ISSN:
1573-2568
Keywords:
HEPATITIS C
;
SOLUBLE ADHESION MOLECULES
;
CYTOKINES
;
INFLAMMATION
;
FIBROSIS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Lymphocyte adhesion to endothelium,extravasation, and adhesion to hepatocytes are mediatedby adhesion molecules and constitute important steps inthe liver inflammation due to chronic hepatitis C(HCV-CH). We measured soluble intercellular adhesionmolecule (sICAM-1, sCD54), vascular cell adhesionmolecule (sVCAM-1, sCD106), E-selectin (sCD62E), as wellas interleukin (IL)-1β, IL-8, and tumor necrosis factor-α (TNF-α) concentrations inthe serum of 22 patients with HCV-CH in comparison to 20seronegative healthy volunteers. sICAM-1, sVCAM-1,sCD62E, TNF-α, and IL-8 but not IL-1βconcentrations were significantly elevated in patients.sICAM-1 and sCD62E correlated with TNF-α andaspartate amino transferases levels. sICAM-1 correlatedwith liver lobular inflammation whereas sVCAM-1, sCD62E, and IL-8 correlated with liver fibrosis.Measurement of soluble adhesion molecules may be an easyway to follow liver inflammation and fibrosis duringHCV-CH.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018818801824
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