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  • 1995-1999  (2)
  • 1975-1979  (1)
  • 1920-1924  (4)
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  • 1
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 114 (1924), S. 717-718 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] IT is known that the atomic weights of such radio-elements as have been determined experimentally agree approximately with those to be expected on radioactive theory, and also that small unexplained discrepancies appear when the actual instead of the approximate values are considered. The ...
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 112 (1923), S. 619-620 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] IT was suggested by the writer in 1912 that the end-products of the uranium and thorium disintegration series should differ in atomic weight from that of common lead, which chemically they closely resemble. As the atomic weights of these products, determined experimentally later by Richards and ...
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 112 (1923), S. 588-589 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] SOME months ago, when engaged on a study of radioactive disintegration series, the results of which appeared in the October issue of the Philosophical Magazine, I was able to formulate simple rules from radioactive data which enabled me to calculate a list of the atomic weights of the principal ...
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 111 (1923), S. 703-704 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] AT present the most likely view of the origin of the actinium series is that uranium II undergoes a dual change in which about 96 per cent, of atoms form ionium and the radium series, and the remainder form uranium Y, the product of which, proto-actinium, is the parent of the actinium series. ...
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Digestive diseases and sciences 20 (1975), S. 359-361 
    ISSN: 1573-2568
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The complete HL-A antigen profile was examined in 77 patients with Crohn's disease, 11 of whom had unequivocal ankylosing spondylitis. There was no significant difference in the frequencies of the HL-A antigens between these 77 patients and 600 normal controls. 10 male patients with Crohn's disease possessed HL-Aw27; all of these had unequivocal ankylosing spondylitis. This antigen may, therefore, be a useful marker of spondylitis in Crohn's disease.
    Materialart: Digitale Medien
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  • 6
    ISSN: 1434-9949
    Schlagwort(e): Fibromyalgia ; Adverse Effects ; P450IID6 Polymorphism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Objective: To assess the frequency of adverse drug reaction in patients with fibromyalgia in relation to medications prescribed for this condition. To evaluate the potential role of the P450IID6 phenotype in the pathogenesis of these adverse drug reactions. Methods: Thirty-five patients with fibromyalgia were assessed using a structured questionnaire with demographic and clinical data and perceived adverse drug reactions. A sample of 60 patients with rheumatoid arthritis and 62 patients with localized back pain served as controls. The P450IID6 phenotype was determined for each of the fibromyalgia patients. Results: Overall, 141 patients had used NSAID and 79 (56%) of them reported adverse effects. Antidepressant drugs were used by 68 patients and 35 (51%) patients had adverse effects. Muscle relaxant drugs were used by 48 patients and 15 (31%) of them reported side effects. Analgesics were used by 122 patients and 22 (18%) had experienced adverse effects. Statistical differences in the frequency of adverse effects were found with antidepressant drugs in the fibromyalgia group, compared with rheumatoid arthritis (p=0.01) and back pain (p=0.02). Four of the 35 patients (11.4%) had a metabolic ratio (M.R.) greater than 0.30 (log M.R.=−0.52) indicative of the poor metabolizers (PM) phenotype. M.R. varied from 0.005 (log M.R.=−2.30) to 4.99 (log M.R.=0.70). Conclusions: The problem of adverse drug reactions in fibromyalgia patients does not appear to correlate with the PM phenotype of the P450IID6 oxidative enzyme. It also is unlikely that altered xenobiotic detoxification attributable to this PM phenotype would have a significant role in the development of fibromyalgia.
    Materialart: Digitale Medien
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  • 7
    ISSN: 1434-9949
    Schlagwort(e): LMP2 ; Ankylosing Spondylitis ; Disease Severity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Although a number of reports have now described an association between polymorphism of the LMP2 gene and disease phenotype in HLA-B27 positive individuals with ankylosing spondylitis (AS), some describe associations with acute anterior uveitis, others with juvenile onset disease, and one report provides no association. A recent study describes yet a further association with disease severity in patients with juvenile rheumatoid arthritis. We therefore hypothesized that the discrepant findings in adult disease may be a reflection of an underlying association with disease severity. Our study population consisted of 100 HLA-B27 positive Caucasians with AS of ten or more years duration. Clinical assessment of disease severity was based on a metrology index scoring five measurements, the modified health assessment questionnaire for the spondyloarthropathies, and a disease activity index consisting of a visual analog scale to score the amount of pain, stiffness and fatigue. LMP2 genotypes were assigned following polymerase chain reaction amplification from genomic DNA and restriction enzyme digestion with CfoI. Despite confirmation of a significantly higher prevalence of the LMP2 BB genotype in AAU positive (66.0%) versus AAU negative (45.2%) patients (P〈0.05), we observed no association between LMP2 genotypes and any of the indices of disease severity. Furthermore, although a significant association was noted between the presence of peripheral synovitis and the functional index score (P〈0.05), a history of AAU was not associated with more severe disease. Our data is thus internally consistent in demonstrating no association between LMP2 genotypes and either disease severity or peripheral arthritis, and supports the notion that polymorphism of LMP2 primarily influences the development of AAU and not some other phenotype of AS.
    Materialart: Digitale Medien
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