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  • 1995-1999  (4)
  • 1870-1879
  • Deiodination  (2)
  • Psychotherapie  (2)
  • 1
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Borderline-Persönlichkeitsstörung ; Psychotherapie ; Linehan ; Key words Borderline ; Personality ; Disorder ; Psychotherapy ; Linehan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary M. Linehan developed “dialectical behavioral therapy” specifically to treat chronically suicidal borderline patients. It rests on a biosocial model that assumes a disorder in the regulation of emotions and in tolerance of stress. The numerous dysfunctional patterns of behavior such as self-destructive behavior, inability to govern impulses or severe dissociative phenomena are regarded as attempts at problem-solving. This concept of therapy focuses on the continuing balance between the necessity of accepting maladaptive behavior patterns in both an intrapsychic and an interactional context while still working to change them. A comprehensive manual outlines the clearly structured therapy and integrates a wide choice of therapeutic strategies. Parallel to development of the therapy itself, a method also was developed for testing therapist adherence to the manual's guidelines, thus providing a basis for empirical evaluation. An initial controlled, randomized study demonstrated the significant superiority of this method to methods of unspecific psychotherapy at various levels. In the current endeavor to develop disorder-specific approaches to the treatment of personality disorders, “dialectical behavioral therapy” is a noteworthy model.
    Notes: Zusammenfassung Die Dialektisch-Behaviorale Psychotherapie wurde von M. Linehan spezifisch für die Behandlung chronisch suizidaler Borderline-Patienten entwickelt. Sie basiert auf einem biosozialen Modell, das eine Störung der Emotionsregulation und der Spannungstoleranz zugrunde legt. Die umfangreichen dysfunktionalen Verhaltensmuster, wie selbstschädigendes Verhalten, Impulskontrollverluste oder schwere dissoziative Phänomene, werden als erlernte Problembewältigungsversuche gesehen. Im Mittelpunkt des therapeutischen Konzeptes steht die fortwährende Balance zwischen der Notwendigkeit, die Sinnhaftigkeit maladaptiver Verhaltensmuster im intrapsychischen und interaktionellen Kontext zu akzeptieren und dennoch an deren Veränderung zu arbeiten. Ein umfangreiches Manual ordnet die klaren Strukturen der Therapie und integriert ein breites Spektrum therapeutischer Strategien. Parallel mit der Therapie wurde eine Methode entwickelt, die Orientierung des Therapeuten an den manualisierten Richtlinien zu überprüfen. Somit ist diese Therapie einer empirischen Überprüfung zugänglich. Eine erste kontrollierte, randomisierte Studie zeigte eine signifikante Überlegenheit dieser Methode gegenüber unspezifischen Psychotherapien auf mehreren Ebenen. Im gegenwärtigen Bemühen um die Entwicklung störungsspezifischer Ansätze in der Behandlung von Persönlichkeitsstörungen könnte die Dialektisch-Behaviorale Psychotherapie als modellhaft bezeichnet werden.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 22 (1996), S. 575-581 
    ISSN: 1432-1238
    Keywords: Low T3 syndrome ; Selenium ; Deiodination ; Glutathione peroxidase ; Balance study ; Critically ill ; Trauma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective Thyroxine (T4) is deiodinated to triiodothyronine (T3) by the hepatic type I iodothyronine deiodinase, a selenoprotein that is sensitive to selenium (Se) deficiency. After severe injury, T4 deiodination is decreased, leading to the low T3 syndrome. Injury increases free radical production, which inactivates the iodothyronine deiodinase. The aims were to study the Se status after major trauma and to investigate its relation to the low T3 syndrome. Design Preliminary prospective descriptive study. Setting Intensive care unit at a university teaching hospital. Patients and methods 11 patients aged 41±4 years (mean±SEM), with severe multiple injuries (Injury Severity Score 29±2 points). A balance study was performed from day 1 to day 7. Serum and urine samples were collected from the time of admission until day 7, then on days 10, 15, 20, 25 and 30. Nonparametric tests and Pearson's correlation coefficients were used for analysis. Results Cumulated Se losses were 0.88±0.1 μmol/24h. Serum Se was decreased from admission to day 7. T3, free T3, and the T3/T4 ratio were low until day 5, being lowest on day 2; T4 and thyroid stimulating hormone were normal. Serum Se was correlated with T3 (r=0.55,p=0.0001), and with free T3 (r=0.35). Conclusion Se status is altered after trauma, with decreased Se serum levels upon admission to the ICU but with no major Se losses. Se is probably redistributed to the tissues. The correlation between Se and T3, along with the parallel decrease in T4 deiodination, indicates that reduced deiodination might be related to the transient decrease in serum Se.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 22 (1996), S. 575-581 
    ISSN: 1432-1238
    Keywords: Key words Low T3 syndrome ; Selenium ; Deiodination ; Glutathione peroxidase ; Balance study ; Critically ill ; Trauma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Thyroxine (T4) is deiodinated to triiodothyronine (T3) by the hepatic type I iodothyronine deiodinase, a selenoprotein that is sensitive to selenium (Se) deficiency. After severe injury, T4 deiodination is decreased, leading to the low T3 syndrome. Injury increases free radical production, which inactivates the iodothyronine deiodinase. The aims were to study the Se status after major trauma and to investigate its relation to the low T3 syndrome. Design: Preliminary prospective descriptive study. Setting: Intensive care unit at a university teaching hospital. Patients and methods: 11 patients aged 41±4 years (mean±SEM), with severe multiple injuries (Injury Severity Score 29±2 points). A balance study was performed from day 1 to day 7. Serum and urine samples were collected from the time of admission until day 7, then on days 10, 15, 20, 25 and 30. Non-parametric tests and Pearson‘s correlation coefficients were used for analysis. Results: Cumulated Se losses were 0.88±0.1 μmol/24 h. Serum Se was decreased from admission to day 7. T3, free T3, and the T3/T4 ratio were low until day 5, being lowest on day 2; T4 and thyroid stimulating hormone were normal. Serum Se was correlated with T3 (r=0.55, p=0.0001), and with free T3 (r=0.35). Conclusion: Se status is altered after trauma, with decreased Se serum levels upon admission to the ICU but with no major Se losses. Se is probably redistributed to the tissues. The correlation between Se and T3, along with the parallel decrease in T4 deiodination, indicates that reduced deiodination might be related to the transient decrease in serum Se.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Reproduktionsmedizin 15 (1999), S. 285-293 
    ISSN: 1434-808X
    Keywords: Schlüsselwörter Erektile Dysfunktion ; psychogene Erektionsstörungen ; Sexualtherapie ; Psychotherapie ; Psychosomatik ; Kombination psychotherapeutischer und medikamentöser Verfahren ; Key words Erectile dysfunction ; Psychogenic causes ; Sex therapy ; Psychotherapy ; Psychosomatics ; Combination therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In the light of highly successful somatic therapies psychotherapeutic interventions in erectile dysfunction are nowadays less considered. But they are nevertheless highly effective and needed according to the psycho-somatic nature of the condition. In this article we present an etiologic framework of psychogenic erectile dysfunction as well as the diagnostic approach and therapeutic interventions. Finally we discuss the need for an increased research in the combination of psychotherapeutic and medical therapy.
    Notes: Zusammenfassung Angesichts großer Erfolge in der medikamentösen Behandlung der erektilen Dysfunktion haben psychotherapeutische Interventionen in letzter Zeit wenig Aufmerksamkeit erhalten. Doch ist bei Erektionsstörungen als psycho-physisches Gesamtgeschehen auch die Kenntnis psychologischer Faktoren für eine erfolgreiche Behandlung nötig. Die vorliegende Arbeit stellt grundlegende ätiologische Konzepte psychogener Erektionsstörungen vor, erläutert die psychologische Diagnostik und die gängigen Modelle für Sexualberatung und Sexualtherapie. Schließlich wird die Möglichkeit einer Kombination von medikamentöser und psychotherapeutischer Behandlung diskutiert.
    Type of Medium: Electronic Resource
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