ISSN:
1432-2277
Keywords:
Key words Pancreas transplantation
;
biopsy
;
rejection
;
Biopsy
;
pancreas transplantation
;
rejection
;
Vascular rejection
;
biopsy
;
pancreas
;
Interstitial rejection
;
biopsy
;
pancreas
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To examine the incidence of interstitial and vascular rejection in pancreas allografts and its impact on graft survival, we studied 36 percutaneous pancreas biopsies and 10 pancreas transplantectomy specimens from 32 patients who had undergone simultaneous pancreas-kidney transplantation. Interstitial rejection (IR) was predominantly found in the biopsies, while vascular rejection (VR) was most prominent in the transplantectomies. Pancreas graft survival was significantly decreased for pancreas grafts that had suffered from vascular rejection when compared to those with only interstitial rejection. Potential rejection markers, i. e., serum amylase, glucose, creatinine, and urinary amylase, did not correlate with histological signs of rejection, although increased levels of serum amylase were, in all but one case, associated with rejection.We conclude that a percutaneous pancreas biopsy remains the most reliable method to determine pancreas rejection, and that by distinguishing between IR andVR, a pancreas biopsy may provide important diagnostic as well as prognostic information.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001470050085
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