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  • 1995-1999  (1)
  • 1970-1974  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Transport von 17β-Oestradiol und 7,12-Dimethylbenz(a)anthracen in Uteruskerne in vitro (1973)
    Springer
    Archives of gynecology and obstetrics 216 (1973), S. 51-60 
    Details
    ISSN: 1432-0711
    Keywords: Kalbsuterus ; Estradiol-Receptoren ; DMBA ; Kerntransport ; in vitro-Versuche
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In vitro Experimente mit isolierten Kalbsuteruskernen in Tris-EDTA-Puffer Lösungen oder Uterus Cytosol zeigten, daß sowohl Oestradiol-17β (E 2) wie 7,12-Dimethylbenz(a)antracen (DMBA) in den Kern transportiert wird. Eine spezifische Bindung an Kernreceptoren konnte dabei nicht festgestellt werden. Weiterhin untersuchten wir den gegenseitigen Einfluß von DMBA auf den Transport vonE 2 in den Kern. Dabei fand sich kein Einfluß auf den Transport oder auf die Menge der transportierten Substanzen.
    Notes: Summary In vitro incubation experiments with isolated nuclei from calf uteri in Tris-EDTA buffer or in uterine cytosol have shown, that 7,12-dimethylbenz(a)-anthracene (DMBA) was transported into the nuclei. However, a specific binding to nuclear receptors could not be found. Furthermore the influence of DMBA on the estradiol-17β (E 2) transport into the nuclei and vice versa was studied. In both cases no influence on the transport rate or on the amount of transportedE 2 or DMBA into the nuclei could be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00672674
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation (1999)
    Springer
    Histochemistry and cell biology 111 (1999), S. 453-459 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  S100 proteins, a subgroup of the EF-hand Ca2+-binding protein family, regulate a variety of cellular processes via interaction with different target proteins. Several pathological disorders, including cancer, are linked to altered Ca2+ homeostasis and might involve the multifunctional S100 proteins, which are expressed in a cell- and tissue-specific manner. The present work demonstrates a distinct intracellular localization of S100A6, S100A4, and S100A2 in two tumor cell lines derived from metastatic epithelial breast adenocarcinoma (MDA-MB231) and cervical carcinoma (HeLa). Treatment of the cells by thapsigargin, the ionophore A23187, or cyclic ADP-ribose, to increase [Ca2+]i via different pathways, led to relocation of S100A6 and S100A4 but only partially of the nuclear S100A2, as demonstrated by confocal laser scanning microscopy. These findings support the hypothesis that S100 proteins could play a crucial role in the regulation of Ca2+ homeostasis in cancer cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004180050381
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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