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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Arthroskopie 11 (1998), S. 287-290 
    ISSN: 1434-3924
    Keywords: Schlüsselwörter Mensikoid ; Sprunggelenk ; Arthroskopie ; Key words Meniscoid ; Ankle ; Arthroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The meniscoid lesion, which was first described by Wolin in 1950 as a mass of hyalinized tissue following an inversion sprain of the ankle, is a frequent but fairly unknown cause of persistent pain in the anterior part of the upper ankle in sports traumatology. The aim of the present study is to describe the typical history, diagnostic measures, and operative treatment of this syndrome. This lesion was found in 19 of 58 arthroscopies of the ankle joint in athletes. In 17 patients, the earlier ankle sprain had been treated conservatively, and in two patients operatively. The ankle arthroscopy was performed an average of 22 months after the original trauma. A meniscoid lesion was found in four tennis players, four runners, three badminton, three squash, and three soccer players, and two basketball players. After an average follow-up period of 12 months postarthroscopy, 12 patients were examined. All 19 patients complained about anterior ankle pain and swelling. Only one of the patients showed lateral instability. Intraoperatively, all meniscoid lesions were associated with synovitis. Of the 12 athletes examined in the follow-up period, ten returned to full sports activity. Seven patients did not complain of any swelling, four only on rare occasions, and one persistently. No pain was reported in eight cases, minor pain in three cases, and persistent, permanent pain in one case, probably caused by advanced chondromalacia. Anterior ankle pain induced by meniscoid impingement is a very good indication for arthroscopic surgery. After resection of the meniscoid lesion, a fast return to full sports activity can be expected if the meniscoid syndrome is not accompanied by serious simultaneous lesions. In the case of a meniscoid lesion, arthroscopy should be performed at short notice, because in patients with longer-lasting lesions worse results are found frequently at follow-up.
    Notes: Nach wiederholten Supinationstraumen des OSG kommt es in vielen Fällen zu persistierenden vorderen Gelenkschmerzen. Diese werden oft durch eine meniskoide Läsion verursacht. Sie wurde bereits 1950 von Wolin als Ansammlung hyalinen Gewebes beschrieben, das nach Umknicktraumen des oberen Sprunggelenks zu Einklemmungen zwischen Talus und Fibula führen kann. Ziel der vorliegenden Studie ist es, das zu selten diagnostizierte Meniskoidsyndrom in seiner Anamnese, Diagnostik und Therapie darzustellen. Arthroskopische und histologische Befunde werden beschrieben sowie kurz- und mittelfristige Ergebnisse der arthroskopischen Therapie aufgezeigt. Bei 58 Arthroskopien des OSG von Sportlern wurde die Diagnose 19mal gestellt. 17mal war die dem Meniskoidsyndrom vorangehende Sprunggelenkdistorsion konservativ, 2mal operativ behandelt worden. Die Arthroskopie des OSG erfolgte durchschnittlich 22 Monate nach dem ursprünglichen Trauma (Spannbreite 6 Monate bis 5,1 Jahre). Betroffen waren 4 Tennisspieler, je 3 Badminton- und Squashspieler, 4 Jogger, 3 Fußballer und 2 Basketballspieler. 12 Personen konnten durchschnittlich 12 Monate nach der Arthroskopie des Sprunggelenks nachuntersucht werden. Alle 19 Patienten gaben einen vorderen Gelenkschmerz und rezidivierende Schwellungen, 12 Einklemmungen und 1 Patient eine Instabilität an. Intraoperativ fand sich neben den meniskoiden Strukturen stets eine ausgeprägte Synovitis. Von 12 nachuntersuchten bzw. befragten Patienten trieben 10 wieder Sport auf dem gleichen Niveau wie vor dem Eintritt der Beschwerden. Sieben Patienten berichteten über keine, 4 über gelegentliche und 1 über ständige Schwellneigung. Schmerzfrei waren 8 Patienten, gelegentlich traten 3mal und ständig 1mal Schmerzen auf. Diese mußte auf eine fortgeschrittene Chondromalazie zurückgeführt werden. Der durch ein meniskoides Impingement ausgelöste vordere Gelenkschmerz des OSG ist eine dankbare Indikation für einen arthroskopischen Eingriff. Nach Abtragung der meniskoiden Läsion ist eine rasche Wiederherstellung der Sportfähigkeit zu erwarten, sofern nicht ein begleitender Knorpeldefekt oder andere Schäden vorliegen. Bei Diagnose des Meniskoidsyndroms sollte die Arthroskopie rasch erfolgen, da bei länger bestehenden Läsionen häufiger Begleitschäden zu erwarten sind und schlechtere Nachuntersuchungsergebnisse ermittelt wurden.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 37 (1995), S. 377-382 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The analysis of known protein structures is a very valuable and indispensable tool for deciphering the complex rules relating sequence to structure in proteins. On the other hand, the design of novel proteins is certainly the most severe test of our understanding of such rules. In this report we describe our own attempt to develop appropriate tools for the investigation of known protein structure properties and their applications to the design of a novel, all β protein. The success of the design project is a demonstration of the usefulness of careful analysis of the data base of known protein structures. © 1994 John Wiley & Sons, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 32 (1998), S. 414-424 
    ISSN: 0887-3585
    Keywords: P1 nuclease ; X-ray crystallography ; substrate recognition ; catalytic mechanism ; thiophosphorylated oligonucleotides ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The reaction mechanism of nuclease P1 from Penicillium citrinum has been investigated using single-stranded dithiophosphorylated di-, tetra-, and hexanucleotides as substrate analogs. The complexes crystallize in tetragonal and orthorhombic space groups and have been solved by molecular replacement. The high resolution structures give a clear picture of base recognition by P1 nuclease at its two nucleotide-binding sites, especially the 1.8 Å structure of a P1-tetranucleotide complex which can be considered a P1-product complex. The observed binding modes are in agreement with a catalytic mechanism where the two closely spaced zinc ions activate the attacking water while the third, more exposed zinc ion stabilizes the leaving 03' oxyanion. Stacking as well as hydrogen bonding interactions with the base 5' to the cleaved phosphodiester bond are important elements of substrate binding and recognition. Modelling of a productive P1-substrate complex based on the solved structures suggests steric hindrance as the likely reason for the resistance of Rp-phosphorothioates and phosphorodithioates. Differences with the highly homologous nuclease S1 from Aspargillus oryzae are discussed. Proteins 32:414-424, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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