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Acute and anticipatory emesis in breast cancer patients (1996)

Fernández-Marcos, A. ; Martín, M. ; Rodriguez-Lescure, A. ; [et al.]

Springer

Supportive care in cancer 4 (1996), S. 370-377

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ISSN: 1433-7339

Keywords: Prevalence Anticipatory emesis ; Acute emesis ; Chemotherapy Ondansetron

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract A group of 90 breast cancer patients undergoing chemotherapy were assessed prospectively to estimate the prevalence of acute (post-treatment) and anticipatory emesis in the 1990s. For this purpose, two protocols of chemotherapy were analysed separately: cyclophosphamide/methotrexate/5-fluorouracil (CMF) and 5-fluorouracil/doxorubicin/cyclophosphamide (FAC). All patients were treated with antiemetic therapy, which included one corticoid plus ondansetron (in the FAC regimen), or one corticoid plus thiethylperazine (in the CMF regimen). For at least one cycle of chemotherapy 86.1% and 91.7% patients in the FAC protocol presented vomiting and nausea respectively; 11.1% had anticipatory vomiting and 30.6% had anticipatory nausea. In the CMF protocol, 79.6% had post-chemotherapy vomiting and 71.7% had post-chemotherapy nausea associated with at least one cycle. In this group, 7.4% had anticipatory vomiting and 16.6% had anticipatory nausea. A high proportion of patients suffered anticipatory anxiety in both groups (75% in FAC, 74.1% in CMF). The stimuli most frequently associated with the appearance of anticipatory emesis were olfactory stimuli and cognitive stimuli. In summary, as a result of the advances made in antiemetic control during the last decade, the severity of chemotherapy-induced emesis seems to have significantly decreased, but the prevalence of these symptoms along the course of the treatment still remains high.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01788844

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Non-equivalence Magnetique en Resonance Nucleaire - IV. Influence de Plusieurs Types de Dissymetries sur les Deplacements Chimiques et les Couplages Relatifs a des Systemes —O—CH2—CH3 et —S—CH2—CH3 (1969)

Martin, Mme Maryvonne L. ; Lefevre, M. François ; Lapeyre, Mme Denise ; [et al.]

Chichester : Wiley-Blackwell

Organic Magnetic Resonance 1 (1969), S. 19-26

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ISSN: 0030-4921

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: Magnetic non-equivalence of methylenic protons in A—CH2—CH3 groups were studied for several types of compounds. Results are compared with respect (1) to the nature of heteroatom A:A = O and A = S and (2) to the structure of the local dissymmetry element: asymmetric carbon, ketal group and allenic system. Influence of substitution is discussed in relation to conformational problems. Furthermore a variation of the methylene geminal coupling constant with substituents of carbon α to OEt is observed.

Notes: La non-équivalence magnétique des protons méthyléniques de groupements A—CH2—CH3 est étudiée dans plusieurs séries de composés. Les effets sont comparés d'une part dans les séries A = O et A = S, d'autre part dans les composés présentant un carbone asymétrique, un carbone de type cétal ou une dissymétrie allénique. L'influence de la substitution sur le carbone en α de AEt est discutée en relation avec les conformations. Une variation de la constante de couplage entre les protons méthyléniques géminés en function de la nature des substituants lointains est mise en évidence.

Additional Material: 6 Tab.