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  • 1995-1999  (2)
  • 1970-1974  (1)
  • Chemistry  (2)
  • Drug abuse  (1)
  • 1
    ISSN: 1432-2072
    Keywords: Ibogaine ; Drug abuse ; Addiction ; Neurotransmitter receptors ; Radioligand binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The indole alkaloid ibogaine (NIH 10567, Endabuse) is currently being examined for its potential utility in the treatment of cocaine and opioid addiction. However, a clearly defined molecular mechanism of action for ibogaine's putative anti-addictive properties has not been delineated. Radioligand binding assays targeting over 50 distinct neurotransmitter receptors, ion channels, and select second messenger systems were employed to establish a broad in vitro pharmacological profile for ibogaine. These studies revealed that ibogaine interacted with a wide variety of receptors at concentrations of 1–100 µM. These included the mu, delta, kappa, opiate, 5HT2, 5HT3, and muscarinic1 and 2 receptors, and the dopamine, norepinephrine, and serotonin uptake sites. In addition, ibogaine interacted withN-methyl-d-aspartic acid (NMDA) associated ion and sodium ion channels as determined by the inhibition of [3H]MK-801 and [3H]bactrachotoxin A 20-α-benzoate binding (BTX-B), respectively. This broad spectrum of activity may in part be responsible for ibogaine's putative anti-addictive activity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 21 (1970), S. 463-473 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Securing screws of stainless steelsThe author emphasizes the importance of screwed connections in technology and discusses the conclusions which must be drawn from existing standards with respect to the utilization of stainless steel screws. Examples are shown to demonstrate the corrosion resistance of such connections (tests in sea water, 3% NaCl, tap water, salt spray) giving prominence to the problems resulting from the use of spring elements (crevice corrosion danger).
    Notes: Der Verfasser betont die Bedeutung der Schraubenverbindungen in der Technik und erörtert die Folgerungen, die sich aus den bestehenden Normen für die Anwendung von Schrauben aus nichtrostenden Stählen ergeben. Anhand won Beispielen wird die hohe Beständigkeit solcher Verbindungen demonstriert (Versuche in Meerwasser, 3% NaCly Leitungswasser, Salzsprühnebel), wobei besonders die Probleme aufgezeigt werden, die sich durch die Verwendung federnder Elemente ergeben (Spaltkorrosion).
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 70 (1998), S. 1108-1108 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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