ISSN:
0947-3440
Schlagwort(e):
Hydroxy lactone, 5-membered, (lactol) tautomer
;
4-Oxocarboxylic acids
;
Keto-cyclol tautomerism
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
(2-Oxocyclohexyl)acetic acid 10 was converted into bicyclic alkoxy γ-lactones 12a-d via intermediate chloro lactone 11 and alkanolysis. Similarly, lactones 15a, b and 18 were prepared. In contrast, simple ring-chain tautomerism directly afforded the title heterocycle 28, a crystalline, stable and well-defined compound. The angular methyl group seems essential for the spontaneous lactonization. 5,5-Dialkoxy-4-oxocarboxylic acids 26a, b without an angular methyl group did not cyclize to bicyclic hydroxy γ-lactones.
Zusätzliches Material:
2 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/jlac.1995199505117
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