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  • 1
    Electronic Resource
    Electronic Resource
    Euthanasia: a personal experience in gynecologic oncology (1995)
    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 5 (1995), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Euthanasia means the active causation of death by a life-shortening medical act performed on a seriously ill patient who has a concrete expectation to die. The request for euthanasia has always existed. In medical ethics the value of the protection of human life and the value of respect for the desire to die in dignity are both standards of equal order. In the process of euthanasia the wish of the patient is the most important. It is the responsibility of the doctor in attendance to keep all the personnel involved very well informed about the wishes of the patient, to prevent difficulties in the process of decision making. One has to realize that the emotional burden assumed by the doctor and nurses is very important. They become involved in the process of taking leave but have to give priority to their task as caregivers. Euthanasia can take place only as a part of terminal care which is given with much effort and personal concern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1995.05010071.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanisms of Neural Patterning and Specification in the Development Cerebellum (1995)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 18 (1995), S. 385-408 
    Details
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ne.18.030195.002125
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  • 3
    Electronic Resource
    Electronic Resource
    An education programme promoting organ donation for 13–14 year old schoolchildren (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 1 (1995), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: Many programmes have attempted community education in organ donation. Too often these ‘preach to the converted’ or concentrate on special interest groups, thus failing to widely influence community perceptions of transplantation and organ donation.As 13–14 year old children appear sufficiently mature to be receptive to challenging ideas yet may not yet have developed fixed biases or opinions to impair concept assimilation, an educational package dealing with dialysis/transplantation and organ donation was tested in two evenly aged, socio-economic and sex matched student groups at this age level in a single co-educational school. One group only was exposed to a 3 h comprehensive course in renal structure and function, dialysis and transplantation. the two groups were assessed 1 year later by questionnaire to test the retention of information and, more importantly, to compare attitudes to organ donation.Statistically significant differences characterized the knowledge of and attitudes towards dialysis and transplantation between the two groups. In particular, the tutored group was much more likely to agree to organ donation by self (P〈0.009) or by relatives (P〈0.03) when compared to the untutored group.This study demonstrates that a short, simple education course for 13–14 year old students can favourably change their perceptions and attitudes towards organ donation. the wider application of similar courses may have a positive impact upon dialysis and transplantation awareness and, ultimately, on national donor rates, becoming a useful addition to national strategies to increase organ donation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.1995.tb00022.x
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  • 4
    Electronic Resource
    Electronic Resource
    BAC-mediated gene-dosage analysis reveals a role for Zipro1 ( Ru49 / Zfp38 ) in progenitor cell proliferation in cerebellum and skin (1999)
    [s.l.] : Nature America Inc.
    Nature genetics 22 (1999), S. 327-335 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Genetic analysis in mice has most commonly employed two general strategies: phenotypic screens for spontaneous or induced mutations and genotypic analysis using homologous recombination or gene trapping to produce deletion or insertion mutants. Here we use bacterial artificial chromosome ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/11896
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  • 5
    Electronic Resource
    Electronic Resource
    Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome (1997)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 15 (1997), S. 859-865 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Escherichia coli-based artificial chromosomes have become important tools for physical mapping and sequencing in various genome projects. The lack of a general method to modify these large bacterial clones, however, has limited their utility in functional studies. We developed a simple method to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0997-859
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  • 6
    Electronic Resource
    Electronic Resource
    Expression pattern of the bullous pemphigoid-180 antigen in normal and neoplastic epithelia (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: BP180 is a 180kDa hemidesmosomal protein recognized by bullous pemphigoid (BP) and pemphigoid gestationis (PG) autoantibodies. Recent cloning and sequence analysis performed by our laboratory have revealed that BP180 is a transmembrane protein with a long extracellular collagen-like region. A rabbit polyclonal antibody has been generated against a recombinant protein, designated GST-NΔ1. containing a segment of the BP180 ectodomain. The resulting antiserum. RNΔ1 A, was shown to specifically react with BP180 on immunoblot, and labelled the extracellular region of the epidermal hemidesmosome on immunoelectron microscopy. A panel of normal and neoplastic human tissues were analysed by indirect immunofluorescence (IF) and RNΔ1A, to determine the distribution of BP180. A total of nine basal cell carcinomas (BCCs) and four squamous cell carcinomas (SCCs) of the skin were also studied. Intense IF staining was seen along the basement membrane zone (BMZ) of the epidermis, hair follicles, and the periphery of sebaceous gland lobules. The sebaceous lobules showed more intense staining in areas close to the duct, The epithelial BMZ of the following tissues also reacted with RNΔ1A: cornea, ocular conjunctiva, buccal mucosa. upper oesophagus, placenta (amnion placentum). umbilical cord and transitional epithelium of the bladder, The epithelium of the jejunum and ovary tailed to react with RNΔ1A, Staining of the BCCs and SCCs was variable. Five of six nodular BCCs showed some anti-BP180 staining at the tumour-stromal interface, although the level of staining was less intense than that observed in the overlying normal epidermis. All three morphoeic BCCs analysed in this investigation did not show any staining with RNΔ1A. Three of four SCCs showed weak staining at the tumour-stromal interface. Thus, the tissue distribution of BP180 paralleled that of hemidesmosomes, and expression of this protein was found to be decreased or absent in cutaneous neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02665.x
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  • 7
    Electronic Resource
    Electronic Resource
    Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 388 (1997), S. 769-773 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Lurcher (Lc) is a spontaneous, semidominant mouse neurological mutation. Heterozygous Lurcher mice (Lc/+) display ataxia as a result of a selective, cell-autonomous and apoptotic death of cerebellar Purkinje cells during postnatal development. Homozygous Lurcher mice (Lc/Lc) die shortly ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/388769a0
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  • 8
    Electronic Resource
    Electronic Resource
    The first australopithecine 2,500 kilometres west of the Rift Valley (Chad) (1995)
    [s.l.] : Nature Publishing Group
    Nature 378 (1995), S. 273-275 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the Chad basin, Pliocene sediments are generally covered by Quaternary ones and are known mostly from boreholes. However, they are exposed around Koro Toro, albeit rather poorly. Two sets of sediments are normally recognized, a lower sandy level lying in disconformity on terrestrial deposits ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/378273a0
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  • 9
    Electronic Resource
    Electronic Resource
    Unusually strong intramolecular magnetic coupling in a chromium hydride cluster (1995)
    [s.l.] : Nature Publishing Group
    Nature 378 (1995), S. 359-362 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Exposure of chromium(ii) hydride [Cp4Cr4(ji3-H)4] (where Cp" is rj5-tetramethyl-ethyl-cyclopentadienyl)15 to hydrogen gas at high pressure (60 atm, C5H12 solvent, 25 á°C, 5 days) yielded a new compound, tentatively identified as the polyhydride [Cp4Cr4Hw], in 65% isolated yield. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/378359a0
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  • 10
    Electronic Resource
    Electronic Resource
    Sorption Isotherms of Aromatic Compounds in Organophilic Polymer Membranes Used in Pervaporation (1999)
    Springer
    Journal of solution chemistry 28 (1999), S. 1159-1174 
    Details
    ISSN: 1572-8927
    Keywords: Sorption isotherms ; aromatic compounds ; polyether-polyamide block-copolymer (PEBA) ; sorption enthalpy ; pervaporation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The sorption isotherms of seven aromatic compounds and some mixtures of them in soft-segment elastomeric polyether-polyamide block-copolymer (PEBA) have been measured at 25 and 50°C using UV-VIS spectroscopic and gas chromatographic analysis. The solubility in PEBA depends significantly on the molecular size of the aromatic compound. Sorption coefficients have been determined. The temperature dependence of the sorption coefficient has been used to determine also the sorption enthalpy of the aromatic compounds from the aqueous solution to the polymer phase. Ternary mixtures consisting of two aromatics in dilute aqueous solution have been investigated in order to study possible synergistic solubility effects. The sorption coefficients can be used for the prediction of the permeation rate across the nonporous PEBA membrane in the so-called pervaporation process. An example is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021755709161
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