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  • 1995-1999  (2)
  • 1975-1979
  • Head injury  (1)
  • Numerical Methods and Modeling  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 156 (1997), S. 864-869 
    ISSN: 1432-1076
    Keywords: Key words Carnitine ; Child ; Head injury ; Heart defects ; Sepsis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to characterize the role of carnitine during metabolic stress, we prospectively determined carnitine profiles in plasma and urine on admission, days 2, 5, 10 and 15, among 28 critically ill children free of any known conditions associated with secondary carnitine deficiency. More than 25% of plasma and 50% of urinary carnitine measurements were abnormal; 96% (27/28) of patients displayed on at least one occasion an abnormal [〈−2 SD or 〉+2 SD] carnitine value in plasma. Three children had extremely low [〈10 μmol/l] free carnitine (FC) levels in plasma. Plasma esterified and FC levels on admission were not related to the risk of mortality [PRISM score], to muscle lysis [CK values], and to the caloric intake. Levels of FC and esterified carnitine in plasma were unrelated to those measured in urine. Conclusion Abnormal plasma and urine carnitine measurements are frequently found in critically ill children; the biological significance of these perturbations remains unclear. Caution must be exercised before concluding that an abnormal carnitine value is indicative of an underlying hereditary metabolic disorder in this population.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Communications in Numerical Methods in Engineering 13 (1997), S. 139-149 
    ISSN: 1069-8299
    Keywords: parametric optimization ; finite difference method ; gradient method ; composite structures ; sport equipment ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper describes the implementation of a parametric optimization process in the field of composite structure design. The application concerns alpine skis. Using a reference ski, the process enables the calculation of the optimum shapes for a complete range of skis and checks their behaviour on snow. The objective function is formulated as a least-squares problem involving nine static bending flexibilities of the ski, considered as a simply-supported beam on nine predetermined spans. The composite cross-section properties and the longitudinal profile of the structure are taken into account in a parametric geometry approach. After the homogenization process, integration of the bending equation is carried out using a finite difference approach. The line search procedure uses the gradient method and the descent parameter optimization is carried out using an adapted linear approximation. The discussion of the results highlights the satisfying compromise between precision and calculation time. The procedure constitutes an original implementation of numerical methods in the area of sports equipment. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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