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  • 1995-1999  (2)
  • 1920-1924
  • Complex lipid matrices  (1)
  • Gliome  (1)
  • 1
    ISSN: 1431-4630
    Keywords: Key words Radiation-induced hydrocarbons ; Irradiated components ; Processed food ; Complex lipid matrices ; Argentation chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  Detection of irradiated components in processed food with complex lipid matrices can be affected by two problems. First, the processed food may contain only a small amount of the irradiated component, and the radiation-induced hydrocarbons may be diluted throughout the lipid matrix of the whole food. Second, in complex lipid matrices, the detection of prior irradiation is often disturbed by fat-associated compounds. In these cases, common solid phase extraction (SPE) Florisil clean-up alone is inadequate in the detection of prior irradiation. Subsequent SPE argentation chromatography of the Florisil eluate allows the measurement of small amounts of irradiated lipid-containing ingredients in processed food as well as the detection of prior irradiation in complex lipid matrices such as paprika and chilli. SPE argentation chromatography is the first method available for the selective enrichment of radiation-specific hydrocarbons from even complex lipid matrices, thus enabling the detection of irradiation doses as low as 0.025 kGy. Furthermore, by using radiation-induced hydrocarbons in the detection of prior irradiation of paprika and chilli powder, a second independent method, the first being measurement of thermoluminescence, is available for the analysis of these matrices. Such analysis could be achieved by using this highly sensitive, cheap and easy to perform combined SPE Florisil/argentation chromatography method, without the need for sophisticated techniques like SFE-GC/MS or LC-GC/MS, so that highly sensitive detection of prior irradiation could be performed in almost every laboratory.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Kontrastmittel ; Hochdosis ; Metastasen ; Gliome ; MRT ; Key words Contrast agents ; High-dose study ; Cerebral metastases ; Glioma ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In analogy with high-dose contrast-enhanced CT, there have been a few studies during recent years that have dealt with high-dose paramagnetic contrast dyes in MRI. One reason for these studies was the development of new and low-osmolar contrast agents in the MR field. Depending on the clinical problem, a high-dose contrast study in MRI is rarely indicated: (1) in metastatic disease, MR imaging with high-dose contrast material is indicated when the standard dose study is negative or only shows a solitary cerebral lesion or a number of lesions just suitable for radiosurgery; (2) in patients with malignant glioma the high-dose study allows better definition of the tumor margins. If a radical surgical approach is planned, the diagnostic potential should be fully used; if only a biopsy or subtotal debulking is planned, a standard dose study is enough. (3) in patients with MS, a high-dose study is only recommended within therapeutic trials in which the number of active plaques is a primary variable.
    Notes: Zusammenfassung In Analogie zu Erfahrungen mit der Hochdosiskontrastverstärkung in der CT wurden in den letzten Jahren Untersuchungen zur höheren Dosierung der paramagnetischen Kontrastmittel in der MRT gemacht. Dabei spielte auch auf dem MR-Sektor die Entwicklung von niedrig osmolaren Kontrastmitteln eine Rolle. In Abhängigkeit von der konkreten Fragestellung ist die Hochdosis-KM Gabe im kranialen MRT derzeit nur selten indiziert: 1. Zeigt das MR nach der KM-Standarddosis nur eine singuläre intrazerebrale Metastase oder aber eine Anzahl von Metastasen, bei der die Radiochirurgie gerade noch indiziert ist, ist eine zweite MR-Untersuchung mit einer Gesamtdosis von 0,3 mmol/kg KG zu empfehlen. Dies gilt auch, wenn unter der Standarddosis keine zerebrale Metastase bei malignem Grundleiden sichtbar ist. 2. Bei malignen hirneigenen Tumoren ermöglicht die Hochdosis-KM-Gabe eine bessere Definition der Tumorgrenzen. Wenn eine radikale Operation möglich erscheint, sollten die diagnostischen Möglichkeiten voll ausgeschöpft werden. Ist nur eine Biopsie oder eine subtotale Operation geplant, ist die Standarddosis ausreichend. 3. Bei der multiplen Sklerose ist die Hochdosis KM-Gabe nur in Therapiestudien indiziert, wenn eine der Zielvariablen die Anzahl der aktiven Plaques ist.
    Type of Medium: Electronic Resource
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