ISSN:
1432-2307
Keywords:
Ferric nitrilotriacetate
;
Renal proximal tubules
;
γ-glutamyltranspeptidase
;
Renal cysts
;
Renal tumours
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In experiments using ferric nitrilotriacetate (Fe-NTA) as a renal carcinogen, multiple renal cysts are often observed in addition to renal tumours. In the present study, we used 3-week-old male ddY mice and examined the relation between renal cysts and cancer development. Four months after the start of Fe-NTA administration, we observed cysts in the renal cortex in all Fe-NTA-treated mice, but not in Fe-free NTA-treated mice. Three types of cysts were observed, but only those which originated from the renal proximal tubules showed multi-layered or papillary growth of cyst epithelial cells. Using histochemical staining, we found a cyst formation-tumour induction sequence, and the supposed cystic-papillary tumour induced by Fe-NTA was of proximal tubular cell origin. We also found that the minimum dose of Fe-NTA capable of inducing renal tumours in ddY mice was 10 mg of iron/kg/day, four times in 2 weeks.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00203743
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