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  • 1995-1999  (7)
  • 1915-1919
  • 1890-1899
  • Analytical Chemistry and Spectroscopy  (3)
  • Capillary electrophoresis  (3)
  • Cholecystokinin  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Electrophysiological studies of the cholecystokininA receptor antagonists SR27897B and PD140548 in the rat isolated nodose ganglion (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 693-697 
    Details
    ISSN: 1432-1912
    Keywords: Rat nodose ganglion ; Cholecystokinin ; Depolarisation ; Receptor subtypes ; Receptor antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With increased interest in the pharmacology of cholecystokininA (CCKA) receptors, including their trophic and mitogenic effects, the actions of two new non-peptide CCKA receptor antagonists, PD140548 and SR 2789713, were investigated in a convenient model system, the rat isolated nodose ganglion. CCK (1 nM-1 μM) caused concentration-dependent depolarisations when superfused over the nodose ganglion at 37° C as measured by a silicone grease gap technique, and both CCKA antagonists caused significant rightward shifts in the concentration response curve to CCK. SR 2789713 (3 and 10 nM) caused 7.9-and 17.9-fold shifts in the CCK concentration-response curve and the apparent — log KB values for each concentration of antagonist were calculated to be 9.36 and 9.23. Further experiments with PD140548 (30 and 100 nM) yielded shifts of 2.9- and 12.5-fold from which — log KB values were determined to be 7.80 and 8.06. Overall SR 2789713 was significantly more efficacious than PD140548. Thus, the isolated nodose ganglion preparation allows a functional assessment of CCKA-mediated responses, with the results indicating that both SR 27897B and PD 140548 are efficacious CCKA receptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167190
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Electrophysiological studies of the cholecystokininA receptor antagonists SR 27897B and PD140548 in the rat isolated nodose ganglion (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 693-697 
    Details
    ISSN: 1432-1912
    Keywords: Key words Rat nodose ganglion ; Cholecystokinin ; Depolarisation ; Receptor subtypes ; Receptor antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  With increased interest in the pharmacology of cholecystokininA (CCKA) receptors, including their trophic and mitogenic effects, the actions of two new non-peptide CCKA receptor antagonists, PD140548 and SR 27897B, were investigated in a convenient model system, the rat isolated nodose ganglion. CCK (1 nM–1 μM) caused concentration-dependent depolarisations when superfused over the nodose ganglion at 37° C as measured by a silicone grease gap technique, and both CCKA antagonists caused significant rightward shifts in the concentration response curve to CCK. SR 27897B (3 and 10 nM) caused 7.9- and 17.9-fold shifts in the CCK concentration-response curve and the apparent −log KB values for each concentration of antagonist were calculated to be 9.36 and 9.23. Further experiments with PD140548 (30 and 100 nM) yielded shifts of 2.9- and 12.5-fold from which −log KB values were determined to be 7.80 and 8.06. Overall SR 27897B was significantly more efficacious than PD140548. Thus, the isolated nodose ganglion preparation allows a functional assessment of CCKA-mediated responses, with the results indicating that both SR 27897B and PD140548 are efficacious CCKA receptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167190
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Tris (2,2′-bipyridyl)ruthenium (III) as a chemiluminescent reagent for detection in capillary electrophresis (1997)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 20 (1997), S. 643-646 
    Details
    ISSN: 0935-6304
    Keywords: Capillary electrophoresis ; Electogenerated chemiluminescence ; Ru(bpy)32+ ; Tripropylamine ; Proline ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A post- column chemiluminescent technique for thedetection of compounds that are poor chromoshores using electorogenerated chemiluminescence following separation by capillartgy electrophoresis is described. The luminrescent signal is generated followintg the reaction of anlyres (e.g. amines) with Ru(bpy)33+, which isx electrochemically generated post-columan from Ru(bpy)32+. Tripropylamine and proline are used as two model compounds to demostrate the feasibility of the method. Detection limits for the prototype system were in the micromolar rage, suggesting that this technnique offers an alternative to indirect detection of compounds that are poor chromophores with an added selectivity advangage. The system includes the use of a conductive joint to isolate the separation field from the potential necessary to drive the elctrogenerated chemiluminescent reactiion. Addition of the chemiluminescent reagent Ru(bpy)32+ post-column did not decrease the efficiency of the separation. The design and favrication of the novel cell is discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240201205
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Variation in PED response at a gold microelectrode as a function of waveform parameters when applied to alditols and carbohydrates separated by capillary electrophoresis (1995)
    Weinheim : Wiley-Blackwell
    Electroanalysis 7 (1995), S. 1015-1019 
    Details
    ISSN: 1040-0397
    Keywords: Capillary electrophoresis ; Pulsed electrochemical detection ; Alditols ; Carbohydrates ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Results are presented from a systematic study of the noise (N) and peak-to-noise ratio (P/N) obtained for pulsed electrochemical detection (PED) at a gold micro-wire electrode applied to a mixture of alditols and monosaccharides separated by capillary electrophoresis (CE). The electrode potentials and time periods for oxidative cleaning and reductive reactivation of the electrode were held constant in the PED waveform at minimum allowable values and the time period for digital integration of electrode current (tint) was varied from 50 to 800 ms by 50-ms intervals. The value of N was virtually independent of tint and P/N increased approximately as a linear function of tint in the range 50-200 ms corresponding to waveform frequencies in the range 4.5-2.7 Hz. A detection limit of 9 fmol glucose was determined for a 4-nL injection using tint = 200 ms.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140071104
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Rapid analysis of environmental samples using solid-phase microextraction (SPME) and narrow bore capillary columns (1995)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 18 (1995), S. 495-499 
    Details
    ISSN: 0935-6304
    Keywords: SPME ; Capillary columns ; Volatile organic compounds ; Purge and trap ; Chlorinated pesticides ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The application of SPME, a solventless extraction procedure, is demonstrated for two environmental applications. Extraction of VOCs by SPME is coupled with analysis on short narrow bore capillary gas chromatography columns. The technique is shown both as a fast screening tool and as part of an analytical procedure when combined with a mass spectrometer. Data show the linear range of the procedure. The extraction of chlorinated pesticides from hazardous wastewater and drinking water by SPME is also described in this paper. SPME is compared to traditional extraction procedures with respect to cost, time, ease of use, solvent usage, and sample usage.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240180807
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Investigation of substituted dihydronaphthalenes using 1H and 13C NMR spectroscopy (1995)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 33 (1995), S. 592-595 
    Details
    ISSN: 0749-1581
    Keywords: 1H NMR ; 13C NMR ; substituted dihydronaphthalenes ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1H and 13C NMR studies were carried out on the substituted dihydronaphthalene compounds 1,2-dihydro-8-isopropyl-6,7-dimethoxy-2-methylnaphthalene, 3-bromo-1, 2-dihydro-8-isopropyl-6, 7-dimethoxy-2-methylnaphthalene, 3, 4-dihydro-5-isopropyl-6, 7-dimethoxy-3-methyl-1(2H)-naphthalenone, 1, 2-dihydro-6, 7-dimethoxy-2, 8-dimethylnaphthalene, 3-bromo-1, 2-dihydro-6, 7-dimethoxy-2, 8-dimethylnaphthalene and 3, 4-dihydro-6, 7-dimethoxy-3, 5-dimethyl-1(2H)-naphthalenone. Complete assignments of the proton and carbon spectra were made using one- and two-dimensional NMR techniques including APT, COSY, NOESY and 1H-13C HETCOR spectroscopy.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260330717
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Viscous effects in capillary electrophoresis: Theory and experiment (1995)
    Weinheim : Wiley-Blackwell
    Electrophoresis 16 (1995), S. 2074-2085 
    Details
    ISSN: 0173-0835
    Keywords: Capillary electrophoresis ; Polymeric additive ; Chemical binding ; Polyethylene glycol ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Simple theory which relates the viscous effects of additives used in capillary electrophoresis (CE) to resolution and resolution per unit time are developed for small molecule separations in the absence of sieving effects. The resolution theory shows that there is no advantage to using viscous additives for resolution improvement unless either a binding energy difference exists between the solutes and additive, or viscous effects cause a reduction in the vector sum of electrophoretic and electroosmotic velocities when these are of opposite sign. In general, increasing the viscosity is shown to result in a loss of resolution per unit time. Theory demonstrates that in cases where only binding is considered to be present, the maximum resolution increase is found to be at relatively small amounts of additive. In addition, specific regions of the electrophoreogram may demonstrate resolution enhancement at a specific concentration while other regions exhibit a resolution decrease, as compared to no additive present. CE separations of the components in a Triton surfactant, conducted using a polyethylene glycol (PEG) additive, demonstrate that improved resolution for some of the peaks exists at a specific PEG concentration. These results are mostly explained through the reduction in electroosmotic flow velocity that takes place through additive adsorption to the capillary wall, although some binding is present.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.11501601337
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    Paper (German National Licenses)
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