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  • 1
    Electronic Resource
    Electronic Resource
    Potentiation of stimulus-induced phosphoinositide breakdown by calmodulin antagonists in C6 glioma cells (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 679-684 
    Details
    ISSN: 1432-1912
    Keywords: Key words Calmodulin antagonistsr ; Phosphoinositide turnover ; Phospholipase C ; C6-glioma cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  To investigate the role of calmodulin (CaM)-dependent pathways in agonist-induced phosphoinositide (PI) turnover, the influence of several CaM antagonists on PI-phospholipase C (PLC) activation in intact and permeabilized C6 glioma cells was examined. The extent of PI turnover was assessed by measuring the accumulation of inositol phosphates (IPs) in the presence of LiCl in C6 glioma cells prelabelled with myo-[3H]inositol. Trifluoperazine, N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7), fendiline and calmidazolium themselves had no effect on basal IP formation, but concentration-dependently (1–30 μM) potentiated ATP-, NaF- and A23187-stimulated IP formation. The maximal response to ATP (1 mM) was increased by up to 50%, while the concentration for half-maximal effect (EC50, 60 μM) was unaffected by trifluoperazine. In digitonin-permeabilized C6 glioma cells, the concentration-dependent increase of PI-PLC activation elicited by free Ca2+ was potentiated by the GTP analogue, guanosine 5′-[γ-thio]triphosphate (GTPγS), with an EC50 of 6 μM. Trifluoperazine (1–30 μM) enhanced the Ca2+-stimulated IP formation concentration dependently and this potentiation was counteracted by the addition of CaM. In the combined presence of each CaM antagonist studied and GTPγS, an additive increase in IP formation was observed. The results indicate that CaM antagonists enhance stimulus-induced IP formation in C6 glioma cells primarily by increasing the Ca2+-dependent activation of PI-PLC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171328
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Second law analysis on fractal-like fin under crossflow (1995)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 41 (1995), S. 2314-2317 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690411015
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Boiling on a straight pin fin (1996)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 42 (1996), S. 2721-2728 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: In this study, Multimode boiling on a straight pin is theoretically investigated. Axial steady-state temperature distributions along the fin are numerically evaluated, as well as their linear stability characteristics. When film and transition boiling coexist on the fin surface, or only the transition boiling covers the entire fin, the operation remains stable only if the fin length is less than some critical value. When transition and nucleate boiling coexist on a fin, or the fin is in the three-mode boiling (film + transition + nucleate boiling), the entry of nucleate boiling at the fin tip stabilizes the boiling process. This study on base heat flow and fin efficiency with the stability criteria also suggests a new fin design methodology.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690421004
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison technetium of Tc-99m disofenin cholescintigraphy with ultrasonography in the differentiation of biliary atresia from other forms of neonatal jaundice (1996)
    Springer
    Pediatric surgery international 12 (1996), S. 30-33 
    Details
    ISSN: 1437-9813
    Keywords: Key words Technetium Tc-99m disofenin ; cholescintigraphy ; Biliary atresia ; Ultrasonography ; Neonatal hepatitis ; Neonatal jaundice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Technetium Tc-99m disofenin cholescintigraphy (CS) and ultrasonography (US) are two major clinical methods used in differentiating biliary atresia (BA) from neonatal jaundice. To compare the diagnostic utility of these two modalities, 66 patients with neonatal cholestasis (15 BA, 3 choledochal cyst (CC), 32 neonatal hepatitis, 13 prolonged jaundice, 2 total parenteral nutrition, and 1 sepsis) underwent Tc-99m disofenin CS and US. The diagnostic sensitivity, specificity, and accuracy of CS in differentiating BA from other forms of neonatal jaundice was 100%, 87.5%, and 90.5%, respectively, and for US 86.7%, 77.1%, and 79.4%, respectively. Tc-99m disofenin CS after premedication with phenobarbital and cholestyramine is a convenient and reliable method of differentiating BA from neonatal hepatitis, with a diagnostic accuracy superior to that of US. However, US is the initial imaging procedure of choice in patients presenting with jaundice to rule out anatomic anomalies such as CC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01194798
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison technetium of Tc-99m disofenin cholescintigraphy with ultrasonography in the differentiation of biliary atresia from other forms of neonatal jaundice (1996)
    Springer
    Pediatric surgery international 12 (1996), S. 30-33 
    Details
    ISSN: 1437-9813
    Keywords: Technetium Tc-99m disofenin cholescintigraphy ; Biliary atresia ; Ultrasonography Neonatal hepatitis ; Neonatal jaundice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Technetium Tc-99m disofenin cholescintigraphy (CS) and ultrasonography (US) are two major clinical methods used in differentiating biliary atresia (BA) from neonatal jaundice. To compare the diagnostic utility of these two modalities, 66 patients with neonatal cholestasis (15 BA, 3 choledochal cyst (CC), 32 neonatal hepatitis, 13 prolonged jaundice, 2 total parenteral nutrition, and 1 sepsis) underwent Tc-99m disofenin CS and US. The diagnostic sensitivity, specificity, and accuracy of CS in differentiating BA from other forms of neonatal jaundice was 100%, 87.5%, and 90.5%, respectively, and for US 86.7%, 77.1%, and 79.4%, respectively. Tc-99m disofenin CS after premedication with phenobarbital and cholestyramine is a convenient and reliable method of differentiating BA from neonatal hepatitis, with a diagnostic accuracy superior to that of US. However, US is the initial imaging procedure of choice in patients presenting with jaundice to rule out anatomic anomalies such as CC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01194798
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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