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  • 1
    Electronic Resource
    Electronic Resource
    Multi-chemothermoimmunotherapy for human colon adenocarcinoma in vitro (1995)
    Springer
    Cancer chemotherapy and pharmacology 37 (1995), S. 235-241 
    Details
    ISSN: 1432-0843
    Keywords: Chemotherapy ; TNF ; Hyperthermia ; Colon Adenocarcinoma ; Multimodality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effective adjunctive therapies for colorectal carcinoma are clearly needed. We evaluated the cytotoxic responses in vitro of human colon carcinoma cell lines to combined modalities: 5-fluorouracil/leucovorin (5-FU/LV), carboplatin (CP), tumor necrosis factor (TNF) and hyperthermia (HTX). Cytotoxicity was evaluated in a cell proliferation assay using crystal violet staining. 5-FU/LV was administered 2–3 days before TNF and CP, followed 1 h later by HTX. These cell lines were relatively resistant to HTX alone (42°C for 2 h), but were heterogeneous in their responses to various doses of the other single agents. This heterogeneity was also evident for combined modalities: the geneity was also evident for combined modalities: the HCT-15 cell line exhibited significant supra-additivity for selected doses of CP, TNF and 5-FU/LV, which was further enhanced by hyperthermia. In contrast, the HT-29 cell line did not demonstrate a strong pattern for supra-additivity, whereas the DLD-1 cell line had an intermediate response. Thus, our results suggest one approach to develop effective and dose-sparing multimodality therapeutic regimens for colon adenocarcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688322
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  • 2
    Electronic Resource
    Electronic Resource
    Stability of acrylic latices in a semibatch reactor (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 60 (1996), S. 1301-1311 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The effects of various reaction variables on the stability of acrylic latices in a semibatch reactor were investigated by measuring the amount of coagulum formed and particle volume changes caused by limited flocculation. The amount of coagulum could be reduced signif-icantly with an increase in the level of sodium lauryl sulfate (SLS) in the monomer emulsion feed. An increase in the amount of SLS in the initial reactor charge resulted in an increase in the particle volume change due to limited flocculation later in the process. The larger the ratio of methyl methacrylate (MMA) to butyl acrylate (BA) in the copolymer, the greater the amount of coagulum produced. Both coagulum and particle volume change increased with an increase in the electrolyte concentration. Within the range studied (500-800 rpm), the agitation speed was not important to the coagulation process. Experimental data also indicated that the polymer particles could lose their stability rapidly above 40% total solids content because of the crowding effect. © 1996 John Wiley & Sons, Inc.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 3
    Electronic Resource
    Electronic Resource
    Semibatch emulsion copolymerization of methyl methacrylate and butyl acrylate (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 55 (1995), S. 571-581 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The concentration of sodium lauryl sulfate (SLS) in the initial reactor charge is the most important parameter in determining the particle size of a semibatch emulsion copolymerization of methyl methacrylate (MMA) and butyl acrylate (BA). The number of particles formed is proportional to the concentration of SLS to the 0.5-1.2 power and it is proportional to the concentration of the nonyl phenol-40 mol ethylene oxide adduct to the 0.014-0.72 power. The number of particles is almost independent of the concentration of the initiator. The solubility of monomer in water has an important effect on the nucleation mechanism according to the literature. However, the ratio of MMA to BA does not show any significant effect on the latex particle size in our laboratory. The particle size also increases with increasing ionic strength or agitation speed. Experimental data of particle-size distribution and molecular weight distribution support the coagulative nucleation mechanism when the concentration of SLS is way below its critical micelle concentration (CMC). © 1995 John Wiley & Sons, Inc.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070550404
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    Paper (German National Licenses)
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