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  • 1
    Electronic Resource
    Electronic Resource
    A common mitochondrial DNA variant is associated with insulin resistance in adult life (1998)
    Springer
    Diabetologia 41 (1998), S. 54-58 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin resistance ; mitochondrial DNA ; mitochondrial diabetes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mitochondrial DNA is maternally inherited. Mitochondrial DNA mutations could contribute to the excess of maternal over paternal inheritance of non-insulin-dependent diabetes mellitus (NIDDM). We therefore investigated the relationship between this variant, insulin resistance and other risk factors in a cohort which had been well characterised with respect to diabetes. Blood DNA was screened from 251 men born in Hertfordshire 1920–1930 in whom an earlier cohort study had shown that glucose tolerance was inversely related to birthweight. The 16 189 variant (T- 〉 C transition) in the first hypervariable region of mitochondrial DNA was detected using the polymerase chain reaction and restriction digestion. DNA analysis showed that 28 of the 251 men (11 %) had the 16 189 variant. The prevalence of the 16 189 variant increased progressively with fasting insulin concentration (p 〈 0.01). The association was independent of age and body mass index and was present after exclusion of the patients with NIDDM or impaired glucose tolerance. We found that insulin resistance in adult life was associated with the 16 189 variant. This study provides the first evidence that a frequent mitochondrial variant may contribute to the phenotype in patients with a common multifactorial disorder. [Diabetologia (1998) 41: 54–58]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050866
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A Nod factor-binding lectin is a member of a distinct class of apyrases that may be unique to the legumes (1999)
    Springer
    Molecular genetics and genomics 262 (1999), S. 261-267 
    Details
    ISSN: 1617-4623
    Keywords: Key words Nod factor binding ; Lectin ; Apyrase ; Legume
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Recent studies from our laboratory have found that a root lectin from the legume Dolichos biflorus is present on the root surface, binds rhizobial Nod factor and has apyrase activity. To assess the broader significance of this lectin/nucleotide phosphohydrolase (Db-LNP), we have cloned a second related cDNA (Db-apyrase-2) from D. biflorus, as well as related cDNAs from the legumes Lotus japonicus and Medicago sativa, and from Arabidopsis thaliana, a non-legume. The deduced amino acid sequences of these apyrases were aligned with one another and with the sequences of other apyrases from plants, animals, yeast and protozoa. Phylogenetic analysis shows that Db-LNP has closely related orthologs only in other legumes, while Db-apyrase-2 is more closely related to apyrase sequences from non-leguminous plants. We also show that the orthologs of Db-LNP from M. sativa and Pisum sativum have carbohydrate binding activity. The results suggest that legume LNPs may represent a special class of apyrases that arose by gene duplication and subsequent specialization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380051082
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    Paper (German National Licenses)
    Fulltext
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