–89 years) with H. pylori-positive gastric ulcers (17 patients), duodenal ulcers (33 patients) or chronic gastritis (71 patients) were treated with one of the following anti-H. pylori treatments: (A) omeprazole 20 mg/day plus azithromycin 500 mg/day for 3 days; (B) omeprazole 20 mg/day plus azithromycin 500 mg/day for 3 days plus metronidazole 250 mg q.d.s. for 7 days; (C) omeprazole 40 mg/day plus azithromycin 500 mg/day for 3 days plus metronidazole 250 q.d.s. for 7 days; (D) omeprazole 20 mg/day plus clarithromycin 250 b.d. for 7 days; (E) omeprazole 20 mg/day plus clarithromycin 250 b.d. for 7 days plus metronidazole 250 q.d.s. for 7 days; and (F) omeprazole 40 mg/day plus clarithromycin 250 mg b.d. for 7 days plus metronidazole 250 mg q.d.s. for 7 days. At the baseline and 2 months after therapy, endoscopy and serum anti-H. pylori antibodies, pepsinogen A and C, and PGA/PGC ratio were measured. Results: Ten patients (8.2%) dropped out of the study. Six patients (4.9%) reported side-effects. The eradication rates of the six regimens, expressed using intention-to-treat and per protocol analysis, were, respectively: (A) 39% and 44%; (B) 50% and 56%; (C) 65% and 77%; (D) 47% and 50%; (E) 85% and 90%; and (F) 83% and 87%. The triple therapy for regimens E and F was significantly more effective than dual therapies (regimens A and D; intention-to-treat=P〈0.007, per protocol=P〈0.001) or the triple therapy for regimens B and C (intention-to-treat=P〈0.009, per protocol=P〈0.03). Patients cured of H. pylori infection showed a significant decrease in the activity of gastritis (P〈0.0001), a significant drop in IgG anti-H. pylori (P=0.0004) and pepsinogen C (P〈0.0001), and an increase in PGA/PGC ratio (P〈0.001), while patients remaining H. pylori-positive showed no changes in the serum parameters. Conclusions: In the elderly, triple therapy with omeprazole +metronidazole+clarithromycin for 1 week is well tolerated and highly effective; anti-H. pylori antibody and PGC serum levels decrease soon after anti-H. pylori therapy only in patients cured of H. pylori infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1996.88260000.x
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  • 2
    Electronic Resource
    Electronic Resource
    Richards-Rundle syndrome, cochleovestibular dysfunction and neurofibromatosis in a family (1984)
    Springer
    Journal of neurology 231 (1984), S. 11-13 
    Details
    ISSN: 1432-1459
    Keywords: Richards-Rundle syndrome ; Cochleovestibular dysfunction ; Neurofibromatosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Richards-Rundel-Syndrome (RRS) ist durch Gehörstörung, psychischen Abbau, Ataxie und primären Hypogonadismus charakterisiert und wird autosomal rezessiv vererbt. Unter sechs Geschwistern fanden wir zwei Schwestern mit dem RRS und zusätzlich Kahlheit, verminderter GH und PRL Sekretion nach Stimulierung sowie in unterschiedlichem Ausmaß auch eine verminderte Insulinsekretion. Eine Untersuchung des cochleovestibulären Apparates bei allen Geschwistern zeigte bei jedem mehr oder weniger ausgeprägte, bulbopontin lokalisierte cochleovestibuläre Funktionstörungen. Drei Mitglieder der gleichen Geschwisterschaft hatten Hautsymptome einer abortiven Neurofibromatose und der Sohn eines der Geschwister hatte eine schwere Form dieser Krankheit. Es bleibt allerdings noch offen, ob ein pathogenetischer Zusammenhang zwischen der erblichen multisystemischen Degeneration des RRS, der Dysembriopathie Neurofibromatose und der cochleovestibulären Funktionsstörung in der hier beschriebenen Familie besteht.
    Notes: Summary The Richards-Rundle syndrome (RRS) is characterized by hearing loss, mental deterioration, ataxia, primary hypogonadism and autosomal recessive transmission. In a sibship of six members we found two sisters with RRS together with baldness, impaired GH and PRL secretion after stimulation and different degrees of impaired insulin secretion. Cochleovestibular investigation of the sibship revealed in each subject more or less severe forms of bulbo-pontine cochleovestibular dysfunction. Three members of the same sibship had cutaneous signs of abortive forms of neurofibromatosis: the son of one of these subjects had a severe form of fully developed neurofibromatosis. Whether there is a pathogenetic linkage between the hereditary multisystemic degeneration (RRS), the dysembryopathy (neurofibromatosis) and the cochleovestibular dysfunction in this family is still not clear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313645
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  • 3
    Electronic Resource
    Electronic Resource
    Differential distribution of striatal [123I]β-CIT in Parkinson’s disease and progressive supranuclear palsy, evaluated with single-photon emission tomography (1998)
    Springer
    European journal of nuclear medicine 25 (1998), S. 1270-1276 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Iodine-123-β-CIT ; Single-photon emission tomography ; Extrapyramidal disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Functional imaging of the presynaptic dopaminergic activity using single-photon emission tomography (SPET) and iodine-123 labelled 2-β-carboxymethoxy-3-β-(4-iodophenyl)tropane ([123I]β-CIT) is important for the assessment of disease severity and progression in patients with Parkinson’s disease (PD). However, its capability to discriminate between different extrapyramidal disorders has not yet been assessed. The aim of this study was to evaluate the possibility of differentiating patients with PD and with progressive supranuclear palsy (PSP) by means of this method. The distribution of [123I]β-CIT in the basal ganglia was assessed in six normal subjects, 13 petients with PD and five patients with PSP in whom the disease was mild. SPET images were obtained 24±2 h after i.v. injection of the tracer using a brain-dedicated system (CERASPECT). MR and SPET images were co-registered in four normal subjects and used to define a standard set of 16 circular regions of interest (ROIs) on the slice showing the highest striatal activity. The basal ganglia ROIs corresponded to (1) the head of caudate, (2) a region of transition between the head of caudate and the anterior putamen, (3) the anterior putamen and (4) the posterior putamen. A ratio of specific to non-displaceable striatal uptake was calculated normalising the activity of the basal ganglia ROIs to that of the occipital cortex (V3′′). ANOVA revealed a global reduction of V3′′ in all ROIs of PD and PSP patients compared with normal controls (P〈0.0001). A Mann-Whitney U test showed that the difference between PD and PSP patients was statistically significant for the caudate region only (Z value: 2.6; P〈0.01). By subtracting V3′′ caudate values from those of the putamen, differentiation from PSP was possible in 10/13 PD patients. In conclusion, analysis of [123I]β-CIT distribution in discrete striatal areas provides information on the relative caudate-putamen damage, with different values being obtained in patients clinically diagnosed as having either PD or PSP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050295
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  • 4
    Electronic Resource
    Electronic Resource
    Population structure in Sardinia on the basis of quantitative palmar dermatoglyphic traits (1998)
    Springer
    International journal of anthropology 13 (1998), S. 57-64 
    Details
    ISSN: 1824-3096
    Keywords: Sardinia, population structure ; dermatoglyphic traits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We describe the genetic structure of twenty Sardinian subpopulations using quantitative palmar dermatoglyphic traits (a-b, and A-d counts, atd angle value, coefficient of Turpin and Lejeune, main line index, mean of A-, B-, C, and D-line terminations) of 3777 subjects (2043 males and 1734 females). The twenty subdivisions represent sixteen historical-geographic areas of the island in which people speaks Sardinian language, Sassarese and Gallura areas in which people speaks two Italian dialects, and the two communities of Alghero (Catalan speaking) and Carloforte (Ligurian speaking). Analysis was carried out for both hands and both sexes combined and using R-matrix technique and the extension of the Harpending-Ward model to quantitative traits according to Relethford & Blangero (1990). Multivariate minimum Fst value (0.0127) is higher than that of most. Mediterranean populations and shows the importance of isolation and genetic drift as evolutive forces at the basis of microdifferentiation among the Sardinian subpopulations considered. However, when the four populations not speaking Sardinian language are removed from the analysis, the value of Fst decreases to 0.008. The regression of mean genetic variance on distances from the centroid (rii values) states the marked effect of the genetic drift for Nuorese and Barbagia di Ollolai subdivisions (placed in the inner and mountainous areas of Sardinia) and reveals considerable levels of admixture for Carloforte subdivision. The contemporary genetic structure of these groups reflects their historical, linguistic and geographic characteristics. On the whole, our analysis confirms the usefulness of quantitative dermatoglyphic traits in studying genetic population structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442250
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  • 5
    Electronic Resource
    Electronic Resource
    Ethical problems relating to clinical research involving demented subjects and ethics committees (1997)
    Springer
    Neurological sciences 18 (1997), S. 53-56 
    Details
    ISSN: 1590-3478
    Keywords: dementia ; ethics committee
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario In questo articolo viene presentata l'esperienza del Comitato Etico dell'Ospedale San Raffaele di Milano con particolare riguardo ai problemi etici che sorgono nella conduzione di ricerche in pazienti affetti da demenza.
    Notes: Abstract In this paper the authors discuss the approach of San Raffaele's Hospital Ethics Committee with regard to ethical problems relating to clinical research involving demented subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02048208
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