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  • 1995-1999  (2)
  • 1945-1949
  • 5  (1)
  • AbbreviationsBIC bicuculline methiodide  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Folic acid for the prevention of congenital anomalies (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 445-450 
    Details
    ISSN: 1432-1076
    Keywords: Key words Folic acid ; Neural tube defects ; Birth defects ; 5 ; 10 Methylenetetrahydrofolate reductase ; Primary prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Paediatricians need to be aware of the broad implications that sufficient maternal folic acid intake has on the wellbeing of the embryo and fetus. There is now strong evidence that adequate periconceptional maternal folic acid supplementation during critical periods of organ formation is associated with reduction in both the occurrence and recurrence of neural tube defects, congenital heart defects (particularly conotruncal heart defects), obstructive urinary tract anomalies, limb deficiencies, orofacial clefts and congenital hypertrophic pyloric stenosis. Inadequate maternal folic acid intake is associated with preterm deliveries, intra-uterine growth retardation, placental abruption and infarction, while maternal folic acid supplementation is associated with a reduction in preterm deliveries and intra-uterine growth retardation. Recently adequate folic acid intake in adults has been associated with a reduction in adult cardiovascular disease and some cancers. A common mutation in the 5,10 methylenetetrahydrofolate reductase gene has been identified which produces a thermolabile variant of 5,10 methylenetetrahydrofolate reductase with reduced enzyme activity. The common mutation is a risk factor both for neural tube defects and adult cardiovascular diseases. Folic acid acts to increase the activity of the variant methylenetetrahydrofolate reductase thereby reducing plasma homocysteine levels. However the polymorphism does not explain all of the protective effects of folic acid. Conclusion Primary prevention of birth defects by adequate periconceptional folic acid supplementation is a major public health opportunity and has wide implications in reducing both mortality and morbidity due to birth defects and several adult diseases. It follows that there would also be a curbing of health care costs related to those disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050850
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    GABAergic inhibition shapes frequency tuning and modifies response properties in the auditory midbrain of the leopard frog (1999)
    Springer
    Journal of comparative physiology 185 (1999), S. 479-491 
    Details
    ISSN: 1432-1351
    Keywords: Key words Iontophoresis ; Inferior colliculus ; Amphibian ; Rana pipiens ; Bicuculline ; GABA ; AbbreviationsBIC bicuculline methiodide ; CF characteristic frequency ; DNLL dorsal nucleus of the lateral lemniscus ; eFTC excitatory frequency tuning curve ; GABAγ-amino butyric acid ; IC inferior colliculus ; iFTC inhibitory frequency tuning curve ; PB phasic burst ; PL-1 primary-like 1 ; PL-2 primary-like 2 ; PL-3 primary-like 3 ; PSTH post-stimulus time histogram ; SPL sound pressure level ; SRN superficial reticular nucleus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The functional role of GABAergic inhibition in shaping the frequency tuning of 96 neurons in the torus semicircularis of the leopard frog, Rana pipiens, was studied using microiontophoresis of the GABAA receptor antagonist, bicuculline methiodide. Bicuculline application abolished, or reduced in size, the inhibitory tuning curves of 72 neurons. In each case, there was a concommitant broadening of the excitatory tuning curve such that frequency-intensity combinations that were inhibitory under control conditions, became excitatory during disinhibition with bicuculline methiodide. These effects were observed irrespective of the excitatory tuning curve configuration prior to bicuculline methiodide application. Results indicate an important role for GABA-mediated inhibition in shaping the frequency selectivity of neurons in the torus semicircularis of the leopard frog. Bicuculline application also affected several other response properties of neurons in the leopard frog torus. Disinhibition with bicuculline methiodide increased both the spontaneous firing rate (18 cells) and stimulus-evoked discharge rate (81 cells) of torus neurons, decreased the minimum excitatory threshold for 18 cells, and altered the temporal discharge pattern of 47 neurons. Additional roles for GABAergic inhibition in monaural signal analysis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003590050409
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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