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  • 1995-1999  (4)
  • 1975-1979
  • Immunohistochemistry  (3)
  • Articulation  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Hereditary dentatorubral-pallidoluysian atrophy: detection of widespread ubiquitinated neuronal and glial intranuclear inclusions in the brain (1998)
    Springer
    Acta neuropathologica 96 (1998), S. 547-552 
    Details
    ISSN: 1432-0533
    Keywords: Key words Dentatorubral-pallidoluysian atrophy ; Nuclear inclusion ; Ubiquitin ; Immunohistochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the brains and spinal cords of seven patients with clinicopathologically and genetically confirmed hereditary dentatorubral-pallidoluysian atrophy (DRPLA) using an antibody against ubiquitin, and found small, round immunoreactive intranuclear inclusions in both neurons and glial cells in various brain regions. Ubiquitinated neuronal intranuclear inclusions (uNIIs) were consistently found in the striatum, the pontine nuclei, the inferior olivary complex, the cerebellar cortex and the dentate nucleus. Ubiquitinated glial intranuclear inclusions (uGIIs) were found less frequently than uNIIs. Most of the inclusion-bearing nuclei were of an astrocytic nature. Immunostaining with an antibody against DRPLA protein revealed similar immunoreactive neuronal and glial intranuclear inclusions, but in much smaller in numbers compared with uNIIs and uGIIs. Electron microscopy showed that such inclusions were composed of granular and filamentous structures. These findings strongly suggest that, in DRPLA, the occurrence of uNIIs and uGIIs is directly related to the causative gene abnormality (an expanded CAG repeat encoding polyglutamine), that neurons are affected much more widely than previously recognized and that glial cells are also involved in the disease process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050933
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An unusual meningioma variant with glial fibrillary acidic protein expression (1997)
    Springer
    Acta neuropathologica 94 (1997), S. 499-503 
    Details
    ISSN: 1432-0533
    Keywords: Key words Meningioma ; Immunohistochemistry ; Glial fibrillary acidic protein ; Ultrastructure ; Intercellular lumina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied a recurrent meningioma located in the right frontal lobe. The tumor showed high cellularity and the cells had plump, hyalinous cytoplasm. Immunohistochemically, almost all the tumor cells were positive for epithelial membrane antigen and vimentin, and unexpectedly, glial fibrillary acidic protein (GFAP). Ultrastructural investigation revealed abundant 8- to 10-nm filaments in the cytoplasm. Conspicuous interdigitations with numerous desmosomes were present. Frequently, intracellular and intercellular lumina lined by microvilli were also found. We considered the present case to be an unusual variant of meningioma with GFAP expression. A few cases of meningioma with triple expression of GFAP, vimentin and cytokeratin have been reported previously. However, the present case showed obvious pathological differences from these, and had no immunoreactivity for cytokeratin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050739
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical localisation of stem cell factor (SCF) with comparison of its receptor c-Kit proto-oncogene product (c-KIT) in melanocytic tumours (1995)
    Springer
    Virchows Archiv 427 (1995), S. 283-288 
    Details
    ISSN: 1432-2307
    Keywords: c-KIT ; Immunohistochemistry ; Malignant transformation ; Melanocyte ; SCF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to characterise the distribution and role of stem cell factor (SCF), a recently-reported growth factor for normal melanocytes, we carried out an immunohistochemical study on benign and malignant melanocytic tumours with a comparison with the presence of its receptor c-Kit proto-oncogene product (c-KIT). In normal skin, SCF was mainly observed in endothelial cells of blood vessels but not frequently in basal melanocytes, whereas c-KIT was predominantly localised in tissue mast cells. In benign neoplastic melanocytes (common melanocytic naevi), localisation of SCF and c-KIT was complementary: SCF was mostly found in dermal naevus cells while c-KIT was revealed in epidermal naevus cells, although the expression of the latter antigen was not frequent. Malignant melanoma cells showed less frequent expression of these antigens than those in benign lesions. Of five cultured melanoma cell lines, SCF was observed in only one, and c-KIT was not found in any melanoma cells. No quantitative or qualitative alterations assessed by Western blot analysis were induced in the presence of phenotypic modifiers (sodium butyrate and HMBA). Present data suggest that loss of SCF expression in neoplastic melanocytes is commonly associated with malignant transformation of pigment cells rather than loss of its receptor c-KIT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203396
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Articulation after uvulopalatopharyngoplasty (1996)
    Springer
    European archives of oto-rhino-laryngology and head & neck 253 (1996), S. 417-420 
    Details
    ISSN: 1434-4726
    Keywords: Uvulopalatopharyngoplasty ; Acoustic analysis ; Articulation ; Timbre ; Formant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed perceptual and acoustic studies to demonstrate articulation after uvulopalatopharyngoplasty (UPPP) in Japanese patients at 28.6 days (mean) after surgery (range 21–50 days). The results of listening tests showed that there were no significant changes between pre- and postoperative articulation scores for any of 25 monosyllables tested, and there were no significant changes in the timbres of 5 Japanese vowels after UPPP. In the acoustic study of the first and second formant frequencies of the vowels, some formant frequencies had significant changes after UPPP. However, these changes in formants fell within the range of intraindividual variation. In the acoustic study of /ka/ with a palatal plosive /k/, there was no significant change in the voice onset time or F2 transition after UPPP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168494
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    Paper (German National Licenses)
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