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  • 1995-1999  (2)
  • 1970-1974
  • Clodronate  (1)
  • EuroQol  (1)
  • 1
    ISSN: 1420-908X
    Keywords: Macrophage ; Liposome ; Spleen ; Depletion ; Clodronate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Small unilamellar vesicles containing clodronate (SUVc) injected intravenously will deplete splenic macrophages and the degree of histological depletion can be assessed by determining the clearance and uptake of monoclonal antibody coated erythrocytes. Splenic Fc dependent clearance, assessed in decomplemented animals, provides a more sensitive index of the effects of large multilamellar liposome encapsulated clodronate (MLVc) and SUVc than does the clearance of complement coated erythrocytes on macrophage depletion in the spleen. MLVc were more efficient than SUVc in inducing a reduction in the number of red pulp macrophages within the spleen. Receptor specific red cell uptake in the spleen could be used as an alternative to histology when assessing splenic macrophage depletion. Encapsulation of clodronate is crucial to its depleting effect since the free drug in saline does not change splenic macrophage number or function.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Quality of life research 5 (1996), S. 521-531 
    ISSN: 1573-2649
    Keywords: EuroQol ; health status measurement ; social preferences ; visual analogue scale
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the clinical and economic evaluation of health care, the value of benefit gained should be determined from a public perspective. The objective of this study was to establish relative valuations attached to different health states to form the basis for a ‘social tariff’ for use in quantifying patient benefit from health care. Three thousand three hundred and ninety-five interviews were conducted with a representative sample of the adult British population. Using the EuroQol health state classification and a visual analogue scale (VAS), each respondent valued 15 health states producing, in total, direct valuations for 45 states. Two hundred and twenty-one re-interviews were conducted approximately 10 weeks later. A near complete, and logically consistent, VAS data set was generated with good test-retest reliability (mean ICC=0.78). Both social class and education had a significant effect, where higher median valuations were given by respondents in social classes III–V and by those with intermediate or no educational qualifications. These effects were particularly noticeable for more severe states. The use of such valuations in a social tariff raises important issues regarding the use of the VAS method itself to elicit valuations for hypothetical health states, the production of separate tariffs according to social class and/or education and the appropriate measure of central tendency.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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