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  • 1
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Information, technology & people 9 (1996), S. 63-77 
    ISSN: 0959-3845
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Computer Science , Sociology
    Notes: The current software crisis has created a situation where organizations are faced with identified as well as hidden information systems (IS) development backlogs. IS projects are generally behind schedule and/or over budget. Even after implementation, the IS does not necessarily solve all the original problems and is very difficult and costly to use and maintain. Software development and maintenance costs represent the major component of total information technology (IT) budget. Reports on research conducted in Singapore which addresses the question concerning the identification of the skills of systems analysts. Analyses this question from three different viewpoints (interviews about "excellent" systems analyst, newspaper advertisements for systems analyst positions, and a questionnaire regarding hiring, promotion, evaluation and training criteria for systems analysts). The research suggests that there is a discrepancy between the criteria established for the initial screening of candidates and the actual process followed for selection, evaluation, training and promotion of systems analysts. This discrepancy will result in the less than optimal use of systems analyst personnel and may be a contributing factor to the current IS software crisis. While the research was conducted solely in Singapore, it is contended that the results are generally applicable because of the emergence of what is referred to as an "occupational community" of systems analysts.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-3023
    Keywords: Bladder retraining ; Incontinence ; Outpatient ; Physiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventy-four patients presenting with a mixed pattern of urinary symptoms were randomly allocated to undergo either inpatient or outpatient continence programs as initial treatment, without prior urodynamic investigation. Both programs consisted of physiotherapy, bladder retraining, fluid normalization, dietary advice and general support and advice. Nine out of 39 in the outpatient group and 8 out of the 35 of the impatient group failed to complete the study. There was a significant decrease in frequency, nocturia, number of incontinent episodes and visual analog scores for both groups. In addition the outpatients had a significant reduction in loss on pad testing, and a significantly greater improvement in their visual analog score. In each group 63% were cured or improved to the extent that they did not require further treatment. Staff costs per outpatient were half those for an inpatient. We conclude that outpatient conservative treatment as detailed above is a successful first-line treatment of urinary incontinence in women. It is as successful and possibly better than inpatient treatment, and is significantly cheaper.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 434 (1997), S. 151-158 
    ISSN: 1432-2013
    Keywords: Key words Inward rectifier ; Voltage-dependent block ; Distal nephron ; Selectivity ; Anomalous mole fraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  ROMK1 is an inwardly rectifying K+ channel cloned from the outer medulla of rat kidney. We have determined the permeation and blocking characteristics for several monovalent cations in ROMK1 when expressed in Xenopus oocytes, using the two-electrode voltage-clamp technique. The selectivity sequence for monovalent cations as determined by reversal potential changes under bi-ionic conditions was K+ 〉 Rb+ 〉 Cs+ = NH4+ 〉〉 Na+ = Li+. The conductivity for the two permeant ions K+ and Rb+ was a saturable function of the external concentration, with K m values of 11.5 ± 1.3 mmol l–1 (n = 19) and 47.3 ± 4.8 mmol l–1 (n = 19), respectively. With mixtures of K+ and Rb+, the conductance went through a clear minimum as the concentration ratio [Rb]/[K+Rb] was varied between 0 and 1. ROMK1 was blocked by both Cs+ and Ba2+ in a concentration- and voltage-dependent manner. The electrical distance (δ) at which Ba2+ and Cs+ blocked the channel was 0.41 and 0.69, respectively, suggesting that these two ions block at different sites within the pore. Taken together with previous reports, the results indicate that ROMK1 has a multi-ion pore, and that the N-terminus contributes to the pore structure.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 24 (1995), S. 117-121 
    ISSN: 1432-2161
    Keywords: Glenoid labrum ; Magnetic resonance imaging ; Three-dimensional volume scan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to assess the accuracy of three-dimensional (3D) magnetic resonance imaging (MRI) reformation in the evaluation of tears of the glenoid labrum complex (GLC). Fifty-five shoulders were evaluated by MRI using standard spin-echo sequences. Gradient-refocused-echo axial projections were used to assess the GLC on the two-dimensional (2D) studies. Three-dimensional Fourier transform multiplanar gradient-recalled imaging with a resolution of 0.7 mm was also performed in all patients. Independent analyses of the anterior and posterior labra were performed in a blinded manner for both the 2D and 3D studies by three experienced musculoskeletal radiologists. Observations of the imaging studies were compared with the videoarthroscopic findings. The appearance of the GLC was rated on a scale of 0 to 4 (0–2=normal, 3, 4=abnormal or torn). The diagnostic confidence was averaged from the three reader's scores. Anterior labral tears were effectively detected with sensitivities of 89% and 96% and specificities of 96% and 100% (P〈0.0001) for the 2D and 3D studies, respectively. For posterior labral tears, the sensitivity and specificity of the 2D method were 47% and 98%, respectively. The sensitivity and specificity of the 3D volume sequence were 53% and 98%, respectively. The lower sensitivity of both imaging methods for detecting posterior labral tears may be influenced by the smaller number (n=5) of arthroscopically confirmed cases in our study and reflects the difficulty of viusalizing the posteroinferior borders of the GLC with present MRI techniques.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1433-3023
    Keywords: Bladder retraining ; Incontinence ; Physiotherapy ; Urodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixty patients complaining of frequency, urgency, nocturia, urge incontinence and stress incontinence were randomly allocated to either undergo conservative treatment by way of combined physiotherapy and bladder retraining as an inpatient without prior urodynamics, or to have urodynamic investigations and treatment tailored to the urodynamic diagnosis. The assessment period was 3 months and assessment was made pre- and posttreatment by urinary diary, pad testing and subjective questionnaire. There was a significant improvement posttreatment for each parameter studied, with the exception of pad testing. There was no significant difference between the two groups for any parameter. Two-thirds of patients were cured to the extent that they did not require further treatment, and again there was no difference between the two groups. We conclude that patients attending for the first time with an uncomplicated story of urinary incontinence can be effectively treated conservatively without prior urodynamics.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Antonie van Leeuwenhoek 38 (1972), S. 351-356 
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effect of age of a culture ofSarcina flava on the chemical composition of the total membrane fraction has been investigated. Both protein and lipid contents decrease with age, but there is little variation in carbohydrate content. The apparent decreased lipid content may be a reflection of the increased binding of lipid to protein with age. The main findings from the amino acid analysis of three membrane preparations are reported. The major carbohydrates present in the membrane are, in order of decreasing concentration, mannose, glucose, ribose and rhamnose.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Asia Pacific journal of management 13 (1996), S. 25-46 
    ISSN: 1572-9958
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract Within the broad context of Singapore's IT2000 Project, an exploratory research project was conducted as part of an on-going program to identify the perceptions of what constitutes the qualities of an “excellent” systems analyst. A grounded theory approach (theory building) was adopted using Kelly's RepGrid technique to conduct interviews with stakeholders in the systems analyst's performance in a large organization based in Singapore. In reviewing the constructs which emerged from the stakeholder interviews, 12 universal Themes were identified, such as Attitude, Knowledge, Communicate, including a number of sub-Themes. Each stakeholder group had its own interpretation of the relative importance of each Theme. These results have implications for the selection, training and development of systems analysts. Suggestions are made for further research to compare the cross-cultural perceptions of “excellent” systems analysts, as well as the testing of specific hypotheses derived from the results of this research project.
    Type of Medium: Electronic Resource
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