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  • 1995-1999  (3)
  • CPT-11  (2)
  • Colon (rat)  (2)
  • Key words Mast cells  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Eicosanoid-mediated Cl− secretion induced by the antitumor drug, irinotecan (CPT-11), in the rat colon (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 351 (1995), S. 309-314 
    Details
    ISSN: 1432-1912
    Keywords: Antitumor therapy ; Cl− secretion ; Colon (rat) ; CPT-11 ; Diarrhoea ; Irinotecan Thromboxane A2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Irinotecan (CPT-11) is active against a broad range of human cancer. One of the side-effects of irinotecan is a strong diarrhoea. In order to investigate the mechanism underlying this diarrhoea, the effect of irinotecan on anion secretion across the isolated rat distal colon was studied. Irinotecan caused a concentration-dependent increase in short-circuit current (Isc). The increase in Isc was completely dependent on the presence of Cl− ions and was supressed by furosemide and the Cl− channel blocker NPPB (5-nitro-2-(3-phenylpropylamino)-benzoate), indicating that it is caused by a Cl− secretion. The secretory response was inhibited by indomethacin, 1-benzylimidazole, a thromboxane synthase inhibitor, and SK&F 88046 ((N,N′bis-[7-(3-Chlorobenzeneaminosulfonyl)-1,2,3,4-tetrahydroisoquinolyl)disulfonylimide), a thromboxane A2 receptor blocker. In isolated crypts irinotecan had no effect on the membrane potential. Consequently, the secretion induced by irinotecan is an indirect one, caused by the stimulation of eicosanoid production, e.g. thromboxane A2, in the subepithelial tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233252
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Glucocorticoids inhibit proliferation and adhesion of the IL-3-dependent mast cell line, MC/9, to NIH/3T3 fibroblasts, with an accompanying decrease in IL-3 receptor expression (1999)
    Springer
    Archives of dermatological research 291 (1999), S. 224-231 
    Details
    ISSN: 1432-069X
    Keywords: Key words Mast cells ; c-kit ; Glucocorticoids ; IL-3 ; receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effects of glucocorticoids on IL-3-dependent proliferation and c-kit expression of cells of the mouse mast cell line, MC/9. Glucocorticoids (dexamethasone, prednisolone, and hydrocortisone) inhibited IL-3-dependent MC/9 cell proliferation, whereas sex steroids (progesterone, β-estradiol, and testosterone) had no effect. Flow cytometric analysis revealed that glucocorticoids reduced the expression of the IL-3 receptor on MC/9 cells. Immunoblot and Northern blot analyses indicated that glucocorticoids also reduced the expression of both c-kit protein and c-kit mRNA transcript. Furthermore, the adhesion of MC/9 cells to stem cell factor-expressing NIH/3T3 cells was reduced following glucocorticoid treatment. Our results indicate that glucocorticoids inhibit IL-3-dependent MC/9 mast cell proliferation, with an accompanying decrease in IL-3 receptor expression. Glucocorticoids also reduced c-kit expression on MC/9 cells resulting in a decreased adhesion to NIH/3T3 fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050398
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Eicosanoid-mediated Cl-secretion induced by the antitumor drug, irinotecan (CPT-11), in the rat colon (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 351 (1995), S. 309-314 
    Details
    ISSN: 1432-1912
    Keywords: Key words Antitumor therapy ; Cl- secretion ; Colon (rat) ; CPT-11 ; Diarrhoea ; Irinotecan ; Thromboxane A2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Irinotecan (CPT-11) is active against a broad range of human cancer. One of the side-effects of irinotecan is a strong diarrhoea. In order to investigate the mechanism underlying this diarrhoea, the effect of irinotecan on anion secretion across the isolated rat distal colon was studied. Irinotecan caused a concentration-dependent increase in short-circuit current (Isc). The increase in Isc was completely dependent on the presence of Cl- ions and was supressed by furosemide and the Cl- channel blocker NPPB (5-nitro-2-(3-phenylpropylamino)-benzoate), indicating that it is caused by a Cl- secretion. The secretory response was inhibited by indomethacin, 1-benzylimidazole, a thromb- oxane synthase inhibitor, and SK&F 88046 ((N,N′-bis[7-(3-Chlorobenzeneaminosulfonyl)-1,2,3,4-tetrahydroisoquinolyl)disulfonylimide), a thromboxane A2 receptor blocker. In isolated crypts irinotecan had no effect on the membrane potential. Consequently, the secretion induced by irinotecan is an indirect one, caused by the stimulation of eicosanoid production, e.g. thromboxane A2, in the subepithelial tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233252
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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