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  • 1995-1999  (2)
  • 1955-1959
  • Blood coagulation disorders  (1)
  • Key wordsNitric oxide synthase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 351 (1995), S. 453-463 
    ISSN: 1432-1912
    Keywords: Key wordsNitric oxide synthase ; Tetrahydrobiopterin ; Pteridine metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (6R)-5,6,7,8-Tetrahydro-L-biopterin (H4biopterin) is well known as a cofactor of enzymes that hydroxylate aromatic amino acids. More recent work has revealed an essential role of H4biopterin in the biosynthesis of nitric oxide (NO), an intercellular messenger molecule synthesized from L-arginine by different NO synthase isozymes in many species and tissues. While the function of H4biopterin in aromatic amino acid hydroxylation is well established, the role of this pteridine in NO synthesis is, as yet, elusive. Current experimental evidence hints at a dual mode of action of H4biopterin, involving both an allosteric effect on the NO synthase protein and participation as a reactant in L-arginine oxidation. As discussed in detail in the present article, the latter effect of this pteridine may be related to the protection of NO synthase from feedback inhibition by NO.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-3932
    Keywords: Schlüsselwörter Blutungsneigung ; Hämorrhagische Diathese ; Erworbene und angeborene Thrombopathien ; Plasmatische Gerinnungstörungen ; DDAVP ; Key words Bleeding tendency ; Hemorrhagic diathesis ; Acquired and congenital qualitative platelet disorders ; Blood coagulation disorders ; Deamino-d-arginine vasopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract In surgical procedures associated with high blood loss, such as vascular and cardiac operations, differential diagnosis and therapy of perioperative hemorrhage are of special importance. Preoperative screening for patients at high risk of bleeding and in particular for those with qualitative platelet disorders [drug-induced platelet disorders (in particular ASS), von Willebrand's disease and other congenital platelet disorders] is effective in minimizing blood loss. Bleeding in acute medical emergencies or during emergency operations may require treatment without specific investigations being performed in advance. Therefore, simple schemes are essential for the rapid management of acute hemostatic problems. The aim of this paper was to address the diagnostic and therapy of hemorrhagic diathesis focusing mainly on diagnosis and therapy of hemorrhagic diathesis due to blood platelet disorders and blood coagulation disorders and preoperative identification of patients at increased risk of bleeding.
    Notes: Zusammenfassung Die Differentialdiagnostik und Therapie von perioperativen Blutungen besitzt in der Gefäß- und Kardiochirurgie bei Eingriffen mit hohen Blutverlusten einen besonderen Stellenwert. So ist es sinnvoll, Patienten mit einem erhöhten Blutungsrisiko bereits präoperativ zu erfassen und adäquat vorzubereiten. Insbesondere die präoperative Erfassung von Thrombopathien [medikamenteninduzierte Thrombopathien (insbesondere durch ASS), von-Willebrand-Jürgens-Syndrom, andere angeborene Thrombopathien] ist bei der Minimierung von Blutverlusten effektiv. Nicht elektive Situationen (Blutung bei Notoperationen, Akutpatienten) müssen oft ohne gezielte hämostaseologische Diagnostik rational therapiert werden. Einfache Schemata sind für ein schnelles Handeln unabdingbar. In dieser Arbeit soll versucht werden, Hinweise zu Diagnostik und Therapie der hämorrhagischen Diathese mit den Schwerpunkten: Diagnostik und Therapie der thrombozytär bedingten hämorrhagischen Diathese und Diagnostik und Therapie der plasmatisch bedingten hämorrhagischen Diathese aus hämostaseologisch-transfusionsmedizinischer Sicht zu vermitteln. Ein für den Routinebetrieb auf chirurgischen Stationen anwendbares Schema zur präoperativen Erfassung von Patienten mit erhöhtem Blutungsrisiko sowie erste Erfahrungen damit werden vorgestellt.
    Type of Medium: Electronic Resource
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