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  • 1
    Electronic Resource
    Electronic Resource
    Endothelial function and nitric oxide production in rats adapted to intermittent hypoxia (1995)
    Springer
    Bulletin of experimental biology and medicine 120 (1995), S. 1117-1120 
    Details
    ISSN: 1573-8221
    Keywords: adaptation to hypoxia ; nitric oxide ; endothelial relaxation factor ; endothelium-dependent relaxation ; tail artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Adaptation to intermittent hypoxic hypoxia did not affect the endothelium-dependent relaxation of the aorta in rats, but significantly increased the relaxation of their tail artery. Following the adaptation, the NO level fell in the liver, intestine, and kidneys and remained unchanged in the spleen. Adaptation to hypoxia presumably limits NO synthesis and/or release in the vascular endothelium or enhances the capacity of this oxide to bind in a physiologically active depot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02445480
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  • 2
    Electronic Resource
    Electronic Resource
    Opposite effect of adaptation to physical exercise on myocardium and skeletal muscle. Ca-transporting system of the sarcoplasmic reticulum and antioxidant defense enzymes (1996)
    Springer
    Bulletin of experimental biology and medicine 121 (1996), S. 561-565 
    Details
    ISSN: 1573-8221
    Keywords: adaptation to physical exercise ; Ca transport ; sarcoplasmic reticulum ; myocardium ; skeletal muscle ; catalase ; superoxide dismutase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Adaptation to physical exercise was achieved via 60-min sessions of swimming at 32°C for 45 days, the duration of swimming being increased from 15 to 60 min during the first 14 days. Under these conditions, against the background of reduced catalase and superoxide dismutase activity the Ca-transporting system of the sarcoplasmic reticulum in the heart is shown to work more effectively: Ca2+ transport is characterized by a higher initial rate and is inactivated 1.5 times more slowly byin vitro-induced lipid peroxidation and not inhibited by high concentrations of free Ca2+. In the skeletal muscle, on the other hand, catalase and superoxide dismutase activity rise, but this does not improve the functioning of the Ca pump: the initial rate of Ca2+ transport drops, its resistance to autooxidation is not increased in comparison with the control, and the resistance of the Ca2+-transporting system to the inhibiting influence of free Ca2+ is lowered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447117
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  • 3
    Electronic Resource
    Electronic Resource
    The myocardium and hemodynamics in cardiac hyperfunction and insufficiency (1963)
    Springer
    Bulletin of experimental biology and medicine 54 (1963), S. 1092-1096 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In cases withvitium cordis only a part of work done by the ventricle is transformed into its external work. All the work performed by the ventricle may be designated as total work, whereas the ratio of external and total work is designated as mechanical efficiency of the ventricle. The study of the dynamics of external, total work and of the mechanical efficiency of the left ventricle in the process of progressive aortic stenosis development demonstrated that in the given experimental vitium cordis the energy losses for overcoming the blood flow resistance in the area of stenosis lead to a 4-fold reduction in the mechanical efficiency of the left ventricle (as compared to the normal). Suggestions are presented on determination of total work and of mechanical efficiency in other forms of vitium cordis; it is also suggested that reduction of the efficiency of the heart in cardiac insufficiency depends not only on disturbed myocardial metabolism, but also on the drop of mechanical efficiency of the heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00784603
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in the intramural nervous apparatus in compensatory cardiac hypertrophy (1962)
    Springer
    Bulletin of experimental biology and medicine 52 (1962), S. 1213-1216 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Changes in the intramural nerve ganglia and in the myocardium caused by experimentally induced compensatory cardiac hyperfunction followed a definite pattern. During the first stage there was an edema of the neurones, various stages of diffuse lysis of the Nissl substance, and vacuolization of the processes of the nerve cell. The second stage was one of relatively stable hyperfunction, during which the edema disappeared from most of the neurones. A small proportion of the neurones were irreversibly damaged, and died.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00787290
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  • 5
    Electronic Resource
    Electronic Resource
    Changes in the intensity of protein synthesis in the myocardium during compensatory hyperfunction of the heart (1961)
    Springer
    Bulletin of experimental biology and medicine 50 (1961), S. 678-680 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Compensatory hyperfunction of the heart in vitium cordis, hypertension and other diseases of the circulatory system connected with the cardiac overstrain of long duration represents the main factor in preservation of normal hemodynamic indices and clinical compensation. The rate of protein synthesis in the myocardium was studied under conditions of compensatory cardiac hyperfunction provoked by experimentally induced vitium cordis. As established, rapid development of hypertrophy during the first emergency stage of compensatory hyperfunction is accompanied by an intensified rate of protein synthesis (it about doubles). In the second stage of relatively stable hyperfunction the rate of protein synthesis is normal, while at the third stage — characterized by cardiosclerosis and progressive exhaustion —it is reduced 2–2.5 times. This depression of the normal renovation process of the protein myocardial structures may bring about a change in the contractile proteins of the heart, thus playing an important role in the development of cardiosclerosis and cardiac insufficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00796034
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  • 6
    Electronic Resource
    Electronic Resource
    The myocardium and the hemodynamics during cardiac hyperfunction and insufficiency. Report 2. Lowering of the resistance of the vascular field as an economic compensatory factor in diseases of the circulatory system (1964)
    Springer
    Bulletin of experimental biology and medicine 55 (1964), S. 26-29 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary During gradual reproduction of experimental aortic stenosis in dogs there occurs a considerable reduction of the general vascular resistance. This shift is clearly observed not only in stenosis of the aorta, it is an important compensatory factor maintaining the normal cardiac output in economic use of the myocardial reserves. A drop in vascular resistance during intensive cardiac hyperfunction may be due to the reflux from the receptors of the left ventricle to the arteriolar musculature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00800194
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  • 7
    Electronic Resource
    Electronic Resource
    Increased resistance to heat shock of isolated hearts from rats adapted to moderate physical exercise (1995)
    Springer
    Bulletin of experimental biology and medicine 119 (1995), S. 245-247 
    Details
    ISSN: 1573-8221
    Keywords: adaptation to physical exercise ; isolated heart ; heat shock ; resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Hearts isolated from rats adapted to physical activity through moderate regular exercise (swimming) were more resistant to heat shock than hearts from unadapted controls. Thus, 15-min perfusion of control hearts with a solution heated to 42°C significantly depressed contraction amplitudes and caused a contracture amounting to 36% of the initial contraction amplitude, as well as increased release of creatine kinase into the perfusate. In the hearts from adapted rats, contraction amplitude was, on average, 2.3-fold greater and the contracture 3.2 times less marked than in the control animals; the test and control hearts did not differ significantly in the release of creatine kinase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02445826
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  • 8
    Electronic Resource
    Electronic Resource
    Adaptation to periodic hypoxia and a diet supplemented with polyunsaturated class ω-3 fatty acids enhance the resistance of Ca2+ transport in the myocardial sarcoplasmic reticulum to free-radical oxidation (1995)
    Springer
    Bulletin of experimental biology and medicine 120 (1995), S. 687-690 
    Details
    ISSN: 1573-8221
    Keywords: polyunsaturated fatty acids ; adaptation ; lipid peroxidation ; Ca 2+ transport ; myocardium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The relationship between the level of accumulation of lipid peroxidation products and the status of the Ca2+-transporting system in the sarcoplasmic reticulum of the rat myocardium is studied against the background of two cardioprotective factors, namely adaptation to periodic hypoxia and a diet enriched in polyunsaturated fatty acids of the ω-3 class. It is shown that the diet leads to an increase of level of lipid peroxidation products by 1.8 times in the heart and by 19 times in the liver, whereas a adaptation has no effect on the level of lipid peroxidation products in either of these organs. At the same time, the combined action of both factors considerably enhances the resistance of the myocardial Ca2+-transporting system to free radical-induced oxidation. Inin vitro experiments it is shown that adaptation to periodic hypoxia results in a more than twofold deceleration of Ca2+ transport inhibition during the oxidation induction by the Fe2+/ascorbate system; the diet causes a 3.5-fold deceleration of such inhibition. The results show that the accumulation of a high level of lipid peroxidation products is not always followed by damage to the Ca2+-transporting system in the myocardial sarcoplasmic reticulum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02444661
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  • 9
    Electronic Resource
    Electronic Resource
    Seasonal differences in the development of heightened resistance of the isolated heart during adaptation to physical exercise (1995)
    Springer
    Bulletin of experimental biology and medicine 120 (1995), S. 938-940 
    Details
    ISSN: 1573-8221
    Keywords: adaptation to physical exercise ; heart ; ischemia ; reperfusion ; seasonal differences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Substantial seasonal differences are found in the development of the cardioprotective effect of adaptation to physical exercise: in winter such adaptation results in an increase of the resistance of the isolated heart to the contracture and arrhythmogenic effects of ischemia and reperfusion, while in summer the anticontracture effect is absent and the antiarrythmic effect is significantly lowered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02445022
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  • 10
    Electronic Resource
    Electronic Resource
    Increased effect of extrarenal pressor factors following removal of kidneys (1961)
    Springer
    Bulletin of experimental biology and medicine 50 (1961), S. 913-916 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Experiments on rabbits have shown that the pressor effect of adrenalin and pituitrin increases considerably 48 hours after removal of both kidneys. This result confirms the authors' opinion that hypertension due to nephrectomy may be caused by an increased effect of extrarenal pressor factors without any change in their amount.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00797478
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