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  • 1970-1974  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 216 (1973), S. 51-60 
    ISSN: 1432-0711
    Keywords: Kalbsuterus ; Estradiol-Receptoren ; DMBA ; Kerntransport ; in vitro-Versuche
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In vitro Experimente mit isolierten Kalbsuteruskernen in Tris-EDTA-Puffer Lösungen oder Uterus Cytosol zeigten, daß sowohl Oestradiol-17β (E 2) wie 7,12-Dimethylbenz(a)antracen (DMBA) in den Kern transportiert wird. Eine spezifische Bindung an Kernreceptoren konnte dabei nicht festgestellt werden. Weiterhin untersuchten wir den gegenseitigen Einfluß von DMBA auf den Transport vonE 2 in den Kern. Dabei fand sich kein Einfluß auf den Transport oder auf die Menge der transportierten Substanzen.
    Notes: Summary In vitro incubation experiments with isolated nuclei from calf uteri in Tris-EDTA buffer or in uterine cytosol have shown, that 7,12-dimethylbenz(a)-anthracene (DMBA) was transported into the nuclei. However, a specific binding to nuclear receptors could not be found. Furthermore the influence of DMBA on the estradiol-17β (E 2) transport into the nuclei and vice versa was studied. In both cases no influence on the transport rate or on the amount of transportedE 2 or DMBA into the nuclei could be demonstrated.
    Type of Medium: Electronic Resource
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