ISSN:
1437-7799
Keywords:
Key words: Hemodialysis
;
Survival analysis
;
Cerebrovascular disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background. The overall survival rate and contributory factors were examined in patients undergoing hemodialysis in one dialysis program. The clinical profiles of dialysis patients who suffered from cerebro- and cardiovascular diseases (CCVD) were also studied. Methods. Data were available for 1064 patients who had received hemodialysis treatment for more than 3 months in our program (17 centers) in Miyazaki, Japan, between 1971 and 1994. Results. The respective 3-, 5-, and 10-year actuarial survival rates were 85%, 79%, and 66%. The Cox proportional hazard model identified three variables: age at start of hemodialysis (adjusted relative hazard [RH], 1.05), sex (RH, 1.42 for males), and type of underlying renal disease (RH, 1.00 for chronic glomerulonephritis, 2.80 for diabetes mellitus, 1.59 for nephrosclerosis), as being significantly associated with survival. Patients with CCVD had a high incidence of cerebral hemorrhage (8.7 per 1000 person-years). Patients whose first CCVD episode occurred within 36 months of starting hemodialysis were older, and more frequently had diabetes mellitus or nephrosclerosis and suffered from cerebral infarction. Long-term hemodialysis patients with CCVD more frequently had chronic glomerulonephritis as the underlying disease and had a higher incidence of cerebral hemorrhage. Conclusion. Age, sex, and underlying renal disease were independent factors that contributed to the mortality of the hemodialysis patients. There was a high incidence of CCVD among the hemodialysis patients, but the etiology of CCVD may differ depending on the underlying renal disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s101570050051
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