ISSN:
1435-1463
Keywords:
σ1 Receptor
;
(+)-N-allylnormetazocine
;
1,3-Di(2-tolyl)guanidine
;
microdialysis
;
acetylcholine
;
hippocampus
;
striatum
;
regional differences
;
rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We found that a receptor ligands differentially regulated the acetylcholine (ACh) neurotransmission in the rat brain. Acute administration of (+)-N-allylnormetazocine [(+)-SKF-10,047], a prototype σ1 receptor ligand, and 1,3-di(2-tolyl)guanidine (DTG), a non-specific σ receptor ligand, increased the extracellular ACh level in the rat hippocampus. This increase of hippocampal extracellular ACh level elicited by (+)-SKF-10,047 was more potent than that elicited by DTG. On the other hand, the striatal extracellular ACh level was slightly affected by (+)-SKF-10,047. In addition, DTG did not affect the striatal extracellular ACh level. Our previous studies have shown that both (+)-SKF-10,047 and DTG increased the extracellular ACh level in the rat frontal cortex. Taking all these data into consideration, the regulation of ACh neurotransmission by σ receptor ligands are different depending upon the brain region.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01271226
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