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High speed molecular weight distribution (1975)

Dark, William A. ; Limpert, Robert J. ; Carter, Jordan D.

Stamford, Conn. [u.a.] : Wiley-Blackwell

Polymer Engineering and Science 15 (1975), S. 831-833

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ISSN: 0032-3888

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: It is now possible to do molecular weight distribution of polymeric material almost as fast as you can put them in solution. μSYRAGEL® has opened a new era in the determination of molecular weight distribution of polymers. With operational efficiencies of 800 plates/min., one can obtain a molecular weight distribution in 15 mins. Combining three of the newest advances in liquid chromatography - solvent delivery, septumless injection, and μSYRAGEL - now makes it possible to use molecular weight distribution as a quality control tool in polymerization and fabrication. The reproducibility of the molecular weight distribution is now good enough that overlays can be done from the raw data. The chromatograms can be used right off the recorder. The reproducibility of the weight average and number average molecular weight is 2-3 percent.

Additional Material: 10 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/pen.760151203

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A phase I study of gemcitabine, 5-fluorouracil and leucovorin in patients with advanced, recurrent, and/or metastatic solid tumors (1998)

Berlin, Jordan D. ; Alberti, Dona B. ; Arzoomanian, Rhoda Z. ; [et al.]

Springer

Investigational new drugs 16 (1998), S. 325-330

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ISSN: 1573-0646

Keywords: gemcitabine ; 5-fluorouracil ; leucovorin ; phase I study

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Abstract Introduction: This was a dose escalation phase I trial designed to establish the MTD (maximum tolerated dose) and toxicity profile of the combination of gemcitabine, leucovorin and 5-fluorouracil (5-FU). Methods: Standard eligibility criteria were required for patients with advanced malignancy to enrol. Gemcitabine was escalated from an initial dose of 800 mg/m2. Gemcitabine was administered prior to leucovorin (25 mg/m2) followed by bolus 5-FU (600 mg/m2) every week for 3 weeks followed by 1 week of rest. Results: Of 21 patients enrolled, 20 were eligible for MTD determination. Patients received a median of three 4-week cycles of chemotherapy (range: 1 to 8 cycles). Toxicity was predominantly hematologic or gastroenterologic. Four dose levels were studied. At a gemcitabine dose of 1,500 mg/m2 systemic symptoms of fatigue accompanied hematologic toxicity and patients refused further therapy. At 1,250 mg/m2, full dose intensity was not delivered during the first cycle in 7 of 8 patients treated. Therefore, 1,000 mg/m2 was established as the recommended phase II dose for gemcitabine in this study. Antitumor activity was seen at all dose levels. Conclusions: The combination of gemcitabine, leucovorin and 5-FU was tolerable at full doses of all 3 drugs with an expected toxicity profile. Recommended phase II dose for gemcitabine was 1,000 mg/m2. Initial evidence of clinical activity was seen in a variety of tumor types.