ISSN:
1612-1112
Keywords:
Supercritical fluid chromatography
;
Molecular mechanics
;
Chiral stationary phase
;
Matrix interaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A model is devised using molecular mechanics to simulate chromatographic separations of enantiomers. Theoretical results derived from this model are compared with experimental findings obtained using supercritical fluid chromatography. The model is then developed to incorporate the effects of binding the stationary phase to a matrix. Computed results show that addition of the matrix into the model has significant effects on the ability of the stationary phase to separate racemic mixtures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02267948
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