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  • 1
    Electronic Resource
    Electronic Resource
    Irradiation-induced improvement of crystalline quality of epitaxially grown Ag thin films on Si substrates (1996)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 69 (1996), S. 2828-2830 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report the Rutherford backscattering spectroscopy/channeling studies of epitaxial grown Ag films on Si(100) substrates irradiated with fast ions (12C++, 19F++, 28Si++) in the energy range between 0.5 and 4 MeV at 200 and −150 °C. The quality of the Ag films is improved considerably by ion irradiation. Irradiation with 0.5 MeV 28Si ions to 2×1016/cm2 at 200 °C, for example, reduces the channeling minimum yield from 55% to 6% at the Ag surface. The improvement of crystalline quality is brought about by a decrease in mosaic spread in the Ag film. Also, it is found that the higher the crystallinity, the more radiation-induced defects are produced. The mechanism involved in the irradiation-induced improvement is discussed. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.117332
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  • 2
    Electronic Resource
    Electronic Resource
    ENDOTHELINS CONTRACT GUINEA-PIG PULMONARY ARTERY AND ENHANCE ITS ADRENERGIC RESPONSE VIA ETA RECEPTORS (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 23 (1996), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. This study has pharmacologically characterized endothelin (ET) receptor subtype(s) mediating contraction and enhancement of adrenergic contraction in guinea-pig pulmonary artery. Isometric tension of the isolated endothelium-denuded ring preparations was measured in the presence of indomethacin (10−5 mol/L) and NG-nitro-L-arginine methyl ester (l-NAME; 3X10−4 mol/L) to exclude a mechanism via endothelium, cyclo-oxygenase-generated eicosanoids and nitric oxide.2. In the additional presence of tetrodotoxin (TTX; 3X10−7 mol/L), ET-1 (10−11-10−7 mol/L) concentration-dependently contracted the preparations. The rank order of potency to contract the preparations among ET receptor agonists was ET-1, sarafotoxin (STX) 6b〉ET-3〉IRL 1620, STX 6c. BQ-123 (7X10−7-7X10−6 mol/L) concentration-dependently shifted the concentration-contraction curve for ET-1 to the right in a parallel manner. Pretreatment with STX 6c (3X10−7 mol/L for 30 min) did not significantly desensitize contractions to ET-1, ET-3 or IRL 1620 (P〉0.05; t-test, 10 d. f.).3. ET-1 (10−10-10−9 mol/L) and STX 6b (10−9-10−8 mol/L) significantly enhanced the electrical field stimulation-induced contraction in a BQ-123-sensitive manner (P〈0.05; t-test, 24–38 d.f.), while ET-3 (10−11-10−8 mol/L) and STX 6c (10−11-10−7 mol/L) did not affect contractions. ET-1 (10−11 mol/L) significantly enhanced contractions to exogenous nor-adrenaline in the presence of TTX (3X10−7 mol/L) (P〈0.05; t-test, 16 d.f.).4. These data indicate that the BQ-123-sensitive ETA receptor mediates both contraction and enhancement of adrenergic contractions in the guinea-pig pulmonary artery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1996.tb02745.x
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  • 3
    Electronic Resource
    Electronic Resource
    Gene cloning, purification, and characterization of thermostable and halophilic leucine dehydrogenase from a halophilic thermophile, Bacillus licheniformis TSN9 (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 432-438 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  A halophilic and thermophilic isolate from the sand of Tottori Dune was found to produce a thermostable and halophilic leucine dehydrogenase (EC 1.4.1.9). It was identified to be a new strain of Bacillus licheniformis. The enzyme gene was cloned into Escherichia coli JM109 with a vector plasmid pUC18. The enzyme was purified to homogeneity from the clone cell extract by ion-exchange column chromatography with a yield of 31%. The enzyme was found to be composed of eight subunits identical in relative molecular mass (43 000). The amino acid sequence of the enzyme, deduced from the nucleotide sequence of the gene, showed an identity of 84.6% with that of the B. stearothermophilus enzyme [Nagata S, Tanizawa K, Esaki N, Sakamoto Y, Ohshima T, Tanaka H, Soda K (1988) Biochemistry 27:9056–9062], although both enzymes were similar to each other in various enzymological properties such as thermostability, substrate and coenzyme specificities, and stereospecificity for hydrogen transfer from the C-4 of NADH. However, they were markedly distinct from each other in halophilicity: the B. licheniformis enzyme was much more stable than the other in the presence of high concentrations of salts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530050578
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  • 4
    Electronic Resource
    Electronic Resource
    Gene cloning, purification, and characterization of thermostable and halophilic leucine dehydrogenase from a halophilic thermophile, Bacillus licheniformis TSN9 (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 432-438 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A halophilic and thermophilic isolate from the sand of Tottori Dune was found to produce a thermostable and halophilic leucine dehydrogenase (EC 1.4.1.9). It was identified to be a new strain of Bacillus licheniformis. The enzyme gene was cloned into Escherichia coli JM109 with a vector plasmid pUC18. The enzyme was purified to homogeneity from the clone cell extract by ion-exchange column chromatography with a yield of 31%. The enzyme was found to be composed of eight subunits identical in relative molecular mass (43 000). The amino acid sequence of the enzyme, deduced from the nucleotide sequence of the gene, showed an identity of 84.6% with that of the B. stearothermphilus enzyme [Nagata S, Tanizawa K, Esaki N, Sakamoto Y, Ohshima T, Tanaka H, Soda K (1988) Biochemistry 27:9056–9062], although both enzymes were similar to each other in various enzymological properties such as thermostability, substrate and coenzyme specificities, and stereospecificity for hydrogen transfer from the C-4 of NADH. However, they were markedly distinct from each other in halophilicity: the B. licheniformis enzyme was much more stable than the other in the presence of high concentrations of salts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169940
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  • 5
    Electronic Resource
    Electronic Resource
    Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus (1999)
    Springer
    Diabetologia 42 (1999), S. 1332-1340 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Type I diabetes ; Fas ; Fas ligand ; insulitis ; human pancreas ; apoptosis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Type I (insulin-dependent) diabetes results mainly from T-cell-mediated autoimmune destruction of pancreatic beta cells. Cytotoxic T lymphocytes destroy target cells via a perforin-based or Fas-based mechanism. Our previous study indicated that the Fas-Fas ligand (FasL) pathway is required for the development of autoimmune diabetes in the NOD mouse. We now investigated whether or not the Fas-FasL system is involved in the beta-cell destruction in human Type I diabetes. Methods. We immunohistochemically analysed pancreas biopsy specimens of 13 recent-onset patients. Results. Pancreatic islets were identified but showed various degrees of reduction in beta-cell volume in all patients. Out of 13 patients 6 had insulitis. In these 6 patients Fas was expressed in both the islets and infiltrating cells but not in either cell type in the 7 other patients without insulitis. Double immunostaining showed that Fas was positive in 92.2 to 97.7 % of beta cells but only in 17.6 to 46.7 % of alpha cells in Fas-positive, insulin-remaining islets. We found FasL was expressed exclusively in islet-infiltrating cells in patients with insulitis. Double immunostaining revealed that the most prevalent phenotype of FasL-positive cells was CD8, which was followed by macrophages and CD4. Conclusion/interpretation. The interaction between Fas on beta cells and FasL on infiltrating cells might trigger selective apoptotic beta-cell death in inflamed islets, leading to immune-mediated Type I diabetes. [Diabetologia (1999) 42: 1332–1340]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051446
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  • 6
    Electronic Resource
    Electronic Resource
    Liberation of platelet histamine by the alkaline tissue extract and oleic acid (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 1329-1330 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Durch In-vitro-Inkubation mit alkalischen Gewebsextrakten oder mit Oleinsäure wurde Histamin aus den Blutplättchen von Kaninchen freigesetzt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113010
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  • 7
    Electronic Resource
    Electronic Resource
    TDS and RB Studies of Ar Implanted to Si (1995)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 196-201 (Nov. 1995), p. 1375-1380 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.196-201.1375.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Cholesterol granuloma in the middle cranial fossa: report of two cases (1995)
    Springer
    Neuroradiology 37 (1995), S. 564-567 
    Details
    ISSN: 1432-1920
    Keywords: Cholesterol granuloma ; Magnetic resonance imaging ; Middle cranial fossa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two cases of cholesterol granuloma in the middle cranial fossa. On CT the lesions appeared as a nonspecific, nonenhancing soft-tissue mass with bone erosion. On MRI they were seen as areas of high signal intensity surrounded by a low-intensity peripheral zone on both T1- and T2-weighted images. Cholesterol granuloma is thought to occur when pneumatised cellsin the temporal bone become obstructed. Although this lesion usually occurs in the petrous bone, it can extend to the middle cranial fossa. The diagnosis and surgical management are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593723
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  • 9
    Electronic Resource
    Electronic Resource
    Cholesterol granuloma in the middle cranial fossa: report of two cases (1995)
    Springer
    Neuroradiology 37 (1995), S. 564-567 
    Details
    ISSN: 1432-1920
    Keywords: Key words Cholesterol granuloma ; Magnetic resonance imaging ; Middle cranial fossa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two cases of cholesterol granuloma in the middle cranial fossa. On CT the lesions appeared as a nonspecific, nonenhancing soft-tissue mass with bone erosion. On MRI they were seen as areas of high signal intensity surrounded by a low-intensity peripheral zone on both T1- and T2-weighted images. Cholesterol granuloma is thought to occur when pneumatised cells in the temporal bone become obstructed. Although this lesion usually occurs in the petrous bone, it can extend to the middle cranial fossa. The diagnosis and surgical management are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593723
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  • 10
    Electronic Resource
    Electronic Resource
    Hyponatremia in central partial diabetes insipidus due to postoperative hypothalamic tumor (1995)
    Springer
    Child's nervous system 11 (1995), S. 712-714 
    Details
    ISSN: 1433-0350
    Keywords: Hyponatremia ; Central diabetes insipidus ; Osmoreceptor ; Arginine vasopressin ; Hypothalamic tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the case of a 4-year-old boy with a postoperative hypothalamic tumor, who exhibited unusual water and electrolyte disturbance. This developed as a late manifestation during the course of central diabetes insipidus (DI), which started when the patient was 2 years old. Clinically, hyponatremia and DI appeared alternatlely within 1 day. The hyponatremia (lowest value Na+ 115 mmol/l) was associated with afebrile convulsions. Assessment of fluid status revealed that the patient had a reduced capacity for arginine vasopressin (AVP) secretion (partial DI), which was not physiologically regulated and which was not concomitantly sufficient to produce maximally concentrated urine and allow the production of maximally diluted urine. This defective osmoreceptor function in association with the previously existing reduced capacity for AVP release seemed to be responsible for the fluid disturbance in the patient. The administration of nasal 1-desamino-8d-arginine vasopressin (DDAVP) only when urine output was increased, instead of regular administration at a fixed time, prevented both worsening of hyponatremia and development of DI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262237
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