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  • 1995-1999  (4)
  • curved surface  (2)
  • Acute lymphocytic leukemia  (1)
  • Clonal abnormalities  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Hematology and cell therapy 38 (1997), S. 291-296 
    ISSN: 1279-8509
    Keywords: Fanconi anemia ; Chromosomal abnormalities ; Clonal abnormalities ; Leukemias ; Myelodysplastic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fanconi anemia (FA) belongs to the chromosomal instability syndromes and frequently evolves toward hematopoietic malignancy. While the recent isolation of one of the genes of FA allows to view to gene therapy, the best treatment is currently bone marrow transplantation. In this review, the data on clonal chromosome abnormalities of FA patients are presented and their significance discussed in the context of the disease.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1279-8509
    Keywords: Acute lymphocytic leukemia ; B-cell acute leukemia ; Translocation (genetics)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The t(9;11)(p21–22;q23) translocation is frequently associated with acute monoblastic leukemia but may occasionally be seen in patients with acute lymphoblastic leukemia (ALL). We report a case of childhood ALL associated with t(9;11)(p21–22;q23) as the unique recurring chromosomal abnormality. A 3-month-old girl presented with “lymphomatous” ALL (renal enlargement), a high leukocyte count and central nervous system (CNS) involvement. Leukemic cell typing revealed a sIg+ B-cell immunophenotype without CD10 and CD34 antigenic expression while the blast cell morphology was of the FAB-L1 type. Splitting of a YAC encompassing the MLL gene was shown by fluorescence in situ hybridization (FISH) studies of the patient’s metaphase chromosomes. Rearrangement of the MLL gene was confirmed by Southern blot analysis. Despite treatment with an hyperintensive polychemotherapeutic regimen, the patient achieved a complete remission but relapsed 9 months later. These results provide further evidence that the t(9;11) may be observed in ALL, involves the MLL gene and is associated with a poor outcome. Moreover, this observation clearly illustrates that sIg+ B-cell ALL is not necessarily associated with a Burkitt (L3) morphology.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 28 (1998), S. 201-213 
    ISSN: 0271-2091
    Keywords: curved surface ; shallow water ; non-hydrostatic ; spillway ; finite element ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In Part I a detailed derivation of a more general shallow water equation set was developed via a perturbation analysis. A finite element computational model of these more general equations is now constructed and the model behavior is compared with conventional shallow water formulations applied to an outletworks flume. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 28 (1998), S. 191-200 
    ISSN: 0271-2091
    Keywords: curved surface ; shallow water ; non-hydrostatic ; spillway ; finite element ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The standard two-dimensional shallow water equation formulation assumes a mild bed slope and no curvature effect. These assumptions limit the applicability of these equations for some important classes of problems. In particular, flow over a spillway is affected by the bed curvature via a decidedly non-hydrostatic pressure distribution. A detailed derivation of a more general equation set is given here in Part I. The method relies upon a perturbation expansion to simplify a bed-fitted co-ordinate configuration of the three-dimensional Euler equations. The resulting equations are essentially the equivalent of the two-dimensional shallow water equations but with curvature included and without the mild slope assumption. A finite element analysis and flume result are given in Part II. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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