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  • 1
    Electronic Resource
    Electronic Resource
    Induction of cytokines, chemokines and adhesion molecule mRNA in a rat forebrain reperfusion model (1997)
    Springer
    Acta neuropathologica 93 (1997), S. 154-158 
    Details
    ISSN: 1432-0533
    Keywords: Key words Rat forebrain ; Reperfusion ; Cytokine ; Intercellular adhesion molecule-1 ; Chemokine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cellular damage secondary to reperfusion following ischemic insult has been hypothetically attributed to an inflammatory cascade concerted by cell-to-cell interactions. While the role of several cytokines and adhesion molecules in reperfusion injury of the brain has been explored to a certain extent, their regulatory and temporary profiles remain unclear. We have addressed the temporal features of the induction of mRNA for proinflammatory cytokines, adhesion molecules and chemokines at an acute phase subsequent to reperfusion in rat forebrain. Semiquantitatively calibrated reverse transcription-polymerase chain reaction analysis was employed to assess the relative expression of mRNA for intercellular adhesion molecule (ICAM)-1, interleukin (IL)-1α, IL-1β, IL-2, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, monocyte-chemoattractant protein (MCP)-1, and macrophage migration inhibitory factor (MIF). The increase in mRNA from the basal levels after reperfusion followed one of two different patterns; an increase occurring as early as 1 h, or a slight increase continuing up to 24 h after reperfusion. The former pattern was seen for ICAM-1, IL-1α, IL-1β, TNF-α, and MCP-1, and the latter for IL-6 and MIF. These results were consistent with the proinflammatory properties of the immediately induced cytokines, which may be involved in the initiation step of the inflammatory cascade, causing the secondary cellular responses and finally leading to further brain damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050596
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  • 2
    Electronic Resource
    Electronic Resource
    Surgical Treatment of Pineal Region Tumours Through the Occipital Transtentorial Approach: Evaluation of the Effectiveness of Intra-Operative Micro-Endoscopy Combined with Neuronavigation (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 801-809 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Pineal region tumour; endoscope; navigation; surgery.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Object. To determine the efficacy and accuracy of surgically-assisted systems including endoscopy combined with neuronavigation in the treatment of pineal region tumours through the occipital transtentorial approach, an evaluation of thirty-one patients undergoing surgery was performed over a 10-year period.  Method. The study was performed in 2 parts. The surgical approach to the pineal region was the same in the two parts, but in part 2 a smaller craniotomy window was used. Part 1 (from March 1989 to March 1997) included 15 patients who underwent surgical removal of pineal region tumours without using assisted systems; four out of the fifteen patients had surgery-related complications, including seizure and hemianopsia. Part 2 (from April 1997 to February 1999) included 16 patients who underwent surgical treatment by the same surgical team and with assisted systems; all 16 patients had excellent outcomes, with no complications.  Conclusions. Although this study was the first specifically to examine the efficacy of endoscopy combined with neuronavigation in the treatment of pineal region tumours, our findings suggest that these systems are very useful, safe, and accurate in evaluating the primary tumour and surrounding anatomy as well as in determining operative strategy, such as the location and size of the scalp incision, craniotomy, and the extent of surgical removal. Therefore, we conclude that the addition of endoscopy combined with neuronavigation to standard surgical procedures can improve the outcome of surgical treatment of pineal region tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050380
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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