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Digitale Medien

Effect of pH and glutathione on lipid peroxidation in tocopherol-enriched liposomes (1995)

Dmitriev, L. F. ; Ivanova, M. V. ; Lebedev, A. V.

Springer

Bulletin of experimental biology and medicine 120 (1995), S. 908-910

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Details

ISSN: 1573-8221

Schlagwort(e): liver microsomes ; tocopherol ; glutathione

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract Tocopherol-enriched liver microsomes are more resistant to lipid peroxidation at an alkaline pH of 8.5 in comparison with microsomes incubated at pH 7.5. An alkaline pH provides conditions for two-electron oxidation of tocopherol, which causes the lipid molecule to revert to the initial state (O2/H exchange). A possible mechanism of inhibition of lipid peroxidation within the physiological range of pH with participation of a glutathione-dependent enzyme is discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02445013

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