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  • 1995-1999  (4)
  • 1960-1964
  • 1950-1954
  • Malaria  (2)
  • Bamboo mosaic potexvirus  (1)
  • East/Japan Sea
  • 1
    Digitale Medien
    Digitale Medien
    Paracetamol disposition in Thai patients during and after treatment of falciparum malaria (1995)
    Springer
    European journal of clinical pharmacology 48 (1995), S. 65-69 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Paracetamol ; Malaria ; pharmacokinetics ; phase II conjugation ; glucuronidation ; sulphation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria. We have measured plasma concentrations and the urinary excretion of paracetamol and its phase II metabolites in eight Thai patients during uncomplicated falciparum malaria and in convalescence, following a 1000 mg single oral dose. The apparent oral clearance (Malaria, 3.6; Convalescence, 3.9; ml·min−1·kg−1), the elimination half-life (Malaria, 3.8; Convalescence, 3.7 h) and apparent volume of distribution (Malaria, 1.2; Convalescence, 1.2; l·kg−1) of paracetamol were similar during malaria and convalescence. In addition, the urinary excretion of paracetamol and its major phase II metabolites and their formation clearances from paracetamol were not significantly different between the two study phases. These data show that clinical malaria infection has no effect on the conjugation of paracetamol in man.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00202175
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of quinine in patients with chronic renal failure (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 497-501 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Quinine ; Malaria ; pharmacokinetics ; chronic renal failure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract Methods: We investigated the pharmacokinetics of quinine (Qn) following administration of a single oral dose of 600 mg Qn sulphate in six male Thai patients with a moderate degree of chronic renal failure (CRF), and six male Thai subjects with normal renal function. Results: The drug was well tolerated in both groups of subjects; no major adverse reactions were observed. A marked alteration in the pharmacokinetics of Qn was found in patients with CRF compared to healthy subjects; there were six signifiicant changes in the pharmacokinetic parameters. Absorption was delayed, but increased in CRF (tmax 4.5 vs 1.6 h, Cmax 6.17 vs 3.45 μg·ml−1). Total clearance was significantly reduced 0.94 vs 2.84 ml·min−1·kg−1, whereas Vz/f remained unchanged (1.82 vs 2.78 1·kg−1). This resulted in the increased values of AUC and prolongation of the t1/2z and MRT in the patients (AUC 181.5 vs 61.8 μg·min−1·ml−1, t1/2z 26 vs 9.7 h, MRT 36.4 vs 11.3 h). Median concentrations of plasma unbound fraction of Qn collected at 4 h after drug administration in patients and healthy subjects were 7.3 vs 9.8%, respectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00195937
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  • 3
    Digitale Medien
    Digitale Medien
    Annual and Seasonal Variations of the Sea Surface Heat Fluxes in the East Asian Marginal Seas (1999)
    Springer
    Journal of oceanography 55 (1999), S. 257-270 
    Details
    ISSN: 1573-868X
    Schlagwort(e): Surface heat flux ; net heat flux ; Yellow Sea ; East/Japan Sea ; East China Sea ; monthly and annual means
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie
    Notizen: Abstract Based on the twice-daily marine atmospheric variables which were derived mostly from the weather maps for 18 years period from 1978 to 1995, the surface heat flux over the East Asian marginal seas was calculated at 0.5°×0.5° grid points twice a day. The annual mean distribution of the net heat flux shows that the maximum heat loss occurs in the central part of the Yellow Sea, along the Kuroshio axis and along the west coast of the northern Japanese islands. The area off Vladivostok turned out to be a heat-losing region, however, on the average, the amount of heat loss is minimum over the study area and the estuary of the Yangtze River also appears as a region of the minimum heat loss. The seasonal variations of heat flux show that the period of heat gain is longest in the Yellow Sea, and the maximum heat gain occurs in June. The maximum heat loss occurs in January over the study area, except the Yellow Sea where the heat loss is maximum in December. The annual mean value of the net heat flux in the East/Japan Sea is −108 W/m2 which is about twice the value of Hirose et al. (1996) or about 30% higher than Kato and Asai (1983). For the Yellow Sea, it is about −89 W/m2 and it becomes −75 W/m2 in the East China Sea. This increase in values of the net heat flux comes mostly from the turbulent fluxes which are strongly dependent on the wind speed, which fluctuates largely during the winter season.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1007891608585
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  • 4
    Digitale Medien
    Digitale Medien
    A Defective RNA Associated with Bamboo Mosaic Virus and the Possible Common Mechanisms for RNA Recombination in Potexviruses (1999)
    Springer
    Virus genes 18 (1999), S. 121-128 
    Details
    ISSN: 1572-994X
    Schlagwort(e): Bamboo mosaic potexvirus ; defective RNA ; RNA combination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A naturally occurring 1.1 kb RNA was isolated from purified virions of bamboo mosaic potexvirus isolate S (BaMV-S). This RNA is a defective RNA (D RNA) derived from a single internal deletion of the BaMV genome. A cDNA clone representing the complete nucleotide sequence of the BaMV-S D RNA was generated and its nucleotide sequence was determined. The BaMV D cDNA is 1015 nts in length [excluding the poly(A) tail] and consists of two regions corresponding to 867 nts of the 5′ terminus and 148 nts of the 3′ terminus of the BaMV genomic RNA. BaMV D cDNA contains a single open reading frame (ORF) encoding a putative 29.7 kDa protein comprised of a fusion of the first 258 amino acids of BaMV ORF 1 and the last 2 amino acids of coat protein. The coding capacity of D RNA was verified by in vitro translation of native BaMV-S D RNA and of 1.1 kb RNA transcribed in vitro from the full-length D cDNA. BaMV D RNA can be reproducibly generated by serial passages of BaMV-S in Nicotiana benthamiana and is the first D RNA in the potexvirus group shown to be generated de novo. Alignments of sequences surrounding the 5′ and 3′ junction borders of reported potexvirus D RNAs reveal a 65.2–84.6% sequence identity, suggesting that common mechanisms for viral RNA recombination are involved in the generation of potexvirus D RNAs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008008400653
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