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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 73 (1969), S. 4256-4263 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: OMEGA, a 60-beam, 351 nm, Nd:glass laser with an on-target energy capability of more than 40 kJ, is a flexible facility that can be used for both direct- and indirect-drive targets and is designed to ultimately achieve irradiation uniformity of 1% on direct-drive capsules with shaped laser pulses (dynamic range (approximately-greater-than)400:1). The OMEGA program for the next five years includes plasma physics experiments to investigate laser–matter interaction physics at temperatures, densities, and scale lengths approaching those of direct-drive capsules designed for the 1.8 MJ National Ignition Facility (NIF); experiments to characterize and mitigate the deleterious effects of hydrodynamic instabilities; and implosion experiments with capsules that are hydrodynamically equivalent to high-gain, direct-drive capsules. Details are presented of the OMEGA direct-drive experimental program and initial data from direct-drive implosion experiments that have achieved the highest thermonuclear yield (1014 DT neutrons) and yield efficiency (1% of scientific breakeven) ever attained in laser-fusion experiments. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We demonstrate a laser beam-smoothing technique known as polarization smoothing. A birefringent optical wedge splits the individual laser beams into two orthogonally polarized beams that, when coupled with a distributed phase plate, produce two speckle patterns shifted with respect to one another. This instantaneously reduces the on-target nonuniformity by a factor of (square root of 2). We measured this reduction optically and its effect is demonstrated in laser-driven targets. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 4885-4893 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Comparative electron polarization measurement with a helium electron polarimeter and a high-precision Mott detector are presented. For these measurements the helium electron polarimeter was calibrated according to theory, whereas the Mott detector was calibrated independently with an improved auxiliary-target method. The comparison of the experimental results reveals various problems inherent in helium electron polarimetry, such as poor efficiency and problems occurring in precise light polarization measurements. At present, a high-precision Mott detector is therefore clearly superior to a helium polarimeter with respect to efficiency and accuracy. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The upgrade to the OMEGA laser system, a 30-kJ, 351-nm, 60-beam direct-drive laser-fusion system is reported here. The system configuration is presented along with the status of its construction and the plans for system activation. The system utilizes rod and disk amplifiers and frequency tripling to produce UV pulses which are smoothed using phase conversion and smoothing by spectral dispersion. Dual driver lines will feed the propagation of two co-axial beams, which have different pulse widths and occupy different portions of the laser aperture. The laser system will be completed in November 1994 and the target area in March 1995. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Boston, MA, USA : Blackwell Science Inc
    The @breast journal 5 (1999), S. 0 
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: ▪ Abstract: The efficacy of mammographic screening for older women has not been well studied. The present study was designed to evaluate for downstaging of breast carcinomas associated with mammographic screening in older women. The study population consisted of 130 women age 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:1075122X:TBJ131:ges" location="ges.gif"/〉65 years with newly diagnosed breast carcinoma in 1993–1994 and was obtained from women enrolled in a large health maintenance organization. Mammographic screening, if done, was performed by a network of predominantly community-based radiologists. Significant downstaging was found for the breast cancers detected in women who had undergone mammographic screening compared to the breast cancers detected in women who had not undergone mammographic screening. The American Joint Committee on Cancer (AJCC) clinical stage was stage 0 and stage I in 7% (8/107) and 73% (78/107), respectively, of the breast cancers detected in women who had undergone mammographic screening compared to 0% (0/23) and 22% (5/23), respectively, of the breast cancers detected in women who had not undergone mammographic screening (p 〈 0.0001). Clinical Tis and T1 tumors were found in 7% (8/107) and 74% (79/107), respectively, of the breast cancers detected in women who had undergone mammographic screening compared to 0% (0/23) and 22% (5/23), respectively, of the breast cancers detected in women who had not undergone mammographic screening (p 〈 0.0001). Of the 102 AJCC clinical stage I–II breast cancers with known pathologic axillary lymph node staging, lymph node stage was N0 for 76% (66/87) of the women who had undergone mammographic screening compared to 53% (8/15) of the women who had not undergone mammographic screening (p = 0.019). The results of downstaging reported in this study are important because earlier staged lesions are associated with an improved prognosis and an increased potential for breast-conservation treatment. These findings have shown that mammographic screening is effective in downstaging breast carcinomas found in older women. ▪
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 19 (1999), S. 0 
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The Electric Power Research Institute (EPRI) has sponsored the development of a model to assess the long-term, overall “performance” of the candidate spent fuel and high-level radioactive waste (HLW) disposal facility at Yucca Mountain, Nevada. The model simulates the processes that lead to HLW container corrosion, HLW mobilization from the spent fuel, and transport by groundwater, and contaminated groundwater usage by future hypothetical individuals leading to radiation doses to those individuals. The model must incorporate a multitude of complex, coupled processes across a variety of technical disciplines. Furthermore, because of the very long time frames involved in the modeling effort (〉104 years), the relative lack of directly applicable data, and many uncertainties and variabilities in those data, a probabilistic approach to model development was necessary. The developers of the model chose a logic tree approach to represent uncertainties in both conceptual models and model parameter values. The developers felt the logic tree approach was the most appropriate. This paper discusses the value and use of logic trees applied to assessing the uncertainties in HLW disposal, the components of the model, and a few of the results of that model. The paper concludes with a comparison of logic trees and Monte Carlo approaches.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The nicotinic acetylcholine receptor (AChR) exhibits at least four different conformational states varying in affinity for agonists such as acetylcholine (ACh). Photoaffinity labeling has been previously used to elucidate the topography of the AChR. However, to date, the photosensitive probes used to explore the cholinergic binding site photolabeled only closed or desensitized states of the receptor. To identify the structural modifications occurring at the ACh binding site on allosteric transition associated with receptor activation, we have investigated novel photoactivatable 4-diazocyclohexa-2,5-dienone derivatives as putative cholinergic agonists. Such compounds are fairly stable in the dark and generate highly reactive carbenic species on irradiation. In binding experiments using AChRs from Torpedo marmorata, these ligands had affinities for the ACh binding site in the micromolar range and did not interact with the noncompetitive blocker site (greater than millimolar affinity). Irreversible photoinactivation of ACh binding sites was obtained with the ligand 1b (up to 42% at 500 µM) in a protectable manner. In patch-clamp studies, 1b was shown to be a functional agonist of peripheral AChR in TE 671 cells, with the interesting property of exhibiting no or very little desensitization even at high concentrations.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiac surgery 14 (1999), S. 0 
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Port-Access cardiac surgery is a recent technology that is undergoing rapid development. The learning curve associated with this technique is a challenge even for the skilled and experienced cardiac surgeon. Mainly because of femoral cannulation, the use of guidewires, and working through small incisions, Port-Access cardiac surgery contains certain pitfalls that are clearly associated with the technology involved. These pitfalls currently require troubleshooting, but as the technology progresses, this may become less of an issue. Communicating these pitfalls to others is important to help others to avoid or better manage complications and to contribute to improving the technology of Port-Access techniques.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ablation of VT in Tetralogy of Fallot. Introduction: Ventricular tachycardia is commonly seen in patients following surgical repair for tetralogy of Fallot. The technique of ablation for this arrhythmia is not well defined. Methods and Results: In two patients with ventricular tachycardia following surgical repair of tetralogy of Fallot, the traditional indicators for a site for ventricular tachycardia ablation did not yield cure. Based on careful mapping, the circuit was found to involve the isthmus between the outflow tract patch and the tricuspid annulus; linear radiofrequency lesions across this isthmus resulted in cure of ventricular tachycardia. Not only was the tachycardia no longer inducible, but bidirectional block at the line of ablation confirmed interruption of the reentrant circuit. Conclusion: A linear radiofrequency lesion was effective in eliminating ventricular tachycardia in both patients. The demonstration of bidirectional block confirms a cure independent of inducibility of ventricular tachycardia.
    Type of Medium: Electronic Resource
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