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  • 11
    Electronic Resource
    Electronic Resource
    Bone mineral density of the proximal femur after unilateral cementless total hip replacement (1999)
    Springer
    International orthopaedics 23 (1999), S. 104-106 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé  Le but de cette étude est de déterminer prospectivement la densité osseuse préopératoire et de la comparer avec les résultats de la densité postopératoire après l’implantation d’une prothése de hanche controlaterale. La densité osseuse de 45 malades (x=54 années) a été mesurée avec la méthode DEXA à la hanche non operée, une semaine, 3 et 6 mois après l’implantation d’une prothese. Nos résultats montrent une réduction de la densité osseuse par l’immobilisation entre −3 et −5,9% (x=−3,9%). Cette différence diminue dans les prochains trois mois à une valeur de −2.5%, qui n’etait plus significative. L’évaluation préopérative montrait une différence de −4.5% en faveur de la hanche qui n’était pas atteinte (12 hanches).
    Notes: Abstract  It was the aim of this study to examine bone mineral density changes in the non-operated contralateral femur of patients undergoing total hip replacement. Bone density in the contralateral femur of 45 patients with an average age of 54 years was measured with the aid of the DEXA technique at one week, 3 and 6 months after total hip replacement. Within the first 3 months there was an average reduction of bone density of 3.9% (3.0%–5.9%). After a further 3 months the average difference was 2.5%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050318
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  • 12
    Electronic Resource
    Electronic Resource
    Determination of periprosthetic bone density with the DEXA method after implantation of custom-made uncemented femoral stems (1996)
    Springer
    International orthopaedics 20 (1996), S. 218-221 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. L’implantation d’une prothèse de la hanche a pour conséquence une diminution de la densité osseuse du fémur autour de la prothèse. Selon la littérature ce procéssus dépend surtout de la forme de la prothèse et de la durée de l’implantation. La densité osseuse de 27 malades a été mésurée avec la méthode DEXA en moyenne 21 mois après l’implantation d’une prothèse sur mesure de la hanche. Nos résultats montrent une réduction de la densité osseuse entre 5 (ROI 1) et 21% (ROI 7), surtout au calcar proximal. La réduction de la densité osseuse ne dépendait pas de la durée de l’implantation. En comparaison avec la littérature ces résultats, surtout la diminution très restreinte au ROI 7, sont en faveur d’une forme individuelle d’une prothèse de la hanche.
    Notes: Summary. Implantation of a total hip replacement leads to resorption of bone, especially in the upper femoral shaft and this depends mainly on the design of the stem, and also on the survival time of the implant. Density of the periprosthetic bone was examined with the DEXA method in both femurs in 27 patients at a mean of 21 months after implantation of uncemented custom-made femoral stems. A loss of bone density between 5% and 21% was found which was independent of the survival time of the implant. The maximum decrease was at the upper medial part of the calcar. The negligible loss of bone density, compared to other reports, favours the use of a computer tomography assisted custom-made femoral stem.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050067
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  • 13
    Electronic Resource
    Electronic Resource
    Developmental control of transcription of the cat reporter gene by a truncated mouse alphafetoprotein gene regulatory region in transgenic mice (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 42 (1995), S. 1-6 
    Details
    ISSN: 1040-452X
    Keywords: Alphafetoprotein ; Liver gene expression ; Promoter/enhancer regions ; Transgenic mice ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: A truncated mouse alphafetoprotein (AFP) gene promoter/enhancer region was tested for its ability to regulate the expression of the Escherichia coli chloramphenicol acetyltransferase (CAT) reporter gene in the livers of transgenic mice. The AFP regulatory region lacked any AFP gene structural DNA, included one enhancer sequence together with the proximal promoter sequence, and an element believed to be responsible for the postnatal repression of AFP gene transcription. The neonatal livers of AFP/CAT transgenic mice showed a high level of CAT enzyme expression, which was dramatically reduced between 7 and 14 days after birth. The staining of liver sections with anti-CAT antibodies showed that this expression was limited to hepatocytes. In one lineage, reexpression of CAT in the adult liver could be achieved by restitutive proliferation of hepatocytes following partial hepatectomy or CCl4-induced necrosis; reexpression in young animals (3-4 weeks of age) was even greater. These studies show that a truncated AFP promoter/enhancer region functions in a tissue-specific and developmental stage-specific fashion, and may be used to control the expression of other genes in the livers of transgenic mice. © 1995 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080420102
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