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  • 1995-1999  (3)
  • Chemistry  (2)
  • Etonitazene  (1)
  • General Chemistry
  • Nuclear reaction
  • Organic Chemistry
  • 1
    ISSN: 1432-2072
    Keywords: Key wordsEthanol ; Etonitazene ; Deiodinases ; Thyroid hormones ; Rat brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of acute, low-dose administration of ethanol (1 g/kg bodyweight) and the μ-opioid receptor agonist etonitazene (30 μg/kg bodyweight) on the activities of the iodothyronine deiodinase isoenzymes were investigated in nine regions of the rat brain. The experiments were performed at three different times of the 24-h cycle (1300, 2100 and 0500 hours) and the rats were decapitated 30 and 120 min after administration of the respective drugs. Interest was focused on changes in the two enzymes that catalyze 1) 5′-deiodination of thyroxine (T4) to the biologically active triiodothyronine (T3), i.e. type II 5′-deiodinase (5′D-II) and 2) 5 (or inner-ring) deiodination of T3 to the biologically inactive 3′3-T2, i.e. type III deiodinase (5D-III). 120 min after administration of ethanol and etonitazene 5D-III activity was selectively inhibited in the frontal cortex (at 1300 and 1700 hours) and the amygdala (at all three measuring times). The 5′D-II activity was significantly enhanced 30 min after administration of etonitazene in the frontal cortex, amygdala and limbic forebrain, and after administration of ethanol in the amygdala alone. These effects on 5′D-II activity were seen at 2100 hours only. In conclusion, the two different addictive drugs both reduced the inactivation of the physiologically active thyroid hormone T3 and enhanced its production. These effects occurred almost exclusively in the brain regions which were most likely to be involved in the rewarding properties of addictive drugs. As thyroid hormones have stimulating and mood-elevating properties, an involvement of these hormones in the reinforcing effects of addictive drugs seems conceivable.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 27 (1996), S. 287-296 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: The mechanical properties of polycristalline materials are depent on the type, the combination and the orientation of the elements in the micro structure. By means of the method of Visioplasticity assumptions are currently realized to analyse kinematic parameters inside of single grains and grain groups. Strength of the free surface of the specimen will be rough by its plastical deformation, it was difficult to register the increments of deformation of the grid. By further development of a method of picture analysis it is also possible to reproduce a 3d-surface by utilization of single light microscopical pictures.
    Notes: Die mechanischen Eigenschaften polykristalliner Werkstoffe sind von der Art der Mikrostrukturelemente, deren Zusammenwirken und Orientierung hauptsächlich abhängig. Mittels der Methode der Visioplastizität werden gegenwärtig Voraussetzungen geschaffen, die die Analyse kinematischer Feldkenngrößen innerhalb einzelner Strukturelemente (Kristallite) und Strukturverbände gestattet. Aufgrund der verformungsbedingten Aufrauhung der freien Probenoberfläche traten Probleme bei der Aufnahme der Rasterverformungen auf. Über die Weiterentwicklung eines Verfahrens der Bildverarbeitung wurde es möglich, 3D-Oberflächenstrukturen anhand der Auswertung lichtmikroskopischer Einzelbildaufnahmen abzubilden.
    Additional Material: 25 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 70 (1998), S. 560-566 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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