Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1995-1999  (1)
  • 1975-1979  (1)
  • 1950-1954
  • Arachidonic acid  (1)
  • Deep vein thrombosis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Das Verhalten intraoperativ entstandener tiefer Venenthrombosen, beurteilt anhand wiederholter Phlebographien (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 521-526 
    Details
    ISSN: 1432-1440
    Keywords: Deep vein thrombosis ; phlebography ; postoperative ; fibrinogen test ; postthrombotic syndrom ; Tiefe Venenthrombose ; Phlebographie ; postoperativ ; Fibrinogentest ; postthrombotisches Syndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Rahmen einer prospektiven, randomisierten und kontrollierten Studie, in der die Thromboseprophylaxe-Mittel Dextran und Heparin bei allgemein-chirurgischen und urologischen Patienten geprüft werden, phlebographierten wir 31 Patienten mit sicherer tiefer Venenthrombose sofort nach der Diagnosestellung mittels125J-Fibrinogentest. 16 Patienten wurden 14 Tage später ein zweites Mal phlebographiert.Alle Thromben entstanden intraoperativ. 24 von 31 Patienten zeigten einemultifokale Entstehung der Thromben. Unabhängig vom Prophylaxe-Mittel und der eingeleiteten Therapie machten die Thromben in den ersten 14 Tagen nach deren Entstehung folgende Veränderungen durch: 9 retrahierten sich, 6 verschwanden, ohne Wandveränderungen aufzuweisen, und 1 verschloß das befallene Gefäß noch vollständig. 2 Thromben verschwanden ohne jegliche Therapie; 4 weitere unter Heparin- und/oder Phenprocoumonbehandlung.
    Notes: Summary Phlebography was carried out in a prospective randomised, controlled study during which dextran and small doses of s.c. heparin have been compared in general surgical and urological patients, in 31 persons with proven deep vein thrombosis diagnosed with the125I-fibrinogen test. In 16 out of the 31 patients a second phlebogram could be performed two weeks later. In this study all thrombi occurred intraoperatively. In 24 of the 31 patients, the appearance of thrombi was multilocular. Independent of the prevention instituted and irrespective of the therapy, the following phenomena could be seen 14 days after the first phlebogram: 9 thrombi retracted, 6 disappeared completely and 1 occluded the vein completely. 2 thrombi disappeared without any therapy whatsoever, the 4 others disappeared in patients receiving heparin and/or coumarin for treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468973
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Modulation of neuronal calcium channels by arachidonic acid and related substances (1995)
    Springer
    The journal of membrane biology 145 (1995), S. 233-244 
    Details
    ISSN: 1432-1424
    Keywords: Ca2+ current ; Arachidonic acid ; Myristic acid ; Tetradecyltrimethylammonium ; Sphingosine ; Neuroblastoma x glioma hybrid cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Low-voltage-activated (1-v-a) and high-voltage-activated (h-v-a) Ca2+ currents I Ca were recorded in whole-cell voltage clamped NG108-15 neuroblastoma x glioma hybrid cells. We studied the effects of arachidonic acid (AA), oleic acid, myristic acid and of the positively charged compounds tetradecyltrimethyl-ammonium (C14TMA) and sphingosine. At pulse potentials 〉−20 mV, AA (25-100 μm) decreased 1-v-a and h-v-a I Ca equally. The decrease developed slowly and became continually stronger with increasing time of application. It was accompanied by a small negative shift and a slight flattening of the activation and inactivation curves of the 1-v-a I Ca. The shift of the activation curve manifested itself in a small increase of 1-v-a I Ca at pulse potentials 〈−30 mV. The effects were only partly reversible. The AA effect was not prevented by 50 μm 5, 8, 11, 14-eicosatetraynoic acid, an inhibitor of the AA metabolism, and not mimicked by 0.1–1 μm phorbol 12, 13-dibutyrate, an activator of protein kinase C. Probably, AA directly affects the channel protein or its lipid environment. Oleic and myristic acid acted similarly to AA but were much less effective. The positively charged compounds C14TMA and sphingosine had a different effect: They shifted the activation curve of 1-v-a I Ca in the positive direction and suppressed 1-v-a more than h-v-a I Ca; their effect reached a steady-state within 5–10 min and was readily reversible. C14TMA blocked 1-v-a I Ca with an IC50 of 4.2 μm while sphingosine was less potent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232715
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...