ISSN:
1573-8752
Keywords:
Stereotactic radiosurgery
;
brain tumors
;
radiobiology
;
pathology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A total of 235 lesions in 187 patients were treated radiosurgically, including 71 primary malignant brain tumors, 113 metastases, 38 arteriovenous malformations, and 13 benign brain tumors. Postradiosurgery tissue was obtained from 36 lesions in 32 of these patients (17% of total) who developed radiographic or clinical progression/necrosis—entailing 27 resections/biopsies and 9 autopsies. Of these 32 patients, 18 had primary malignant brain tumors, 11 had metastasis, and 3 had benign brain tumors. Central or peripheral residual tumor was seen in 27 of 36 (75%) specimens, including 75% of metastases, 80% of malignant brain tumors, and 50% of benign brain lesions. Residual disease was designated to be central or peripheral to the radiosurgery target. Among primary brain malignancies, the 6- and 12-month actuarial risk for persistent central/peripheral tumor was 70/75% and 55/90%, respectively. For metastatic lesions, the 6- and 12-month actuarial risk for persistent central/peripheral tumor was 60/82% and 55/82% respectively. Radiographic changes consistent with progression were confirmed histopathologically in 75% of cases and viable tumor was most common at the periphery, correlating with lower isodose lines.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/B:JORA.0000015195.83775.fc
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