ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Ultrastructural changes and immunohistochemical localization of advanced glycation end products in the heart of streptozotocin-treated Mongolian gerbils (1999)

Fujii, T. ; Nishigaki, Ryutaro ; Kawahara, Kiyoko ; [et al.]

Springer

Medical electron microscopy 32 (1999), S. 43-49

add to mindlist on the mindlist

Details

ISSN: 1437-773X

Keywords: Key words Advanced glycation end products (AGEs) ; Mongolian gerbil ; Coronary artery ; Cardiomyopathy ; Streptozotocin (STZ)

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract This study was designed to clarify the developing mechanism of cardiomyopathy and vasculopathy in streptozotocin-treated Mongolian gerbils. Twenty male Mongolian gerbils (MG; 10–12 weeks old) were used, and 150 mg/kg of streptozotocin (STZ) was injected into the left femoral vein. Six control male MG were injected intravenously with normal saline. The animals showed severe hyperglycemia (up to 330 ± 96.4 mg/dl) by 1 week after streptozotocin administration. At 1 week after STZ treatment, cardiomyocytes revealed no significant change, but unclear striated structures were demonstrated in cardiomyocytes at 4 weeks. After 1 year, anisocytosis was observed, and in the perinuclear region granular components were stained positively with periodic acid-Schiff reagent. Ultrastructurally, at 4 weeks and 1 year after STZ treatment, cardiomyocytes were irregular in size, and oval amorphous and lysosomal electron-dense bodies were observed in perinuclear and cytoplasmic regions. In coronary arteries, endothelial and medial cells revealed increased vesicles and intercellular collagen fibrils. Capillaries showed slight swelling of endothelial cells associated with the lamellar thickening of basement membrane and collagen fibrils in the perivascular regions. Immunohistochemically, advanced glycation end products (AGE) were observed in the cytoplasm of vascular and heart cells, and ultrastructurally the reaction products were demonstrated in the endoplasmic reticulum and lysosomes of cardiomyocytes and vascular cells in the STZ-treated Mongolian gerbils. AGE may play an important role not only in angiopathy but also in cardiomyopathy of STZ-treated Mongolian gerbils after STZ treatment.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s007950050007

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Compatibility and tensile behavior of polypropylene/ethylene-propylene rubber blends (1995)

Nomura, T. ; Nishio, T. ; Fujii, T. ; [et al.]

Stamford, Conn. [u.a.] : Wiley-Blackwell

Polymer Engineering and Science 35 (1995), S. 1261-1271

add to mindlist on the mindlist

Details

ISSN: 0032-3888

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: This study clarifies and quantifies factors which increase the ductility of a low-molecular-weight propylene homopolymer having an intrinsic viscosity of 0.89 dl/g. The tensile behavior of homopolymer/ethylene-propylene rubber (EPR) blends was studied from the viewpoint of the associated molecular structure of EPR and its compatibility with the homopolymer. When EPR is “dissolved” in a homopolymer, the glass transition temperature (Tg) of the amorphous phase of a homopolymer was found to shift to a lower temperature, with homopolymer/EPR compatibility being subsequently evaluated using this shift, i.e., Δtg. Results show two conditions are required to improve the ductility of the low-molecular weight propylene homopolymer: ΔTg must be ≥ 3°C and ≥ 30 wt% EPR must be blended with the homopolymer.

Additional Material: 18 Ill.