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  • 1
    ISSN: 1432-0533
    Keywords: Key words Amyotrophic lateral sclerosis ; Dentate ; nucleus ; Multiple system degeneration ; Respirator ; Substantia nigra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report concerns an autopsy case of amyotrophic lateral sclerosis (ALS) with unusual clinical and neuropathological findings. The patient was a Japanese man without hereditary burden who was 49 years old at the time of death. His clinical manifestation included dysarthria at age 48, followed by dysphagia, atrophy and fasciculation of the tongue, muscle weakness in the four extremities, tremor, rigidity, increased deep tendon reflexes in the upper and lower extremities, and incoordination of the four extremities. He died of respiratory failure 12 months after the disease onset. No respirator administration was performed throughout the clinical course. The neuropathological examination revealed not only degeneration of upper and lower motor neuron systems, including the presence of Bunina bodies and ubiquitin-immunoreactive neuronal inclusions in the lower motor neurons, but also prominent degeneration of the substantia nigra and dentate nucleus with slight neuronal loss in the locus ceruleus and pontine nucleus. To our knowledge, this is the first reported case of sporadic ALS without dementia and respirator support, showing degeneration of the substantia nigra and dentate nucleus. This report may contribute to the resolution of the question concerning the neuropathological heterogeneity of sporadic ALS with respiratory support.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 3 (1979), S. 37-45 
    ISSN: 1432-5195
    Keywords: Knee ; Osteoarthritis ; Tibial osteotomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Une ostéotomie de l'extrémité supérieure du tibia a été réalisée chez 125 malades (136 genoux) porteurs d'une arthrose sur genu varum. Avant l'intervention, tous les sujets se plaignaient de douleurs plus ou moins importantes et présentaient une augmentation de la déformation lors de l'appui. Le recul est de 1 à 5 ans. Une diminution notable des douleurs a été obtenue sur 112 genoux et 122 malades sont satisfaits de l'intervention. Les genoux stables et indolores ne présentent plus de bâillement externe et ont été en majorité corrigés de façon satisfaisante, avec un angle fémoro-tibial compris entre 165° et 174°. Sur les 28 genoux comportant un angle de 175° à 179° un an après l'opération, 4 ont donné lieu à une récidive du varus trois ans après l'ostéotomie. La mobilité pré-opératoire a été conservée, même dans les cas où une arthrotomie a été associée à l'ostéotomie. Un bilan intraarticulaire, effectué chez 2 malades, plusieurs années après l'ostéotomie, a montré que les parties les plus détruites de la surface articulaire étaient complétement recouvertes d'un tissu fibro-cartilagineux. L'ostéotomie tibiale est efficace dans l'arthrose sur genu varum, surtout si la correction réalise un angle fémoro-tibial de 170°, soit 10° de valgus.
    Notes: Summary High tibial osteotomies were performed on 136 osteoarthritic knees for correction of varus deformity. Before osteotomy all patients experienced moderate or severe pain, and the knees showed lateral thrust on weight-bearing. The patients were followed up for one to five years. Marked relief of pain was obtained in 112 knees, and the patients were satisfied with the result of operation in 122. These painless knees showed no lateral thrust, and in the majority the deformity had been adequately corrected, with post-operative femoro-tibial angles (standing) ranging from 165° to 174°. Four of 28 knees with femoro-tibial angles of 175° to 179°, when measured one year after operation, showed recurrence of varus deformity three years after osteotomy. Preoperative ranges of knee motion were well maintained after osteotomy even when arthrotomy had also been undertaken. Intra-articular assessment in two patients, several years after operation, showed that the most degenerated portions of the articular surface were completely covered by a fibrocartilagenous layer, with no bare bone. High tibial osteotomy is most effective in osteoarthritic knees with varus deformity, when correction is made to a femoro-tibial angle (standing) of 170° (10° valgus).
    Type of Medium: Electronic Resource
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