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  • 1995-1999  (1)
  • 1970-1974  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 146 (1996), S. 253-263 
    ISSN: 1420-9136
    Keywords: Fracture ; fault nucleation ; critical crack density ; hierarchic failure ; earthquakes ; thermal activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract In this paper we propose a two-stage model of rock fracture. In the first stage, cracks or local regions of failure are uncorrelated and occur randomly throughout the rock in response to loading of pre-existing flaws. As damage accumulates in the rock, there is a gradual increase in the probability that large clusters of closely spaced cracks or local failure sites will develop. Based on statistical arguments, a critical density of damage will occur where clusters of flaws become large enough to lead to larger-scale failure of the rock (stage two). While crack interaction and cooperative failure is expected to occur within clusters of closely spaced cracks, the initial development of clusters is predicted based on the random variation in pre-existing flaw populations. Thus the onset of the unstable second stage in the model can be computed from the generation of random, uncorrelated damage. The proposed model incorporates notions of the kinetic (and therefore time-dependent) nature of the strength of solids as well as the discrete hierarchic structure of rocks and the flaw populations that lead to damage accumulation. The advantage offered by this model is that its salient features are valid for fracture processes occurring over a wide range of scales including earthquake processes. A notion of the rank of fracture (fracture size) is introduced, and criteria are presented for both fracture nucleation and the transition of the failure process from one scale to another.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 77 (1972), S. 1-8 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde der DNS-Umsatz in den Organen von mit solid-wachsendem ELD-Krebs inokulierten Mäusen mittels 14C-Thymidin studiert. Bei einer Tumorgröße von 13% des Körpergewichtes ist das Gesamtkörpergewicht unverändert somit eine relative Kachexie anzeigend. Das Darmfett nahm ab. Leber und Milz zeigten Gewichtszunahme und deutliche Zeichen gesteigerter DNS-Synthese. Die übrigen Organe zeigten keine signifikanten Veränderungen im Zellumsatz. In Nieren und Muskeln ließ sich eine kurzfristige Stimulation der DNS-Synthese kleinerer Zellpopulationen als unmittelbare Folge der Krebsinoculation wahrscheinlich machen. Frühzeitiger Aktivitätsabfall in der Milz im Verein mit gleichzeitigem Anstieg in Leber, Nieren und Muskeln kann auf Zellwanderung hindeuten.
    Notes: Summary The turnover of DNA was studied by means of thymidiny14C in different organs of mice inoculated with solid growing ELD tumor. At a tumor size of 13% of body weight, total body weight is unchanged indicating relative kachexiay The mesenteric fat decreased. The liver and spleen increased in weight, a change that was accompanied by increased DNA synthesis. The DNA-turnover of all other organs remained unchanged. In the kidneys and muscles smaller cell populations were stimulated by the tumor inoculation to a transitory increase of DNA-synthesis. An early decrease of label in the spleen and a concomitant increase in the liver, kidney and muscle may indicate cell migration.
    Type of Medium: Electronic Resource
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