ISSN:
1432-069X
Keywords:
Key words Collagen
;
Azelastine
;
Skin fibroblast
;
Scleroderma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of azelastine hydrochloride on cell proliferation and collagen synthesis in cultured human skin fibroblasts were studied. Azelastine inhibited cell proliferation during proliferating cell phases. Azelastine was found to inhibit collagen synthesis without altering cell proliferation during quiescent phases. It did not alter the ratio of type I to III collagen synthesis. Northern blot analysis of collagen chain mRNAs revealed that the levels of α 1 (I), α 1 (III) and α 1 (VI) mRNAs were reduced by azelastine treatment, whereas the level of α 2 (VI), α 3 (VI) mRNAs were not significantly changed. These results suggest that azelastine modulates collagen synthesis at a pretranslational level. Azelastine inhibited collagen synthesis in fibroblasts from scleroderma patients to the same extent as in normal skin fibroblasts. This drug may be useful in the treatment of fibrotic diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004030050106
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