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  • 1995-1999  (8)
  • 1915-1919
  • 1890-1899
  • Analytical Chemistry and Spectroscopy  (3)
  • Physical Chemistry  (3)
  • Cholecystokinin  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Electrophysiological studies of the cholecystokininA receptor antagonists SR27897B and PD140548 in the rat isolated nodose ganglion (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 693-697 
    Details
    ISSN: 1432-1912
    Keywords: Rat nodose ganglion ; Cholecystokinin ; Depolarisation ; Receptor subtypes ; Receptor antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With increased interest in the pharmacology of cholecystokininA (CCKA) receptors, including their trophic and mitogenic effects, the actions of two new non-peptide CCKA receptor antagonists, PD140548 and SR 2789713, were investigated in a convenient model system, the rat isolated nodose ganglion. CCK (1 nM-1 μM) caused concentration-dependent depolarisations when superfused over the nodose ganglion at 37° C as measured by a silicone grease gap technique, and both CCKA antagonists caused significant rightward shifts in the concentration response curve to CCK. SR 2789713 (3 and 10 nM) caused 7.9-and 17.9-fold shifts in the CCK concentration-response curve and the apparent — log KB values for each concentration of antagonist were calculated to be 9.36 and 9.23. Further experiments with PD140548 (30 and 100 nM) yielded shifts of 2.9- and 12.5-fold from which — log KB values were determined to be 7.80 and 8.06. Overall SR 2789713 was significantly more efficacious than PD140548. Thus, the isolated nodose ganglion preparation allows a functional assessment of CCKA-mediated responses, with the results indicating that both SR 27897B and PD 140548 are efficacious CCKA receptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167190
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Electrophysiological studies of the cholecystokininA receptor antagonists SR 27897B and PD140548 in the rat isolated nodose ganglion (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 693-697 
    Details
    ISSN: 1432-1912
    Keywords: Key words Rat nodose ganglion ; Cholecystokinin ; Depolarisation ; Receptor subtypes ; Receptor antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  With increased interest in the pharmacology of cholecystokininA (CCKA) receptors, including their trophic and mitogenic effects, the actions of two new non-peptide CCKA receptor antagonists, PD140548 and SR 27897B, were investigated in a convenient model system, the rat isolated nodose ganglion. CCK (1 nM–1 μM) caused concentration-dependent depolarisations when superfused over the nodose ganglion at 37° C as measured by a silicone grease gap technique, and both CCKA antagonists caused significant rightward shifts in the concentration response curve to CCK. SR 27897B (3 and 10 nM) caused 7.9- and 17.9-fold shifts in the CCK concentration-response curve and the apparent −log KB values for each concentration of antagonist were calculated to be 9.36 and 9.23. Further experiments with PD140548 (30 and 100 nM) yielded shifts of 2.9- and 12.5-fold from which −log KB values were determined to be 7.80 and 8.06. Overall SR 27897B was significantly more efficacious than PD140548. Thus, the isolated nodose ganglion preparation allows a functional assessment of CCKA-mediated responses, with the results indicating that both SR 27897B and PD140548 are efficacious CCKA receptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167190
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tris (2,2′-bipyridyl)ruthenium (III) as a chemiluminescent reagent for detection in capillary electrophresis (1997)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 20 (1997), S. 643-646 
    Details
    ISSN: 0935-6304
    Keywords: Capillary electrophoresis ; Electogenerated chemiluminescence ; Ru(bpy)32+ ; Tripropylamine ; Proline ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A post- column chemiluminescent technique for thedetection of compounds that are poor chromoshores using electorogenerated chemiluminescence following separation by capillartgy electrophoresis is described. The luminrescent signal is generated followintg the reaction of anlyres (e.g. amines) with Ru(bpy)33+, which isx electrochemically generated post-columan from Ru(bpy)32+. Tripropylamine and proline are used as two model compounds to demostrate the feasibility of the method. Detection limits for the prototype system were in the micromolar rage, suggesting that this technnique offers an alternative to indirect detection of compounds that are poor chromophores with an added selectivity advangage. The system includes the use of a conductive joint to isolate the separation field from the potential necessary to drive the elctrogenerated chemiluminescent reactiion. Addition of the chemiluminescent reagent Ru(bpy)32+ post-column did not decrease the efficiency of the separation. The design and favrication of the novel cell is discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240201205
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Rapid analysis of environmental samples using solid-phase microextraction (SPME) and narrow bore capillary columns (1995)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 18 (1995), S. 495-499 
    Details
    ISSN: 0935-6304
    Keywords: SPME ; Capillary columns ; Volatile organic compounds ; Purge and trap ; Chlorinated pesticides ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The application of SPME, a solventless extraction procedure, is demonstrated for two environmental applications. Extraction of VOCs by SPME is coupled with analysis on short narrow bore capillary gas chromatography columns. The technique is shown both as a fast screening tool and as part of an analytical procedure when combined with a mass spectrometer. Data show the linear range of the procedure. The extraction of chlorinated pesticides from hazardous wastewater and drinking water by SPME is also described in this paper. SPME is compared to traditional extraction procedures with respect to cost, time, ease of use, solvent usage, and sample usage.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240180807
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Investigation of substituted dihydronaphthalenes using 1H and 13C NMR spectroscopy (1995)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 33 (1995), S. 592-595 
    Details
    ISSN: 0749-1581
    Keywords: 1H NMR ; 13C NMR ; substituted dihydronaphthalenes ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1H and 13C NMR studies were carried out on the substituted dihydronaphthalene compounds 1,2-dihydro-8-isopropyl-6,7-dimethoxy-2-methylnaphthalene, 3-bromo-1, 2-dihydro-8-isopropyl-6, 7-dimethoxy-2-methylnaphthalene, 3, 4-dihydro-5-isopropyl-6, 7-dimethoxy-3-methyl-1(2H)-naphthalenone, 1, 2-dihydro-6, 7-dimethoxy-2, 8-dimethylnaphthalene, 3-bromo-1, 2-dihydro-6, 7-dimethoxy-2, 8-dimethylnaphthalene and 3, 4-dihydro-6, 7-dimethoxy-3, 5-dimethyl-1(2H)-naphthalenone. Complete assignments of the proton and carbon spectra were made using one- and two-dimensional NMR techniques including APT, COSY, NOESY and 1H-13C HETCOR spectroscopy.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260330717
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  • 6
    Electronic Resource
    Electronic Resource
    Rate constants for some reactions of free radicals with haloacetates in aqueous solution (1995)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 27 (1995), S. 605-612 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The kinetics of the acqueous-phase reactions of the free radicals ·OH, ·Cl2-, and SO4-· with the halogenated acetates, CH2FCOO-, CHF2COO-, CF3COO-, and with CH2ClCOO-, CHCl2COO-, CCl3COO- were investigated. Generally, the reactivity decreases with increasing halogen substitution and is in the order k(·OH) 〉 k(SO4-·) 〉 k(·Cl2-), but there is no general relation between the effect on reactivity of chlorine and fluorine substitution. © 1995 John Wiley & Sons, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550270610
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    On the application of an oxygen probe in chemical kinetics: The influence of the probe response on kinetic measurement (1995)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 27 (1995), S. 829-842 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Membrance covered oxygen probes are frequently used to monitor the progress of chemical reactions involving dissolved oxygen. For reactions that are comparable in rate to the response of the oxygen probe it is difficult to obtain the correct kinetic constants directly from the probe signal with traditional kinetic data manipulation methods. In this article, we apply the method of impulse response function to describe the probe signal of an oxygen probe for three different types of simple chemical reactions. The impulse response function is obtained experimentally. Using the impulse response function we have obtained the relationships between the probe signal and the kinetic parameters of these reactions. The slow response of the probe has two effects on the kinetic curves of the reaction studied: a time-lag and distortion of the shape of the kinetic curve throughout the reaction. The latter effect becomes significant when the reaction is fast. Procedures to obtain the correct kinetic information from the oxygen probe signal are described. © 1995 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550270809
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  • 8
    Electronic Resource
    Electronic Resource
    Kinetics of the reaction of the sulfate radical with the oxalate anion (1996)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 28 (1996), S. 195-199 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The kinetics of the reaction of the sulfate radical, SO4-, with the oxalate anion C2O42- was studied in aqueous solution and second-order rate constants, corrected for the effects of ionic strength, derived. Measurements were carried out over the temperature range 24-60°C resulting in the expression k0 = 2.10 ± 0.96 × 108 exp(-1080 ± 140/T) L mol-1 s-1. © 1996 John Wiley & Sons, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.5
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