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  • 1
    Electronic Resource
    Electronic Resource
    Epidermal melanocytes in normal and tyrosinase-negative oculocutaneous albinism fetuses (1995)
    Springer
    Archives of dermatological research 287 (1995), S. 529-533 
    Details
    ISSN: 1432-069X
    Keywords: Melanocytes ; Fetuses ; Tyrosinase-negative oculocutaneous albinism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In tyrosinase-negative (type IA) oculocutaneous albinism (tyr(-) OCA) fetuses the development of melanocytes has not been fully elucidated. We analysed the distribution of melanocytes in skin samples from a fetus with tyr(-) OCA and from four normal fetuses. Skin samples obtained from 12 different body sites of each fetus were examined by transmission electron microscopy, an electron microscopic DOPA reaction test and immunohistochemistry. No S100 protein-positive cells were detected in any sample. There were fewer HMB-45-positive melanocytes in the skin of the tyr(-) OCA fetus than in the skin of normal fetuses from all body sites sampled. The greatest number of HMB-45-positive melanocytes was present in samples from the scalp of the normal fetuses and in those from the lower limbs of the tyr(-) OCA fetus. Very few melanocytes were detected immunohistochemically in samples from the soles and palms, though their presence was confirmed by transmission electron microscopy. The electron microscopic DOPA reaction test enhanced the melanization of melanocytes in samples from the normal fetuses but not in those from the tyr(-) OCA fetus. Postembedding immunogold electron microscopy using the HMB-45 antibody revealed that the HMB-45 antigen was localized mainly on stages I and II melanosomes. The presence of epidermal melanocytes in samples from all fetal body areas obtained at 17–21 weeks of gestation justifies the use of the electron microscopic DOPA reaction test in the prenatal diagnosis of tyr(-) OCA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374071
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  • 2
    Electronic Resource
    Electronic Resource
    Metallothionein content increased in the liver of mice exposed to magnetic fields (1996)
    Springer
    Archives of toxicology 70 (1996), S. 315-318 
    Details
    ISSN: 1432-0738
    Keywords: Key words Metallothionein ; Static magnetic fields ; Carbon tetrachloride ; Liver ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Although recent studies have shown that various stress can induce metallothionein (MT) synthesis in animal tissues, the induction of MT synthesis by exposure to static magnetic fields (SMF) has not been reported. We measured MT levels in the liver, kidney and brain of mice exposed to SMF and also evaluated the effect of SMF exposure on the induction of hepatic MT by treatment with carbon tetrachloride (CCl4). The MT content in the liver was significantly increased by exposure to 4.7 T of SMF for 6, 24, or 48 h, whereas that in the kidney or brain was not changed compared to the control. The combination of CCl4 injection and SMF exposure induced elevation of the hepatic MT content exceeding that induced by either treatment alone. These results indicate that exposure to the strong SMF induces MT synthesis in the liver in mice and enhances the hepatic MT synthesis induced by CCl4 administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050280
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    Paper (German National Licenses)
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