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  • 1
    Electronic Resource
    Electronic Resource
    TGFβ-1 regulation of VEGF production by breast cancer cells (1997)
    Springer
    Annals of surgical oncology 4 (1997), S. 621-627 
    Details
    ISSN: 1534-4681
    Keywords: Vascular endothelial growth factor ; Transforming growth factor β-1 ; Breast cancer ; Angiogenesis ; Metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Angiogenesis is essential for tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is the most potent angiogenic factor identified to date. TGFβ-1 acts as an indirect angiogenic agent. Methods: VEGF and TGFβ-1 were measured in the serum of breast cancer patients and agematched controls and in tumor tissue of cancer patients by ELISA. VEGF protein and mRNA expression by breast tumor cell lines were examined, and the effect of TGFβ-1 on VEGF production in these cells was assessed. Results: VEGF levels were significantly higher (P=.03) in the serum of patients with breast cancer compared to age-matched controls. A positive correlation was found between serum (r=0.539) and tumor tissue (r=0.688) levels of VEGF and TGFβ-1. Metastatic MDA-MB-231 breast cancer cells produce more VEGF than do the primary BT474 cells. TGFβ-1 significantly (P〈.05) increased production of VEGF. Conclusions: Breast cancer cells constitutively produce VEGF protein and mRNA. There is a relationship between VEGF and TGFβ-1 levels in breast cancer patients, and TGFβ-1 regulates VEGF expression by breast cancer cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02303745
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Carcinoid disease (1997)
    Springer
    Diseases of the colon & rectum 40 (1997), S. 349-362 
    Details
    ISSN: 1530-0358
    Keywords: Carcinoid ; Neuroendocrine tumors ; 5-Hydroxyindole acetic acid ; Octreotide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Carcinoid syndrome is the product of a rare but fascinating malignant neoplasm. Carcinoid syndrome was described more than 100 years ago, and recent advances in diagnostic localization, elucidation of the mechanisms of oncogenesis, treatment options, and, consequently, patient prognosis have been made. Current modalities of treatment, possible therapeutic implications of new avenues of research, and current literature on the chemotherapeutic combinations used are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02050428
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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